Positions

Overview

  • I am a Biomedical Engineer by training with a PhD from the University of Michigan where I worked with Dr. Carlos, H. Mastrangelo developing new polymer based lab-on-a-chip technologies for genomic and proteomic assays. I completed my postdoctoral training in the laboratory of Dr. Mehmet Toner at the Center for Engineering in Medicine at Massachusetts General Hospital, Harvard Medical School and Shriners Burns Hospital working on label-free approaches to isolate leukocyte sub-populations from whole blood. After spending the 1st 7 years of my career at the University of Louisville, I am currently an Associate Professor of Medicine and Biomedical Engineering within the Division of Cardiovascular Disease at the University of Alabama-Birmingham.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2019 Growing Human Parathyroids in a Microphysiological System: A Novel Approach to Understanding and Developing New Treatments for Hyperparathyroidism 2019
    2019 Hemodynamic Stimulation Using the Biomimetic Cardiac Tissue Model (BCTM) Enhances Maturation of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes 2019
    2019 Evaluation of flow-modulation approaches in ventricular assist devices using an in-vitro endothelial cell culture model 2019
    2019 Mitoquinone ameliorates pressure overload-induced cardiac fibrosis and left ventricular dysfunction in mice 2019
    2018 Low-stress Microfluidic Density-gradient Centrifugation for Blood Cell Sorting 2018
    2018 Review: Microfluidics technologies for blood-based cancer liquid biopsies 2018
    2017 Elucidation of dose-dependent transcriptional events immediately following ionizing radiation exposure 2017
    2017 Microfluidic adaptation of density-gradient centrifugation for isolation of particles and cells 2017
    2016 Biomimetic Cardiac Tissue Model Enables the Adaption of Human Induced Pluripotent Stem Cell Cardiomyocytes to Physiological Hemodynamic Loads 2016
    2016 A biphasic effect of TNF-α in regulation of the Keap1/Nrf2 pathway in cardiomyocytes 2016
    2016 In vitro osteocytic microdamage and viability quantification using a microloading platform 2016
    2016 Nanofiber and stem cell enabled biomimetic systems and regenerative medicine 2016
    2016 Evaluation of the effect of diminished pulsatility as seen in continuous flow ventricular assist devices on arterial endothelial cell phenotype and function 2016
    2016 Abrogation of Nrf2 impairs antioxidant signaling and promotes atrial hypertrophy in response to high-intensity exercise stress 2016
    2016 Impact of Gap Junctional Intercellular Communication on MLO-Y4 Sclerostin and Soluble Factor Expression 2016
    2016 Transcriptional profile of immediate response to ionizing radiation exposure 2016
    2016 Lab-on-a-brane: Nanofibrous polymer membranes to recreate organ-capillary interfaces 2016
    2015 In Vitro Evaluation of the Link Between Cell Activation State and Its Rheological Impact on the Microscale Flow of Neutrophil Suspensions 2015
    2015 Effects of physiologic mechanical stimulation on embryonic chick cardiomyocytes using a microfluidic cardiac cell culture model 2015
    2014 Hyperglycemic arterial disturbed flow niche as an in vitro model of atherosclerosis 2014
    2014 Thermally induced substrate release via intramolecular cyclizations of Amino esters and Amino carbonates 2014
    2014 Shear-sensitive regulation of neutrophil flow behavior and its potential impact on microvascular blood flow dysregulation in hypercholesterolemia 2014
    2014 A microfluidics-based technique for automated and rapid labeling of cells for flow cytometry 2014
    2013 Cardiac cell culture model as a left ventricle mimic for cardiac tissue generation 2013
    2013 A new technique for reversible permeabilization of live cells for intracellular delivery of quantum dots 2013
    2013 Robustness of Helicobacter pylori Infection Conferred by Context-Variable Redundancy among Cysteine-Rich Paralogs 2013
    2013 Microfluidic inertia enhanced phase partitioning for enriching nucleated cell populations in blood 2013
    2012 Osteocyte characterization on polydimethylsiloxane substrates for microsystems applications 2012
    2012 Mechanisms of Periodic Acceleration Induced Endothelial Nitric Oxide Synthase (eNOS) Expression and Upregulation Using an In Vitro Human Aortic Endothelial Cell Model 2012
    2012 Inertial lift enhanced phase partitioning for continuous microfluidic surface energy based sorting of particles 2012
    2012 Clinical neuroproteomics and biomarkers: from basic research to clinical decision making. 2012
    2011 Evaluation of the direct and indirect response of blood leukocytes to carbon nanotubes (CNTs) 2011
    2011 Gold nanoprobes for theranostics 2011
    2011 Clinical neuroproteomics and biomarkers: From basic research to clinical decision-making 2011
    2011 Exploiting osmosis for blood cell sorting 2011
    2011 Endothelial cell culture model for replication of physiological profiles of pressure, flow, stretch, and shear stress in vitro 2011
    2011 Elastic phantoms generated by microfluidics technology: Validation of an imaged-based approach for accurate measurement of the growth rate of lung nodules 2011
    2011 Endothelial cell culture model of carotid artery atherosclerosis. 2011
    2011 Meta-analysis of gene expression changes in response to radiation exposure 2011
    2011 Microfluidic endothelial cell culture model to replicate disturbed flow conditions seen in atherosclerosis susceptible regions 2011
    2010 Micro- and nanotechnology approaches for capturing circulating tumor cells 2010
    2010 Microfluidic Cardiac Cell Culture Model (μCCCM) 2010
    2010 Automated microfluidic blood lysis protocol for enrichment of circulating nucleated cells 2010
    2009 Microfluidic cardiac circulation model (μCCM) for functional cardiomyocyte studies 2009
    2009 Clinical application of microfluidic leukocyte enrichment protocol in mild phenotype sickle cell disease (SCD) 2009
    2008 Three-dimensional hydrodynamic focusing in a microfluidic Coulter counter 2008
    2008 Microfluidic leukocyte isolation for gene expression analysis in critically ill hospitalized patients 2008
    2007 Osmotic selection of human mesenchymal stem/progenitor cells from umbilical cord blood 2007
    2006 Size-based microfluidic enrichment of neonatal rat cardiac cell populations 2006
    2006 Microfluidic isolation of leukocytes from whole blood for phenotype and gene expression analysis 2006
    2006 Microfluidic diffusive filter for apheresis (leukapheresis) 2006
    2004 Continuous flow microfluidic device for rapid erythrocyte lysis 2004
    2004 Cast epoxy-based microfluidic systems and their application in biotechnology 2004
    2003 Polyethylene glycol (PEG)-based actuator for nozzle-diffuser pumps in plastic microfluidic systems 2003

