Positions

Selected Publications

Academic Article

Year Title Altmetric
2019 Evaluation of flow-modulation approaches in ventricular assist devices using an in-vitro endothelial cell culture modelThe Journal of heart transplantation.  38:456-465. 2019
2019 Mitoquinone ameliorates pressure overload-induced cardiac fibrosis and left ventricular dysfunction in miceRedox Biology.  21. 2019
2019 Hemodynamic Stimulation Using the Biomimetic Cardiac Tissue Model (BCTM) Enhances Maturation of Human Induced Pluripotent Stem Cell-Derived CardiomyocytesCells Tissues Organs2019
2018 Low-stress Microfluidic Density-gradient Centrifugation for Blood Cell SortingBiomedical Microdevices.  20. 2018
2018 Review: Microfluidics technologies for blood-based cancer liquid biopsiesAnalytica Chimica Acta.  1012:10-29. 2018
2018 Growing Human Parathyroids in a Microphysiological System: A Novel Approach to Understanding and Developing New Treatments for HyperparathyroidismCells Tissues Organs2018
2017 Microfluidic Adaptation of Density-Gradient Centrifugation for Isolation of Particles and Cells.Bioengineering.  4. 2017
2016 Biomimetic Cardiac Tissue Model Enables the Adaption of Human Induced Pluripotent Stem Cell Cardiomyocytes to Physiological Hemodynamic LoadsAnalytical Chemistry.  88:9862-9868. 2016
2016 In vitro osteocytic microdamage and viability quantification using a microloading platformMedical Engineering and Physics.  38:1115-1122. 2016
2016 Nanofiber and stem cell enabled biomimetic systems and regenerative medicineJournal of Nanoscience and Nanotechnology.  16:8923-8934. 2016
2016 Evaluation of the effect of diminished pulsatility as seen in continuous flow ventricular assist devices on arterial endothelial cell phenotype and functionThe Journal of heart transplantation.  35:930-932. 2016
2016 Impact of Gap Junctional Intercellular Communication on MLO-Y4 Sclerostin and Soluble Factor ExpressionAnnals of Biomedical Engineering.  44:1170-1180. 2016
2016 Transcriptional profile of immediate response to ionizing radiation exposureGenomics Data.  7:82-85. 2016
2016 Lab-on-a-brane: Nanofibrous polymer membranes to recreate organ-capillary interfacesJournal of Micromechanics and Microengineering.  26. 2016
2015 In Vitro Evaluation of the Link Between Cell Activation State and Its Rheological Impact on the Microscale Flow of Neutrophil SuspensionsJournal of Biomechanical Engineering.  137. 2015
2015 Effects of physiologic mechanical stimulation on embryonic chick cardiomyocytes using a microfluidic cardiac cell culture modelAnalytical Chemistry.  87:2107-2113. 2015
2014 Hyperglycemic arterial disturbed flow niche as an in vitro model of atherosclerosisAnalytical Chemistry.  86:10948-10954. 2014
2014 Thermally induced substrate release via intramolecular cyclizations of Amino esters and Amino carbonatesTetrahedron.  70:3422-3429. 2014
2014 Shear-sensitive regulation of neutrophil flow behavior and its potential impact on microvascular blood flow dysregulation in hypercholesterolemiaArteriosclerosis, Thrombosis, and Vascular Biology.  34:587-593. 2014
2014 A microfluidics-based technique for automated and rapid labeling of cells for flow cytometryJournal of Micromechanics and Microengineering.  24. 2014
2013 Cardiac cell culture model as a left ventricle mimic for cardiac tissue generationAnalytical Chemistry.  85:8773-8779. 2013
2013 A new technique for reversible permeabilization of live cells for intracellular delivery of quantum dotsNanotechnology.  24. 2013
2013 Robustness of Helicobacter pylori Infection Conferred by Context-Variable Redundancy among Cysteine-Rich ParalogsPLoS ONE.  8. 2013
2013 Microfluidic inertia enhanced phase partitioning for enriching nucleated cell populations in bloodLab on a Chip.  13:892-900. 2013
