Antituberculosis activity of the molecular libraries screening center network library.

Academic Article

Abstract

  • There is an urgent need for the discovery and development of new antitubercular agents that target novel biochemical pathways and treat drug-resistant forms of the disease. One approach to addressing this need is through high-throughput screening of drug-like small molecule libraries against the whole bacterium in order to identify a variety of new, active scaffolds that will stimulate additional biological research and drug discovery. Through the Molecular Libraries Screening Center Network, the NIAID Tuberculosis Antimicrobial Acquisition and Coordinating Facility tested a 215,110-compound library against Mycobacterium tuberculosis strain H37Rv. A medicinal chemistry survey of the results from the screening campaign is reported herein.
  • Published In

  • Tuberculosis  Journal
  • Keywords

  • Antitubercular Agents, Cluster Analysis, Drug Discovery, Drug Evaluation, Preclinical, Humans, Mycobacterium tuberculosis, Research, Small Molecule Libraries, Tuberculosis
  • Digital Object Identifier (doi)

    Author List

  • Maddry JA; Ananthan S; Goldman RC; Hobrath JV; Kwong CD; Maddox C; Rasmussen L; Reynolds RC; Secrist JA; Sosa MI
  • Start Page

  • 354
  • End Page

  • 363
  • Volume

  • 89
  • Issue

  • 5