    Chapter

    Year Title Altmetric
    2016 Validation of a new image-based approach for the accurate estimating of the growth rate of detected lung nodules using real computed tomography images and elastic phantoms generated by state-of-the-art microfluidics technology.  405-420. 2016
    2013 Connecting microbial population genetics with microbial pathogenesis: Engineering microfluidic cell arrays for high-throughput interrogation of host-pathogen interaction.  745-760. 2013
    2011 Connecting microbial population genetics with microbial pathogenesis: Engineering microfluidic cell arrays for high-throughput interrogation of host-pathogen interaction.  533-548. 2011

    Research Overview

  • My laboratory pioneered Cardiac and Vascular Tissue Chip Models (BCTM and VPPM) which represent the state-of-the art for culture of cardiac and vascular cells in-vitro. As a Biomedical Engineer, I have extensive experience in the areas of tissue engineering and fluid mechanics, which has enabled me to design and construct systems for culture of cells in environments that mimic the complex hemodynamic stresses in cardiac and vascular tissues. Recently, we have expanded our work to build tissue chip models of the Kidney focusing on drug induced nephrotoxicity. My laboratory has been funded by major federal funding agencies including NIH, NSF, DoD and NASA and private foundations like the Alabama Institute of Medicine, Kentucky Science and Technology Foundation and the Wallace H. Coulter Foundation. I have successfully administered projects, collaborated with other researchers, and produced several peer-reviewed publications from each project.
  • Teaching Overview

