This article described the roles of the occupational therapist in developing self-care interventions for adults with brain damage and behavioral involvement. Interventions were based on the neurofunctional model suggested by Giles and Clark-Wilson (1993). Interventions incorporated psycho-social, cognitive, and functional training, and a total learning environment unique to occupational therapy. The treatment goals were to help the adults with brain damage learn, adjust and/or readapt so that they could function in their discharge environments with minimal supervision. Two case studies are used to illustrate the application of this model. © 1994 by The Haworth Press, Inc. All rights reserved.