Considerable controversy surrounds the use of hormone replacement therapy (HRT) for treatment of peri-menopausal symptoms. Recent publications from three large, prospective randomized studies call the safety of HRT into question, and leave patients searching for answers. Nutrient therapy may provide symptomatic relief without increasing risk of chronic disease. In this study, results of a series of uncontrolled prospective studies of peri-menopausal symptom relief using Menopace® nutrient therapy were combined to provide a broad perspective on the safety and effectiveness of this alternative treatment modality. Data from seven studies with a total of 766 subjects were analyzed. Subjects with specific menopausal symptoms reported improvement after three months of daily use of the therapy, ranging from 87.8% of subjects with hot flashes to 67.5% of subjects with poor concentration reporting improvement. Overall improvement in menopausal symptoms was reported in 93.2% of all subjects. These results provide consistent evidence of the effective-ness of comprehensive, nutritionally balanced nutrient therapy for treatment of menopausal symptoms. While most evidence-based practitioners focus primarily on research results from randomized, controlled clinical trials, other forms of research evidence can also guide clinicians searching for safe and effective treatment options for their patients. © 2006 Controversies in Obstetrics and Gynecology, Polish Society of Perinatal Medicine, the International Society of Reproductive Medicine, the World Foundation for Medical Studies in Female Health and the Center for the Study of Cryopreservation of Oocytes and Spermatozoa.