  • I have extensive teaching experience that includes courses within the core Biomedical Engineering Curriculum (i.e) Biomechanics Principles and Biotransport Phenomena and elective courses such as Biomechanics of Organs and Tissue, Cardiovascular Dynamics, Advanced Biotransport, Molecular and Tissue Engineering Laboratory, and Biomedical Microfluidics.
  • Teaching Activities

  • BME798 - Non-Dissertation Research (Fall Term 2019) 2019
  • BME798 - Non-Dissertation Research (Summer Term 2019) 2019
  • BME350 - Biological Transport Phenomena (Spring Term 2019) 2019
  • BME798 - Non-Dissertation Research (Spring Term 2019) 2019
  • BME699 - Masters Thesis Research (Summer Term 2018) 2018
  • BME799 - Dissertation Research (Summer Term 2018) 2018
  • BME350 - Biological Transport Phenomena (Spring Term 2018) 2018
  • BME699 - Masters Thesis Research (Spring Term 2018) 2018
  • BME699 - Masters Thesis Research (Spring Term 2018) 2018
  • BME799 - Dissertation Research (Spring Term 2018) 2018
  • BME698 - Non-Thesis Research (Fall Term 2017) 2017
  • BME798 - Non-Dissertation Research (Fall Term 2017) 2017
  • BME799 - Dissertation Research (Fall Term 2017) 2017
  • BME698 - Non-Thesis Research (Summer Term 2017) 2017
  • BME798 - Non-Dissertation Research (Summer Term 2017) 2017
  • BME799 - Dissertation Research (Summer Term 2017) 2017
  • BME350 - Biological Transport Phenomena (Spring Term 2017) 2017
  • BME691 - Individual Study in (Area) (Spring Term 2017) 2017
  • BME698 - Non-Thesis Research (Spring Term 2017) 2017
  • BME798 - Non-Dissertation Research (Spring Term 2017) 2017
  • BME698 - Non-Thesis Research (Fall Term 2016) 2016
  • BME798 - Non-Dissertation Research (Fall Term 2016) 2016
  • BME698 - Non-Thesis Research (Summer Term 2016) 2016
  • BME798 - Non-Dissertation Research (Summer Term 2016) 2016
  • BME350 - Biological Transport Phenomena (Spring Term 2016) 2016
  • BME798 - Non-Dissertation Research (Spring Term 2016) 2016
  • BME698 - Non-Thesis Research (Fall Term 2015) 2015
  • BME798 - Non-Dissertation Research (Fall Term 2015) 2015
  • BME698 - Non-Thesis Research (Summer Term 2015) 2015
  • BME699 - Masters Thesis Research (Summer Term 2015) 2015
  • BME798 - Non-Dissertation Research (Summer Term 2015) 2015
  • BME350 - Biological Transport Phenomena (Spring Term 2015) 2015
  • BME698 - Non-Thesis Research (Spring Term 2015) 2015
  • BME699 - Masters Thesis Research (Spring Term 2015) 2015
  • BME798 - Non-Dissertation Research (Spring Term 2015) 2015
  • BME408 - Biofluids (Fall Term 2014) 2014
  • BME491 - Individual Study in BME (Fall Term 2014) 2014
  • BME508 - Biofluids (Fall Term 2014) 2014
  • BME698 - Non-Thesis Research (Fall Term 2014) 2014
  • BME798 - Non-Dissertation Research (Fall Term 2014) 2014
  • BME798 - Non-Dissertation Research (Summer Term 2014) 2014
  • Education And Training

  • Harvard Medical School, Massachusetts General Hospital and Shriners Burns Hospital Surgery, Postdoctoral Fellowship 2019
  • Full Name

  • Palaniappan Sethu