A facile method for deprotection of trityl ethers using column chromatography

Academic Article


  • A mild, efficient and inexpensive detritylation method is reported that uses trifluoroacetic acid on a silica gel column to obtain pure, detritylated compounds in one-step. This method is applicable to acid stable as well as acid sensitive compounds with only slight alterations in the procedure. Nineteen examples are given. © 2001 Elsevier Science Ltd. All rights reserved.
  • Digital Object Identifier (doi)

    Author List

  • Pathak AK; Pathak V; Seitz LE; Tiwari KN; Akhtar MS; Reynolds RC
  • Start Page

  • 7755
  • End Page

  • 7757
  • Volume

  • 42
  • Issue

  • 44