The structure of the Plasmodium falciparum EBA175 ligand domain and the molecular basis of host specificity

Academic Article

Abstract

  • Erythrocyte-binding antigen 175 (EBA175) is one of the best-characterized Plasmodium falciparum merozoite ligands; the recently solved crystal structure of EBA175 reveals that terminal sialic acids on the erythrocyte glycoprotein glycophorin A are a crucial factor for erythrocyte recognition by EBA175 because they lock into pockets on its surface. Comparison with Plasmodium reichenowi EBA175 indicates that these interactions have a pivotal role in the host-specific adaptations of parasite ligands. © 2006 Elsevier Ltd. All rights reserved.
  • Digital Object Identifier (doi)

    Author List

  • Chattopadhyay D; Rayner J; McHenry AM; Adams JH
  • Start Page

  • 143
  • End Page

  • 145
  • Volume

  • 22
  • Issue

  • 4