Endocrine and metabolic characteristics of polyoma large T transgenic mice that develop ACTH-producing pituitary tumors

Academic Article

Abstract

  • The authors have analyzed several endocrine and metabolic parameters in polyoma large T transgenic mice (PyLT-1) that develop adrenocorticotropic hormone (ACTH)-immunoreactive pituitary tumors and in nontransgenic mice with tumor transplants. All clinically ill PyLT-1 mice (13 to 16 months of age) had pituitary macroadenomas and elevated plasma ACTH levels. Compared to PyLT-1 transgenic mice, the ACTH plasma concentrations in immunocompetent mice with transplant tumors were markedly raised. In these animals, a secondary effect of hypercorticotropism was documented by a moderate hyperglycemia. Furthermore, mice with transplant tumors had a pathological weight increase from the time the tumor was palpable. The present study supports and extends the authors' previous morphological documentation of the similarity between the ACTH-producing tumors in this mouse model and human Cushing's disease.
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    Digital Object Identifier (doi)

    Author List

  • Helseth A; Haug E; Nesland JM; Siegal GP; Fodstad O; Bautch VL
  • Start Page

  • 879
  • End Page

  • 885
  • Volume

  • 82
  • Issue

  • 5