2012 Osteocyte characterization on polydimethylsiloxane substrates for microsystems applicationsJournal of Biomimetics, Biomaterials, and Tissue Engineering.  16:27-42. 2012
2012 Mechanisms of Periodic Acceleration Induced Endothelial Nitric Oxide Synthase (eNOS) Expression and Upregulation Using an In Vitro Human Aortic Endothelial Cell ModelCardiovascular Engineering and Technology.  3:292-301. 2012
2012 Inertial lift enhanced phase partitioning for continuous microfluidic surface energy based sorting of particlesLab on a Chip.  12:1296-1301. 2012
2012 Clinical neuroproteomics and biomarkers: from basic research to clinical decision making.Neurosurgery.  70:518-525. 2012
2011 Endothelial cell culture model of carotid artery atherosclerosisConference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference.  186-189. 2011
2011 Evaluation of the direct and indirect response of blood leukocytes to carbon nanotubes (CNTs)Nanomedicine: Nanotechnology, Biology and Medicine.  7:983-991. 2011
2011 Gold nanoprobes for theranosticsNanomedicine.  6:1787-1811. 2011
2011 Microfluidic endothelial cell culture model to replicate disturbed flow conditions seen in atherosclerosis susceptible regionsBiomicrofluidics.  5. 2011
2011 Clinical neuroproteomics and biomarkers: From basic research to clinical decision-makingNeurosurgery2011
2011 Exploiting osmosis for blood cell sortingBiomedical Microdevices.  13:453-462. 2011
2011 Endothelial cell culture model for replication of physiological profiles of pressure, flow, stretch, and shear stress in vitroAnalytical Chemistry.  83:3170-3177. 2011
2011 Elastic phantoms generated by microfluidics technology: Validation of an imaged-based approach for accurate measurement of the growth rate of lung nodulesBiotechnology Journal.  6:195-203. 2011
2011 Meta-analysis of gene expression changes in response to radiation exposureBMC Bioinformatics.  12:A20-A20. 2011
2010 Micro- and nanotechnology approaches for capturing circulating tumor cellsCancer Nanotechnology.  1:3-11. 2010
2010 Microfluidic Cardiac Cell Culture Model (μCCCM)Analytical Chemistry.  82:7581-7587. 2010
2010 Automated microfluidic blood lysis protocol for enrichment of circulating nucleated cellsJournal of Visualized Experiments2010
2009 Microfluidic cardiac circulation model (μCCM) for functional cardiomyocyte studiesProceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009.  1060-1063. 2009
2009 Clinical application of microfluidic leukocyte enrichment protocol in mild phenotype sickle cell disease (SCD)Biomedical Microdevices.  11:477-483. 2009
2008 Three-dimensional hydrodynamic focusing in a microfluidic Coulter counterReview of Scientific Instruments.  79. 2008
2008 Microfluidic leukocyte isolation for gene expression analysis in critically ill hospitalized patientsClinical Chemistry.  54:891-900. 2008
2007 Osmotic selection of human mesenchymal stem/progenitor cells from umbilical cord bloodTissue Engineering -Larchmont-.  13:2465-2473. 2007
2006 Size-based microfluidic enrichment of neonatal rat cardiac cell populationsBiomedical Microdevices.  8:231-237. 2006
2006 Microfluidic isolation of leukocytes from whole blood for phenotype and gene expression analysisAnalytical Chemistry.  78:5453-5461. 2006
2006 Microfluidic diffusive filter for apheresis (leukapheresis)Lab on a Chip.  6:83-89. 2006
2004 Continuous flow microfluidic device for rapid erythrocyte lysisAnalytical Chemistry.  76:6247-6253. 2004
2004 Cast epoxy-based microfluidic systems and their application in biotechnologySensors and Actuators B: Chemical.  98:337-346. 2004
2003 Polyethylene glycol (PEG)-based actuator for nozzle-diffuser pumps in plastic microfluidic systemsSensors and Actuators A: Physical.  104:283-289. 2003

