Feasibility of Mid-Frequency Ventilation Among Infants With Respiratory Distress Syndrome.

Academic Article


  • BACKGROUND: Mid-frequency ventilation, a strategy of using conventional ventilators at high frequencies, may reduce lung injury but has had limited evaluation in neonates. Hence, a randomized crossover study was designed to assess the feasibility of using mid-frequency ventilation in preterm infants with respiratory distress syndrome. METHODS: Twelve preterm infants (≥500 g and ≥24 weeks gestational age) who were receiving pressure-limited conventional ventilation with frequencies ≤60 breaths/min for respiratory distress syndrome were randomized to periods of mid-frequency ventilation (conventional ventilation with the fastest frequency up to 150 breaths/min that gave complete inspiration and expiration) or conventional ventilation (frequency ≤60 breaths/min), each lasting 2 h using a crossover design. Ventilator parameters were adjusted to maintain the O2 saturation and transcutaneous CO2 at baseline. RESULTS: Mean peak inspiratory pressure (15 ± 4 cm H2O vs 18 ± 4 cm H2O, P < .001), Δ pressure (9.8 ± 3.3 cm H2O vs 13.5 ± 3.9 cm H2O, P < .001), and tidal volume (2.6 ± 0.4 mL/kg vs 4.6 ± 0.8 mL/kg, P < .001) were lower, but mean airway pressure (8.9 ± 1.9 cm H2O vs 8.4 ± 1.6 cm H2O, P = .02) and measured PEEP (5.1 ± 0.5 cm H2O vs 4.4 ± 0.5 cm H2O, P < .001) were higher with mid-frequency compared with conventional ventilation. FIO2, gas exchange, and hemodynamic parameters were not affected. CONCLUSIONS: Based on this small study, mid-frequency ventilation among preterm infants with respiratory distress syndrome is feasible. Further larger and longer duration trials are necessary to validate our findings. (ClinicalTrials.gov registration NCT01242462).
  • Published In

  • Respiratory Care  Journal
  • Keywords

  • mechanical ventilation, preterm, respiratory distress syndrome, ventilator-induced lung injury, Cross-Over Studies, Feasibility Studies, Female, Humans, Infant, Newborn, Male, Maximal Respiratory Pressures, Positive-Pressure Respiration, Pulmonary Gas Exchange, Respiration, Artificial, Respiratory Distress Syndrome, Newborn, Tidal Volume, Treatment Outcome
  • Digital Object Identifier (doi)

    Author List

  • Bhat R; Kelleher J; Ambalavanan N; Chatburn RL; Mireles-Cabodevila E; Carlo WA
  • Start Page

  • 481
  • End Page

  • 488
  • Volume

  • 62
  • Issue

  • 4