Scleroderma: DR antigens, autoantibodies and clinical manifestations

Academic Article


  • The relationship between anticentromere antibodies (ACA), antitopoisomerase I or Scleroderma 70 (Scl-70) antibodies, HLA-DR antigens, and clinical manifestations of scleroderma were examined in 51 patients defined by ARA criteria. No association between a given HLA-DR antigen and either ACA or anti-Scl-70 was found. Statistically significant associations were noted for patients with ACA who had a lower frequency of arthritis and longer disease duration; anti-Scl-70 patients were more likely to be males with a higher frequency of pulmonary, cardiac and sicca symptoms.
  • Author List

  • Alarcon GS; McCarty GA; Lanyon P; Phillips RM; Acton RT; Barger BO
  • Start Page

  • 317
  • End Page

  • 321
  • Volume

  • 5
  • Issue

  • 4