Seed-weighted random walk ranking for cancer biomarker prioritisation: A case study in leukaemia

Academic Article

Abstract

  • A central focus of clinical proteomics for cancer is to identify protein biomarkers with diagnostic and therapeutic application potential. Network-based analyses have been used in computational disease-related gene prioritisation for several years. The Random Walk Ranking (RWR) algorithm has been successfully applied to prioritising disease-related gene candidates by exploiting global network topology in a Protein-Protein Interaction (PPI) network. Increasing the specifi city and sensitivity of biomarkers may require consideration of similar or closely-related disease phenotypes and molecular pathological mechanisms shared across different disease phenotypes. In this paper, we propose a method called Seed-Weighted Random Walk Ranking (SW-RWR) for prioritizing cancer biomarker candidates. This method uses the information of cancer phenotype association to assign to each gene a disease-specifi c, weighted value to guide the RWR algorithm in a global human PPI network. In a case study of prioritizing leukaemia biomarkers, SW-RWR outperformed a typical local network-based analysis in coverage and also showed better accuracy and sensitivity than the original RWR method (global networkbased analysis). Our results suggest that the tight correlation among different cancer phenotypes could play an important role in cancer biomarker discovery.Copyright © 2014 Inderscience Enterprises Ltd.
  • Digital Object Identifier (doi)

    Author List

  • Huan T; Wu X; Bai Z; Chen JY
  • Start Page

  • 135
  • End Page

  • 148
  • Volume

  • 9
  • Issue

  • 2