Mucosal Immunoregulation: Environmental Lipopolysaccharide and GALT T Lymphocytes Regulate the IgA Response

Academic Article

Abstract

  • In this review, we have emphasized: 1) bacterial lipopolysaccharide (LPS) involvement in IgA responses to orally administered thymic-dependent (TD) antigens; 2) characterization of Peye’s patch (PP) lymphoreticular cells; and 3) gastrointestinal immunization with gram negative pathogens and anti-LPS immunity to infection. Gut LPS, which interacts with PP lymphoreticular cells, is a major determinant for host responses to orally administered TD antigens. Bacteroides species are the principal microflora present in the gastrointestinal tract and our studies with phenol-water LPS extracts from Bacteroides fragilis indicate that both polysaccharide and lipid A activate lymphoreticular cells. The B. fragilis lipid A moiety, like that derived from E. coli and Salmonella LPS, induces B cell mitogenic responses in cultures from LPS responsive mice, but does not stimulate C3H/HeJ B cells. The inability of lipid A to stimulate gut-associated lymphoreticular tissue (GALT) cells of C3H/HeJ mice results in the induction of greater T helper cell activity in this tissue in response to orally administered TD antigens and ultimately results in an elevated IgA response pattern. © 1984, The Japanese Society of Clinical Pharmacology and Therapeutics. All rights reserved.
  • Digital Object Identifier (doi)

    Author List

  • McGhee JR; Michalek SM; Kiyono H; Eldridge JH; Colwell DE; Williamson SI; Wannemuehler MJ; Jirillo E; Mosteller LM; Spalding DM
  • Start Page

  • 261
  • End Page

  • 280
  • Volume

  • 28
  • Issue

  • 3