Insulin signal transduction: The role of protein phosphorylation

Academic Article


  • Recent evidence suggests that the mechanism of insulin action depends in part on protein phosphorylation on tyrosine residues. A cascade of phosphorylation/dephosphorylation reactions is proposed to modulate multiple enzymes involved in metabolism, protein synthesis, and cell growth. Direct evidence is presented for the phosphorylation of myelin basic protein and microtubule-associated protein 2 on tyrosine residues by the insulin receptor.
  • Authors

    Digital Object Identifier (doi)

    Author List

  • Pillion DJ; Kim SJ; Kim H; Meezan E
  • Start Page

  • 40
  • End Page

  • 52
  • Volume

  • 303
  • Issue

  • 1