Positions

Selected Publications

Academic Article

Year Title Altmetric
2019 Crystal structure of a ligand-free stable TSH receptor leucine-rich repeat domain 2019
2019 Plasma xanthine oxidase activity is related to increased sodium and left ventricular hypertrophy in resistant hypertension 2019
2019 Correction to: The evaluation of monoclonal gammopathy of renal significance: a consensus report of the International Kidney and Monoclonal Gammopathy Research Group (Nature Reviews Nephrology, (2019), 15, 1, (45-59), 10.1038/s41581-018-0077-4) 2019
2019 Immunoglobulin light chains generate proinflammatory and profibrotic kidney injury 2019
2019 Sodium and potassium excretion predict increased depression in urban adolescents 2019
2019 The evaluation of monoclonal gammopathy of renal significance: a consensus report of the International Kidney and Monoclonal Gammopathy Research Group 2019
2018 Changing paradigms in acute kidney injury: From mechanisms to management: Proceedings of the 8th annual UAB-UCSD O'brien center symposium 2018
2018 Animal models of monoclonal immunoglobulin-related renal diseases 2018
2017 Changing Paradigms in Acute Kidney Injury: From Mechanisms to Management 2017
2017 Haploinsufficiency of the Transcription Factor Ets-1 Is renoprotective in dahl salt-sensitive rats 2017
2017 Dietary potassium regulates vascular calcification and arterial stiffness. 2017
2017 Novel paradigms of salt and hypertension 2017
2016 Changing Paradigms in Acute Kidney Injury: From Mechanisms to Management 2016
2016 Family history of hematologic malignancies and risk of multiple myeloma: differences by race and clinical features 2016
2016 Paraprotein-related kidney disease: Kidney injury from paraproteins—What determines the site of injury? 2016
2015 Transforming growth factor-β mediates endothelial dysfunction in rats during high salt intake 2015
2015 The use of immunoglobulin light chain assays in the diagnosis of paraprotein-related kidney disease 2015
2015 PPARγ agonist-induced fluid retention depends on αENaC expression in connecting tubules 2015
2015 Reply 2015
2015 Transcription factor avian erythroblastosis virus E26 oncogen homolog-1 is a novel mediator of renal injury in salt-sensitive hypertension 2015
2014 Sodium and potassium regulate endothelial phospholipase C-γ and Bmx 2014
2014 Spironolactone use and higher hospital readmission for medicare beneficiaries with heart failure, left ventricular ejection fraction <45%, and estimated glomerular filtration rate <45 ml/min/1.73 m2 2014
2014 Community mobility among older adults with reduced kidney function: A study of life-space 2014
2014 Changing paradigms in acute kidney injury: From mechanisms to management - Proceedings of the 5th annual UAB-UCSD O'Brien center symposium (San Diego, Calif., USA, March 4, 2014) 2014
2014 Distinct populations of label-retaining cells in the adult kidney are defined temporally and exhibit divergent regional distributions 2014
2014 In replydpopulation-wide sodium reduction: Reasons to resist 2014
2014 Nitric oxide and carbon monoxide antagonize TGF-β through ligandindependent internalization of TβR1/ALK5 2014
2013 Transforming growth factor-β regulates endothelial function during high salt intake in rats 2013
2013 Beware the low HDAC11: Males at risk for ischemic kidney injury 2013
2013 Dietary potassium: A key mediator of the cardiovascular response to dietary sodium chloride 2013
2013 Hypertensive Nephrosclerosis: Not enough of a good thing? 2013
2013 Effects of enalapril in systolic heart failure patients with and without chronic kidney disease: Insights from the SOLVD Treatment trial 2013
2013 Renin-angiotensin inhibition in diastolic heart failure and chronic kidney disease 2013
2013 High dietary sodium intake impairs endothelium-dependent dilation in healthy salt-resistant humans 2013
2013 KDOQI US commentary on the 2012 KDIGO clinical practice guideline for management of blood pressure in CKD 2013
2013 Role of dietary salt and potassium intake in cardiovascular health and disease: A review of the evidence 2013
2012 A reproducible mouse model of chronic allograft nephropathy with vasculopathy 2012
2012 Effect of Aging and Dietary Salt and Potassium Intake on Endothelial PTEN (Phosphatase and Tensin Homolog on Chromosome 10) Function 2012
2012 Dietary sodium loading impairs microvascular function independent of blood pressure in humans: Role of oxidative stress 2012
