Association of a 9.2‐kilobase pvu ii class i major histocompatibility complex restriction fragment length polymorphism with ankylosing spondylitis

Academic Article


  • We analyzed DNA restriction fragment length polymorphism (RFLP) in 53 white ankylosing spondylitis (AS) patients and 92 healthy controls, utilizing a full‐length HLA‐B7 complementary DNA probe. A 9.2‐kilobase (kb) Pvu II fragment was found to be significantly increased in frequency in B27 positive AS patients compared with the B27 positive control group (P = 0.00085, relative risk = 7.2). The presence of both B27 and the 9.2‐kb RFLP in an individual conferred a relative risk for AS of 297, compared with a relative risk of 119 in those who had B27 alone. The 9.2‐kb RFLP appears to be a marker for AS which, with HLA–B27, contributes further to susceptibility to the disease. Our findings indicate that this fragment and HLA–B27 segregate independently in familial studies of AS. Copyright © 1987 American College of Rheumatology
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    Author List

  • McDaniel DO; Acton RT; Barger BO; Koopman WJ; Reveille JD
  • Start Page

  • 894
  • End Page

  • 900
  • Volume

  • 30
  • Issue

  • 8