Anti-Hu antibody neuropathy: a clinical, electrophysiological, and pathological study.

Academic Article


  • OBJECTIVE: The objective is to report the clinical, electrophysiological, and histopathological features of 16 patients with anti-Hu antibody neuropathy. METHODS: Clinical and electrophysiological data in 16 patients (11 females and 5 males) with positive anti-Hu antibody and nerve biopsy data in 9 cases were analyzed. RESULTS: Cancer was detected in 11 patients, including 9 with small-cell lung cancer. Classical paraneoplastic subacute sensory neuronopathy (SSN) and/or encephalomyelitis (EM) was observed in 7 patients (44%), including 5 with SSN. The most common clinical feature was sensory-motor neuropathy (SMN), accounting for 50% of cases. Though sensory nerve conduction abnormality was the prominent feature in 14 (88%) cases, sensory and motor nerve conduction was abnormal in all cases. Motor nerve conduction findings were typical of axonal degeneration. The most common nerve conduction pattern was that of SMN, with a sensory neuronopathy pattern being observed in only 3 cases. Sural nerve biopsy in 9 patients showed axonal degeneration in all cases and inflammatory cells in 4 cases. CONCLUSIONS: Classical sensory neuronopathy is rarer than expected, both clinically and electrophysiologically. Motor involvement is not uncommon and motor nerve conduction abnormality is frequently seen. A diverse clinical and electrophysiological, and histopathological spectrum was observed in this neuropathy. SIGNIFICANCE: New guidelines for the selection of patients for anti-Hu antibody test are recommended.
  • Authors


  • Action Potentials, Aged, Antibodies, Anti-Idiotypic, Carcinoma, Small Cell, Demyelinating Diseases, ELAV Proteins, Electric Stimulation, Encephalomyelitis, Female, Humans, Male, Middle Aged, Muscle, Skeletal, Nerve Degeneration, Nerve Tissue Proteins, Neural Conduction, Paraneoplastic Polyneuropathy, RNA-Binding Proteins, Reaction Time, Retrospective Studies
  • Digital Object Identifier (doi)

    Author List

  • Oh SJ; G├╝rtekin Y; Dropcho EJ; King P; Claussen GC
  • Start Page

  • 28
  • End Page

  • 34
  • Volume

  • 116
  • Issue

  • 1