2012 Mechanisms of light chain injury along the tubular nephron 2012
2012 Similarities and differences in interactions of thyroid stimulating and blocking autoantibodies with the TSH receptor 2012
2012 Evolving Strategies in the Diagnosis, Treatment, and Monitoring of Myeloma Kidney 2012
2012 Effect of Dietary Salt on Regulation of TGF-β in the Kidney 2012
2012 Mechanism and prevention of acute kidney injury from cast nephropathy in a rodent model 2012
2012 In vivo effects of a human thyroid-stimulating monoclonal autoantibody (M22) and a human thyroid-blocking autoantibody (K1-70) 2012
2012 Renin-angiotensin inhibition in systolic heart failure and chronic kidney disease 2012
2012 Enabling Innovative Translational Research in Acute Kidney Injury 2012
2012 Pivotal role of apoptosis signal-regulating kinase 1 in monoclonal free light chain-mediated apoptosis 2012
2012 The pathogenesis and diagnosis of acute kidney injury in multiple myeloma 2012
2011 A propensity-matched study of the comparative effectiveness of angiotensin receptor blockers versus angiotensin-converting enzyme inhibitors in heart failure patients age <65 years 2011
2011 Association of dietary sodium and potassium intakes with albuminuria in normal-weight, overweight, and obese participants in the Reasons for Geographic and Racial Differences in Stroke (REGARDS) study 2011
2011 Relationship between stage of kidney disease and incident heart failure in older adults 2011
2011 Downregulation of FIP200 induces apoptosis of glioblastoma cells and microvascular endothelial cells by enhancing Pyk2 activity 2011
2011 Crystal structure of the TSH receptor (TSHR) bound to a blocking-type TSHR autoantibody 2011
2011 Hyperuricaemia, chronic kidney disease, and outcomes in heart failure: Potential mechanistic insights from epidemiological data 2011
2011 Immunoglobulin light chains activate nuclear factor-κB in renal epithelial cells through a Src-dependent mechanism 2011
2011 Activation of corticotropin-releasing factor receptor 2 mediates the colonic motor coping response to acute stress in rodents 2011
2011 Light chain-mediated tubulopathies 2011
2011 Mechanisms and consequences of salt sensitivity and dietary salt intake 2011
2011 Paracrine effects of mesenchymal stem cells in cisplatin-induced renal injury require heme oxygenase-1 2011
2010 Mild hyperkalemia and outcomes in chronic heart failure: A propensity matched study 2010
2010 Monoclonal autoantibodies to the TSH receptor, one with stimulating activity and one with blocking activity, obtained from the same blood sample 2010
2010 Association between hyperuricemia and incident heart failure among older adults: A propensity-matched study 2010
2010 Immunoglobulin light chains activate tubular epithelial cells through redox signaling 2010
2010 Hypokalemia and outcomes in patients with chronic heart failure and chronic kidney disease findings from propensity-matched studies 2010
2009 Potassium inhibits dietary salt-induced transforming growth factor-β production 2009
2009 Vascular consequences of dietary salt intake 2009
2009 Dietary salt intake, salt sensitivity, and cardiovascular health 2009
2009 Isolated systolic hypertension and incident heart failure in older adults: A propensity-matched study 2009
2009 Association of chronic kidney disease with outcomes in chronic heart failure: A propensity-matched study 2009
2009 Bortezomib successfully reduces monoclonal serum free light chain levels in a patient with recurrent myeloma and cast nephropathy in the renal transplant. 2009
2008 Dietary salt activates an endothelial proline-rich tyrosine kinase 2/c-Src/phosphatidylinositol 3-kinase complex to promote endothelial nitric oxide synthase phosphorylation 2008
2008 Mechanism of dietary salt-mediated increase in intravascular production of TGF-β1 2008
2008 A human monoclonal autoantibody to the thyrotropin receptor with thyroid-stimulating blocking activity 2008
2008 Contribution of intrarenal cells to cellular repair after acute kidney injury: Subcapsular implantation technique 2008
2008 Salt sensitivity: It is not always in the genes 2008
2007 Detection of early changes in renal function using 99mTc-MAG3 imaging in a murine model of ischemia-reperfusion injury 2007
2007 Assessment and treatment of hypertension in dialysis: The case for salt restriction 2007
2007 Molecular interactions between the TSH receptor and a thyroid-stimulating monoclonal autoantibody 2007
