Performance of a T-cell-based diagnostic test for tuberculosis infection in HIV-infected individuals is independent of CD4 cell count

Academic Article


  • The performance characteristics of the enzyme-linked immunospot assay (ELISPOT) assay (T-SPOT TB) for the diagnosis of latent tuberculosis infection in HIV-infected individuals are unknown. Given that ELISPOT enumerates Mycobacterium tuberculosis antigen-specific IFN-γ-secreting T cells, HIV-associated immunosuppression might adversely affect test performance. However, we found that 28 out of 29 HIV-positive individuals (97%) gave evaluable test results, and performance was independent of the CD4 T-cell count. ELISPOT test performance appears to be independent of HIV-associated immunosuppression.
  • Authors

    Published In

  • AIDS  Journal
  • Digital Object Identifier (doi)

    Pubmed Id

  • 9176705
  • Author List

  • Dheda K; Lalvani A; Miller RF; Scott G; Booth H; Johnson MA; Zumla A; Rook GAW
  • Start Page

  • 2038
  • End Page

  • 2041
  • Volume

  • 19
  • Issue

  • 17