Arabinofuranose disaccharide analogs as inhibitors of Mycobacterium tuberculosis

Academic Article

Abstract

  • Several octyl 5-O-(α-D-arabinofuranosyl)-α-D-arabinofuranoside disaccharide analogs substituted at the 5-position of the non-reducing end sugar were synthesized and tested in vitro against Mycobacterium tuberculosis (M.tb.), Mycobacterium avium complex (MAC) as well as in a cell free assay system for arabinosyltransferase acceptor/inhibitor activity. A few compounds showed interesting inhibitory activity in the cell free assay as well as against the whole microorganism in vitro. © 2003 Elsevier Ltd. All rights reserved.
  • Digital Object Identifier (doi)

    Author List

  • Pathak AK; Pathak V; Kulshrestha M; Kinnaird D; Suling WJ; Gurcha SS; Besra GS; Reynolds RC
  • Start Page

  • 10239
  • End Page

  • 10248
  • Volume

  • 59
  • Issue

  • 51