Increased sulfate uptake in skin fibroblasts isolated from cystic fibrosis patients

Academic Article

Abstract

  • Sulfate uptake into skin fibroblasts from patients with cystic fibrosis is increased. Sulfate transport studies were carried out in skin fibroblasts isolated from age/sex matched cystic fibrosis and normal subjects. Sulfate transport occurred mainly via a carrier-mediated proton-stimulated SO42/Cl-exchange. The capacity (Vmax) of the uptake system operating at physiological concentrations of sulfate was stimulated in cystic fibrosis, but the affinity of the carrier for sulfate was not altered. © 1988 Academic Press, Inc.
  • Digital Object Identifier (doi)

    Author List

  • Elgavish A; Meezan E
  • Start Page

  • 99
  • End Page

  • 106
  • Volume

  • 152
  • Issue

  • 1