2007 Crystal structure of the TSH receptor in complex with a thyroid-stimulating autoantibody 2007
2007 Immunoglobulin light chains generate hydrogen peroxide 2007
2007 Chronic Kidney Disease Associated Mortality in Diastolic Versus Systolic Heart Failure: A Propensity Matched Study†The Digitalis Investigation Group study was conducted and supported by the National Heart, Lung, and Blood Institute in collaboration with the Digitalis Investigation Group Investigators ... 2007
2007 EGF receptor activity modulates apoptosis induced by inhibition of the proteasome of vascular smooth muscle cells 2007
2006 Effects of TSH receptor mutations on binding and biological activity of monoclonal antibodies and TSH 2006
2006 Uric acid: An old dog with new tricks? 2006
2006 A new twist in myeloma treatment 2006
2006 Effect of salt intake on progression of chronic kidney disease 2006
2005 Enhanced expression of EGF receptor in a model of salt-sensitive hypertension 2005
2005 Management of paraproteinemic renal disease 2005
2005 Mechanism of hypertensive nephropathy in the Dahl/Rapp rat: A primary disorder of vascular smooth muscle 2005
2004 AL-amyloidosis is underdiagnosed in renal biopsies 2004
2004 Salt Intake, Endothelial Cell Signaling, and Progression of Kidney Disease 2004
2003 Accelerated ubiquitination and proteasome degradation of a genetic variant of inducible nitric oxide synthase 2003
2003 The interrelationship between TGF-beta1 and nitric oxide is altered in salt-sensitive hypertension. 2003
2003 The interrelationship between TGF-β1 and nitric oxide is altered in salt-sensitive hypertension 2003
2003 Mitochondrial targets of oxidative stress during renal ischemia/reperfusion 2003
2002 Increased dietary salt activates rat aortic endothelium 2002
2002 Increased dietary salt activates rat aortic endothelium. 2002
2002 Activation of the Fas/Fas ligand pathway in hypertensive renal disease in Dahl/Rapp rats 2002
2002 Dietary salt intake activates MAP kinases in the rat kidney. 2002
2001 Mitochondrial tyrosine nitration precedes chronic allograft nephropathy 2001
2001 Nitric oxide synthase (NOS2) mutation in Dahl/Rapp rats decreases enzyme stability 2001
2001 Cytochrome c mediates apoptosis in hypertensive nephrosclerosis in Dahl/Rapp rats 2001
2001 Increased dietary salt accelerates chronic allograft nephropathy in rats 2001
2001 Mapping the binding domain of immunoglobulin light chains for Tamm-Horsfall protein 2001
2001 The distribution and regulation of integrin-linked kinase in normal and diabetic kidneys 2001
2000 Induction of apoptosis during development of hypertensive nephrosclerosis 2000
1999 Dietary salt increases endothelial nitric oxide synthase and TGF-beta1 in rat aortic endothelium. 1999
1999 Dietary salt increases endothelial nitric oxide synthase and TGF-β1 in rat aortic endothelium 1999
1999 Glomerulopathic light chain-mesangial cell interactions modulate in vitro extracellular matrix remodeling and reproduce mesangiopathic findings documented in vivo 1999
1998 Crossover comparison of intravenous and subcutaneous recombinant human erythropoietin in a small haemodialysis unit [6] 1998
1998 Dietary salt enhances glomerular endothelial nitric oxide synthase through TGF-beta1. 1998
1998 Dietary salt enhances glomerular endothelial nitric oxide synthase through TGF-β1 1998
1998 Inverse relationship of urinary cyclic GMP to blood pressure reactivity in the CARDIA study: vasodilatory regulation of sympathetic vasoconstriction. Coronary Artery Risk Development in Young Adults. 1998
1998 Dietary salt modulates renal production of transforming growth factor-beta in rats. 1998
1998 Dietary salt modulates renal production of transforming growth factor-β in rats 1998
1998 Concordant genetic and physiological data are required for candidate genes (multiple letters) 1998
1998 Dietary salt regulates expression of Tamm-Horsfall glycoprotein in rats 1998
1998 In vitro modulation of AL-amyloid formation by Human Mesangial Cells exposed to amyloidogenic Light Chains 1998
1998 Inverse relationship of urinary cyclic GMP to blood pressure reactivity in the CARDIA study: Vasodilatory regulation of sympathetic vasoconstriction 1998
1998 Studies of arginine metabolism and salt sensitivity in the Dahl/Rapp rat models of hypertension 1998
1998 Vascular smooth muscle nitric oxide synthase anomalies in Dahl/Rapp salt-sensitive rats 1998
