Synthesis and preliminary in vitro evaluation of antimycobacterial activity of new pyrrolo[1,2-a] quinoxaline-carboxylic acid hydrazide derivatives

Academic Article

Abstract

  • New pyrrolo[1,2-α]quinoxaline-2- or -4-carboxylic acid hydrazide derivatives were synthesized from nitroaniline or 1,2-phenylenediamine, and evaluated in vitro for their antimycobacterial activity as part of a TAACF TB screening program. Two compounds 7c and 13 showed an interesting activity at 6.25 μg/mL against Mycobacterium tuberculosis H37Rv, with a 94 and 100 percentage inhibition, respectively. © 2004 Taylor & Francis Ltd.
  • Digital Object Identifier (doi)

    Author List

  • Guillon J; Reynolds RC; Leger JM; Guie MA; Massip S; Dallemagne P; Jarry C
  • Start Page

  • 489
  • End Page

  • 495
  • Volume

  • 19
  • Issue

  • 6