Transmission of Mycobacterium tuberculosis to recipients of single lung transplants from the same donor.

Academic Article

Abstract

  • Recipients of organ transplants are at increased risk for infection both because of immunosuppression and because of the transfer of microbes through the donor organs. We report two cases of M. tuberculosis disease in recipients of single lung transplants who shared a common donor. Both recipients developed pulmonary tuberculosis, one having fever and pulmonary infiltrates and the other having subclinical disease with M. tuberculosis organisms being recovered from bronchoalveolar lavage. Restriction fragment length polymorphism analysis on both isolates of M. tuberculosis revealed a common source. The donor of both lungs had a normal chest radiograph and no known prior history of M. tuberculosis infection of disease. These cases are the first report of two single lung recipients developing pulmonary tuberculosis from a common donor.
  • Keywords

  • Adult, Bronchoalveolar Lavage Fluid, DNA, Bacterial, Female, Humans, Immunosuppression, Lung Transplantation, Middle Aged, Mycobacterium tuberculosis, Opportunistic Infections, Polymorphism, Restriction Fragment Length, Risk Factors, Tissue Donors, Tuberculosis, Pulmonary
  • Digital Object Identifier (doi)

    Author List

  • Ridgeway AL; Warner GS; Phillips P; Forshag MS; McGiffin DC; Harden JW; Harris RH; Benjamin WH; Zorn GL; Dunlap NE
  • Start Page

  • 1166
  • End Page

  • 1168
  • Volume

  • 153
  • Issue

  • 3