1997 Relationship of diastolic blood pressure with cyclic GMP excretion among young adults (the CARDIA study): Influence of a family history of hypertension 1997
1997 Estrogen restores endothelial cell function in an experimental model of vascular injury 1997
1997 Relationship of diastolic blood pressure with cyclic GMP excretion among young adults (the CARDIA Study): influence of a family history of hypertension. Coronary Artery Risk Development in Young Adults. 1997
1997 Integrated expression of glomerular extracellular matrix proteins and β1 integrins in monoclonal light chain-related renal diseases 1997
1997 Immunoglobulin light chain alters mesangial cell calcium homeostasis 1997
1997 Immunoglobulin light chain alters mesangial cell calcium homeostasis. 1997
1997 Localization of a single binding site for immunoglobulin light chains on human Tamm-Horsfall glycoprotein 1997
1996 In vitro AL-ahyloid formation is associated with low TGF-B activity 1996
1996 Calciphylaxis mimicking skin lesions of connective tissue diseases 1996
1996 In vitro AL-amyloid formation by rat and human mesangial cells 1996
1996 Salt-sensitive hypertension: Lessons from animal models 1996
1996 Structural analysis of the light chain binding site on tamm-horsfall glycoprotein 1996
1995 Biochemical interaction between Tamm-Horsfall glycoprotein and Ig light chains in the pathogenesis of cast nephropathy 1995
1995 Cyclosporine inhibits the renal response to L-arginine in human kidney transplant recipients 1995
1995 L-arginine and arginine analogs in progressive penal failure 1995
1995 Pathogenesis of glomerulosclerosis in light chain deposition disease: Role for transforming growth factor-β 1995
1994 Adaptive control of anticoagulation during hemodialysis 1994
1994 Growth factors in monoclonal light-chain-related renal diseases 1994
1994 Pathogenesis and treatment of myeloma kidney 1994
1994 Ultrastructural immunolabeling: A unique diagnostic tool in monoclonal light chain-related renal diseases 1994
1993 Myeloma kidney 1993
1993 Bence Jones proteins bind to a common peptide segment of Tamm-Horsfall glycoprotein to promote heterotypic aggregation 1993
1993 Hypertensive nephrosclerosis in the Dahl/Rapp rat: Initial sites of injury and effect of dietary L-arginine supplementation 1993
1993 Monoclonal immunoglobulin light chain-related renal diseases 1993
1993 Potential role of colchicine in the prevention of cast nephropathy from Bence Jones proteins. 1993
1993 Renal involvement in plasma cell dyscrasias. 1993
1993 Role of nitric oxide synthesis in salt-sensitive hypertension in Dahl/Rapp rats 1993
1992 Role of nitric oxide in regulation of blood pressure 1992
1992 Pathobiology of cast nephropathy from human Bence Jones proteins 1992
1991 Spectrum of glomerular and tubulointerstitial renal lesions associated with monotypical immunoglobulin light chain deposition 1991
1991 L-arginine abrogates salt-sensitive hypertension in Dahl/Rapp rats 1991
1990 Altered loop segment function is the initial event in precipitation of low-molecular-weight proteins in the rat nephron. 1990
1990 Mechanisms of intranephronal proteinaceous cast formation by low molecular weight proteins 1990
1989 Ultrastructural immunogold labeling patterns--image processing, mapping and quantitative microanalysis of antigenic sites in renal biopsies and neoplasms. 1989
1988 Differential nephrotoxicity of low molecular weight proteins including Bence Jones proteins in the perfused rat nephron in vivo 1988
1988 Differential toxicity of human Bence-Jones proteins in the rat proximal convoluted tubule in vivo. 1988
1988 Morphologic alterations of the proximal tubules in light chain-related renal disease 1988
1987 Acute renal failure without fibrotic skin changes in progressive systemic sclerosis 1987
1987 Human Bence Jones protein toxicity in rat proximal tubule epithelium in vivo 1987
1986 Human complement protein D catabolism by the rat kidney 1986
1985 Effect of urinary pH and diatrizoate on Bence Jones protein nephrotoxicity in the rat 1985
1985 Hemodialysis Without Anticoagulation 1985
1984 Volume-independent reductions in glomerular filtration rate in acute chloride-depletion alkalosis in the rat. Evidence for mediation by tubuloglomerular feedback 1984
1978 The antiarrhythmic action of amitriptyline on arrhythmias associated with myocardial infarction in dogs 1978
1978 Beneficial effects of amitriptyline (AMI) in experimental arrhythmias in the dog 1978

