Structural studies on conformationally defined 6-s-trans UAB retinoids

Academic Article

Abstract

  • The calculated structures of ten conformationally defined 6-s-trans retinoids are reported here. These compounds are precursors and intermediates in the synthesis of biologically active derivatives of retinoic acid. Of particular interest are the ring geometries in these compounds because of their importance in the interaction of the derivatives with the binding site of the receptors. The ring conformation in these compounds depends primarily on two specific sites of steric interaction. © 2001 Elsevier Science B.V.
  • Digital Object Identifier (doi)

    Author List

  • Ponder MS; Alan Long J; Williams LM; Hamilton TP; Muccio DD
  • Start Page

  • 39
  • End Page

  • 45
  • Volume

  • 549
  • Issue

  • 1-2