Osteopontin, a substrate for transglutaminase and Factor XIII activity

Academic Article

Abstract

  • Osteopontin (OPN), an extracellular matrix cell adhesion protein, was found to serve as a substrate for the incorporation of radiolabelled putrescine mediated by a commercial preparation of guinea pig liver transglutaminase. Preliminary evidence also suggests that OPN serves as a substrate for the plasma transglutaminase, Factor XIIIa. While the protein substrates to which OPN is linked in vivo have not been identified, it is reasonable to speculate that this capacity of OPN may dictate its extracellular location and thereby affect its role in bone homeostasis, tumorigenesis, metastasis, resistance to bacterial infections or, perhaps, wound repair. © 1991.
  • Authors

    Digital Object Identifier (doi)

    Author List

  • Prince CW; Dickie D; Krumdieck CL
  • Start Page

  • 1205
  • End Page

  • 1210
  • Volume

  • 177
  • Issue

  • 3