Over-expression of the BRMS1 family member SUDS3 does not suppress metastasis of human cancer cells

Academic Article

Abstract

  • BRMS1 and SUDS3 are related members of SIN3-HDAC chromatin remodeling complexes. We hypothesized that they might have overlapping functions and that SUDS3 over-expression could compensate for BRMS1 deficiency. SUDS3 expression was ubiquitous in seven breast cell lines, regardless of metastatic potential. SUDS3 over-expression in BRMS1-non-expressing metastatic cells did not suppress metastasis, motility, osteopontin secretion, or EGF receptor expression, phenotypes associated with BRMS1-mediated metastasis suppression. This study demonstrates functional differences for BRMS1 family members and highlights how the composition of SIN3-HDAC (BRMS1/SUDS3) complexes uniquely affects protein expression and biological behaviors. © 2008 Elsevier Ireland Ltd. All rights reserved.
  • Published In

  • Cancer Letters  Journal
  • Digital Object Identifier (doi)

    Author List

  • Silveira AC; Hurst DR; Vaidya KS; Ayer DE; Welch DR
  • Start Page

  • 32
  • End Page

  • 37
  • Volume

  • 276
  • Issue

  • 1