Expression of c-kit and platelet-derived growth factor receptors in ovarian granulosa cell tumors.

Academic Article

Abstract

  • OBJECTIVE: This study aimed at evaluating the expression of tyrosine kinase receptors c-kit, (platelet-derived growth factor receptor-alpha (PDGFR-alpha), and PDGFR-beta in ovarian granulosa cell tumors (GCTs). STUDY DESIGN: Primary ovarian GCT specimens were obtained for immunohistochemical staining.The expressions of c-kit, PDGFR-alpha, and PDGFR-beta were analyzed and scored by a semiquantitative (SQ) method. Normal ovarian tissue from the same patients' specimens served as internal controls. RESULTS: A total of 21 specimens were available for evaluation. C-kit was expressed in only 2 samples, whereas both PDGFR-alpha and PDGFR-beta stained positive in 100% of tumors. PDGFR targets demonstrated strong positive expression in intensity and amount of tissue stained. Normal ovarian tissue demonstrated complete absence of staining for all 3 antibodies evaluated. CONCLUSIONS: The data demonstrated significant expression of PDGFR targets of imatinib mesylate in GCTs, whereas normal ovarian tissues had a complete absence of staining.This expression profile provides the rationale to investigate the role of imatinib mesylate in PDGFR-positive GCTs.
  • Authors

    Keywords

  • Adolescent, Adult, Aged, Benzamides, Child, Drug Delivery Systems, Epithelium, Female, Gene Expression Regulation, Neoplastic, Granulosa Cell Tumor, Humans, Imatinib Mesylate, Middle Aged, Ovarian Neoplasms, Piperazines, Protein-Tyrosine Kinases, Proto-Oncogene Proteins c-kit, Pyrimidines, Receptor, Platelet-Derived Growth Factor alpha, Receptor, Platelet-Derived Growth Factor beta, Stromal Cells, Young Adult
  • Digital Object Identifier (doi)

    Author List

  • Rocconi RP; Matthews KS; Kimball KJ; Conner MG; Baker AC; Barnes MN
  • Start Page

  • 673
  • End Page

  • 677
  • Volume

  • 15
  • Issue

  • 7