Reversal of neurobehavioral social deficits in dystrophic mice using inhibitors of phosphodiesterases PDE5A and PDE9A

Academic Article

Abstract

  • © The Author(s) 2016. Duchenne muscular dystrophy is caused by mutations in the DYSTROPHIN gene. Although primarily associated with muscle wasting, a significant portion of patients (approximately 25%) are also diagnosed with autism spectrum disorder. We describe social behavioral deficits in dystrophin-deficient mice and present evidence of cerebellar deficits in cGMP production. We demonstrate therapeutic potential for selective inhibitors of the cGMP-specific PDE5A and PDE9A enzymes to restore social behaviors in dystrophin-deficient mice.
  • Digital Object Identifier (doi)

    Author List

  • Alexander MS; Gasperini MJ; Tsai PT; Gibbs DE; Spinazzola JM; Marshall JL; Feyder MJ; Pletcher MT; Chekler ELP; Morris CA
  • Volume

  • 6
  • Issue

  • 9