The Sec7 guanine nucleotide exchange factor GBF1 regulates membrane recruitment of BIG1 and BIG2 guanine nucleotide exchange factors to the trans-Golgi network (TGN)

Academic Article


  • Background: GBF1, BIG1, and BIG2 are guanine nucleotide exchange factors (GEFs) that activate ARFs to regulate secretory traffic. Results: GBF1 activity promotes subsequent recruitment of BIG1/2. Conclusion: The three GEFs are functionally coupled in a GEF/ARF/GEF cascade. Significance: Coupling integrates all coating events within the pathway to simultaneously regulate passage of cargo through multiple compartments. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.
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    Digital Object Identifier (doi)

    Author List

  • Lowery J; Szul T; Styers M; Holloway Z; Oorschot V; Klumperman J; Sztul E
  • Start Page

  • 11532
  • End Page

  • 11545
  • Volume

  • 288
  • Issue

  • 16