CD70+ antigen-presenting cells control the proliferation and differentiation of T cells in the intestinal mucosa

Academic Article

Abstract

  • One unresolved issue in gut immunity is how mucosal T lymphocytes are activated and which antigen-presenting cell (APC) is critical for the regulation of this process. We have identified a unique population of APCs that is exclusively localized in the lamina propria. These APCs constitutively expressed the costimulatory molecule CD70 and had antigen-presenting functions. After oral infection of mice with Listeria monocytogenes, proliferation and differentiation of antigen-specific T cells occurred in the gut mucosa in situ and blockade of CD70 costimulation abrogated the mucosal T cell proliferation and effector functions. Thus, a potent CD70-dependent stimulation via specialized tissue-specific APCs is required for the proliferation and differentiation of gut mucosal T cells after oral infection.
  • Published In

  • Nature Immunology  Journal
  • Digital Object Identifier (doi)

    Author List

  • Laouar A; Haridas V; Vargas D; Zhinan X; Chaplin D; Van Lier RAW; Manjunath N
  • Start Page

  • 698
  • End Page

  • 706
  • Volume

  • 6
  • Issue

  • 7