Chapter

Year Title Altmetric
2016 Validation of a new image-based approach for the accurate estimating of the growth rate of detected lung nodules using real computed tomography images and elastic phantoms generated by state-of-the-art microfluidics technology.  405-420. 2016
2013 Connecting microbial population genetics with microbial pathogenesis: Engineering microfluidic cell arrays for high-throughput interrogation of host-pathogen interaction.  745-760. 2013
2011 Connecting microbial population genetics with microbial pathogenesis: Engineering microfluidic cell arrays for high-throughput interrogation of host-pathogen interaction.  533-548. 2011

Teaching Activities

  • BME350 - Biological Transport Phenomena (Spring Term 2019) 2019
  • BME798 - Non-Dissertation Research (Spring Term 2019) 2019
  • BME699 - Masters Thesis Research (Summer Term 2018) 2018
  • BME799 - Dissertation Research (Summer Term 2018) 2018
  • BME350 - Biological Transport Phenomena (Spring Term 2018) 2018
  • BME699 - Masters Thesis Research (Spring Term 2018) 2018
  • BME699 - Masters Thesis Research (Spring Term 2018) 2018
  • BME799 - Dissertation Research (Spring Term 2018) 2018
  • BME698 - Non-Thesis Research (Fall Term 2017) 2017
  • BME798 - Non-Dissertation Research (Fall Term 2017) 2017
  • BME799 - Dissertation Research (Fall Term 2017) 2017
  • BME698 - Non-Thesis Research (Summer Term 2017) 2017
  • BME798 - Non-Dissertation Research (Summer Term 2017) 2017
  • BME799 - Dissertation Research (Summer Term 2017) 2017
  • BME350 - Biological Transport Phenomena (Spring Term 2017) 2017
  • BME691 - Individual Study in (Area) (Spring Term 2017) 2017
  • BME698 - Non-Thesis Research (Spring Term 2017) 2017
  • BME798 - Non-Dissertation Research (Spring Term 2017) 2017
  • BME698 - Non-Thesis Research (Fall Term 2016) 2016
  • BME798 - Non-Dissertation Research (Fall Term 2016) 2016
  • BME698 - Non-Thesis Research (Summer Term 2016) 2016
  • BME798 - Non-Dissertation Research (Summer Term 2016) 2016
  • BME350 - Biological Transport Phenomena (Spring Term 2016) 2016
  • BME798 - Non-Dissertation Research (Spring Term 2016) 2016
  • BME698 - Non-Thesis Research (Fall Term 2015) 2015
  • BME798 - Non-Dissertation Research (Fall Term 2015) 2015
  • BME698 - Non-Thesis Research (Summer Term 2015) 2015
  • BME699 - Masters Thesis Research (Summer Term 2015) 2015
  • BME798 - Non-Dissertation Research (Summer Term 2015) 2015
  • BME350 - Biological Transport Phenomena (Spring Term 2015) 2015
  • BME698 - Non-Thesis Research (Spring Term 2015) 2015
  • BME699 - Masters Thesis Research (Spring Term 2015) 2015
  • BME798 - Non-Dissertation Research (Spring Term 2015) 2015
  • BME408 - Biofluids (Fall Term 2014) 2014
  • BME491 - Individual Study in BME (Fall Term 2014) 2014
  • BME508 - Biofluids (Fall Term 2014) 2014
  • BME698 - Non-Thesis Research (Fall Term 2014) 2014
  • BME798 - Non-Dissertation Research (Fall Term 2014) 2014
  • BME798 - Non-Dissertation Research (Summer Term 2014) 2014
  • Education And Training

  • Doctor of Philosophy in Biomedical / Medical Engineering, University of Michigan System : Ann Arbor 2002
  • Master of Sciences or Mathematics in Biomedical / Medical Engineering, University of Michigan System : Ann Arbor 1998
  • Full Name

  • Palaniappan Sethu