Multifocal motor sensory demyelinating neuropathy: inflammatory demyelinating polyradiculoneuropathy.

Academic Article


  • The authors present two cases that provide the first autopsy findings in multifocal acquired demyelinating sensory and motor neuropathy (MADSAMN). Both cases documented multifocal but asymmetric demyelinating neuropathy with rare axonal degeneration. One case clearly documented an inflammatory polyradiculoplexoneuropathy, confirming the inflammatory nature of this neuropathy. This study showed that MADSAMN is an inflammatory demyelinating polyradiculoneuropathy that shares histologic features observed in chronic inflammatory demyelinating polyradiculoneuropathy and multifocal motor neuropathy (MMN), suggesting a similar immunopathogenesis for these entities.
  • Authors

    Published In

  • Neurology  Journal
  • Keywords

  • Anti-Inflammatory Agents, Autopsy, Disease Progression, Fatal Outcome, Female, Guillain-Barre Syndrome, Humans, Male, Microscopy, Electron, Transmission, Middle Aged, Motor Neurons, Muscle Weakness, Nerve Fibers, Myelinated, Neurons, Afferent, Paralysis, Peripheral Nerves, Polyradiculoneuropathy, Polyradiculoneuropathy, Chronic Inflammatory Demyelinating, Sensation Disorders, Spinal Nerve Roots
  • Digital Object Identifier (doi)

    Pubmed Id

  • 24297818
  • Author List

  • Oh SJ; LaGanke C; Powers R; Wolfe GI; Quinton RA; Burns DK
  • Start Page

  • 1639
  • End Page

  • 1642
  • Volume

  • 65
  • Issue

  • 10