Book

Year Title Altmetric
2007 Paraproteinemic renal diseases that involve the tubulo-interstitium.  Ed. 153.  2007

Chapter

Year Title Altmetric
2013 Dysproteinemias and amyloidosis.  235-243. 2013
2008 Myeloma and Secondary Involvement of the Kidney in Dysproteinemias.  461-468. 2008
2008 Pathogenesis of paraproteinemic renal disease.  435-440. 2008
2007 The influence of dietary salt intake on endothelial cell function.  1287-1293. 2007

Investigator On

  • Center for Clinical and Translational Science (3 Linked Awards UL1, KL2, TL1)  awarded by National Center for Advancing Translational Sciences/NIH/DHHS 2019 - 2024
  • Interdisciplinary Training In Kidney Related Research  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2019 - 2024
  • UAB-UCSD O'Brien Center for Acute Kidney Injury Research  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2018 - 2023
  • UAB-UCSD O'Brien Center for Acute Kidney Injury Research - Admin Core  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2018 - 2023
  • UAB Center for Clinical and Translational Science (CCTS) (3 Linked Awards UL1, KL2, TL1)  awarded by National Center for Advancing Translational Sciences/NIH/DHHS 2015 - 2019
  • Ferritin Mediates Epithelial Cell-Macrophage Cross Talk in Acute Kidney Injury  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2014 - 2019
  • Interdisciplinary Training in Kidney-Related Research  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2014 - 2019
  • UAB/UCSD O'Brien Core Center for Acute Kidney Injury Research  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2013 - 2018
  • UAB/UCSD O'Brien Core Center for Acute Kidney Injury Research - Administrative Core  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2013 - 2018
  • The Endoplasmic Reticulum Stress Protein Calreticulin in Diabetic Chronic Kidney Disease  awarded by DOD - ARMY MEDICAL RESEARCH ACQUISITION ACTIVITY 2014 - 2017
  • Training Program in Cardiovascular Pathophysiology  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2014 - 2015
  • UAB-UCSD O'Brien Core Center for Acute Kidney Injury Research  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2008 - 2014
  • UAB-UCSD O'Brien Core Center for Acute Kidney Injury Research - Administrative Core  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2008 - 2014
  • Education And Training

  • UAB Hospital, Internship 1980
  • UAB Hospital, Residency 1982
  • UAB Hospital, Postdoctoral Fellowship 1985
  • Full Name

  • Paul Sanders