Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for Pharmacogenetics-Guided Warfarin Dosing: 2017 Update.

Academic Article

Abstract

  • This document is an update to the 2011 Clinical Pharmacogenetics Implementation Consortium (CPIC) guideline for CYP2C9 and VKORC1 genotypes and warfarin dosing. Evidence from the published literature is presented for CYP2C9, VKORC1, CYP4F2, and rs12777823 genotype-guided warfarin dosing to achieve a target international normalized ratio of 2-3 when clinical genotype results are available. In addition, this updated guideline incorporates recommendations for adult and pediatric patients that are specific to continental ancestry.
  • Authors

    Keywords

  • Adult, Anticoagulants, Child, Cytochrome P-450 CYP2C9, Cytochrome P450 Family 4, Dose-Response Relationship, Drug, Genotype, Humans, Pharmacogenetics, Practice Guidelines as Topic, Vitamin K Epoxide Reductases, Warfarin
  • Digital Object Identifier (doi)

    Author List

  • Johnson JA; Caudle KE; Gong L; Whirl-Carrillo M; Stein CM; Scott SA; Lee MT; Gage BF; Kimmel SE; Perera MA
  • Start Page

  • 397
  • End Page

  • 404
  • Volume

  • 102
  • Issue

  • 3