Evaluation of lithium as an inhibitory agent of herpes simplex virus in cell cultures and during reactivation of latent infection in rabbits.

Academic Article

Abstract

  • Lithium carbonate inhibited plaque formation of herpes simplex virus types 1 and 2 in rabbit kidney and Vero cells (50% effective dose, 435.5 to 490 micrograms/ml). Plasma lithium levels of 67 to 134 micrograms/ml were achieved by oral therapy in rabbits. However, neither ocular virus shedding nor virus-positive trigeminal ganglia were reduced after intentional reactivation of latent herpes simplex virus infection.
  • Authors

    Published In

    Keywords

  • Animals, Herpes Simplex, Kidney, Lithium, Male, Rabbits, Recurrence, Simplexvirus, Viral Plaque Assay, Virus Cultivation
  • Digital Object Identifier (doi)

    Author List

  • Trousdale MD; Gordon YJ; Peters AC; Gropen TI; Nelson E; Nesburn AB
  • Start Page

  • 522
  • End Page

  • 523
  • Volume

  • 25
  • Issue

  • 4