Details of the synthesis of the E isomer of 3-(2,5-dimethoxyphenyl)-2-(4- methoxyphenyl)acrylonitrile, and the X-ray crystal structures of both the E and Z isomers of this compound are presented. The E isomer crystallizes in the P2 /c space group with cell parameters, a = 8.5659(17) Å, b = 16.399(3) Å, c = 11.224(2) Å, α = 90°, β = 95.27(3)°, γ = 90°and Z = 4. The Z isomer crystallizes in the Pca2 space group with cell parameters, a = 4.1223(8) Å, b = 19.113(4) Å, c = 19.453(4) Å, α = 90°, β = 90°, γ = 90° and Z = 4. © 2007 Springer Science+Business Media, LLC. 1 1