Positions

Overview

  • Dr. Krishnamurthy completed his Bachelors in Veterinary Medicine from Bangalore Veterinary College and earned his Ph.D. in Veterinary Pathology from the Indian Veterinary Research Institute, India. He held faculty appointments at the Feinberg Cardiovascular Research Institute, School of Medicine at Northwestern University in Chicago, Illinois and Houston Methodist Research Institute before joining UAB. Dr.Krishnamurthy directs a research program focusing on understanding mechanisms of cardiovascular diseases and developing novel therapeutic strategies to promote cardiac regeneration and repair. Dr. Krishnamurthy’s laboratory is supported through funds from National Institutes of Health (NIH-R01) and American Heart Association (GIA and Postdoctoral).

    • Selected Publications

    Academic Article

    Year Title Altmetric
    2022 Inhibition of RUNX1 blocks the differentiation of lung fibroblasts to myofibroblasts.  Journal of Cellular Physiology.  237:2169-2182. 2022
    2022 MicroRNA-181c-5p modulates phagocytosis efficiency in bone marrow-derived macrophages.  Inflammation Research.  71:321-330. 2022
    2022 Increased m6A-RNA methylation and FTO suppression is associated with myocardial inflammation and dysfunction during endotoxemia in mice.  Molecular and Cellular Biochemistry: an international journal for chemical biology in health and disease.  477:129-141. 2022
    2021 Phosphatidylinositol-4,5-Bisphosphate Binding to Amphiphysin-II Modulates T-Tubule Remodeling: Implications for Heart Failure.  Frontiers in Physiology.  12. 2021
    2021 Novel Mechanisms of Exosome-Mediated Phagocytosis of Dead Cells in Injured Heart.  Circulation Research.  129:1006-1020. 2021
    2021 Cardiac glycosaminoglycans and structural alterations during chronic stress-induced depression-like behavior in mice.  American Journal of Physiology: Heart and Circulatory Physiology.  320:H2044-H2057. 2021
    2021 Mechanisms of COVID-19-induced cardiovascular disease: Is sepsis or exosome the missing link?.  Journal of Cellular Physiology.  236:3366-3382. 2021
    2021 Myofibroblast-Derived Exosome Induce Cardiac Endothelial Cell Dysfunction..  Frontiers in Cardiovascular Medicine.  8:676267. 2021
    2021 Transcriptional Regulation of Structural and Functional Adaptations in a Developing Adulthood Myocardium. 2021
    2021 microRNA-377 Signaling Modulates Anticancer Drug-Induced Cardiotoxicity in Mice..  Frontiers in Cardiovascular Medicine.  8:737826. 2021
    2020 Exosomes secreted by hiPSC-derived cardiac cells improve recovery from myocardial infarction in swine.  Science Translational Medicine.  12. 2020
    2020 IL-10 provides cardioprotection in diabetic myocardial infarction via upregulation of Heme clearance pathways.  JCI insight.  5. 2020
    2020 Nano-Vesicle (Mis)Communication in Senescence-Related Pathologies.  Cells.  9. 2020
    2020 Myocardial protection by nanomaterials formulated with CHIR99021 and FGF1.  JCI insight.  5. 2020
    2020 DNA damage-free iPS cells exhibit potential to yield competent cardiomyocytes.  American Journal of Physiology: Heart and Circulatory Physiology.  318:H801-H815. 2020
    2020 Targeting exosome-associated human antigen R attenuates fibrosis and inflammation in diabetic heart.  The FASEB Journal.  34:2238-2251. 2020
    2020 Cardiovascular Changes Associated with Hypertensive Heart Disease and Aging.  Cell Transplantation.  29. 2020
    2019 The Art of Intercellular Wireless Communications: Exosomes in Heart Disease and Therapy.  Frontiers in Cell and Developmental Biology.  7. 2019
    2019 Cardiomyocytes from CCND2-overexpressing human induced-pluripotent stem cells repopulate the myocardial scar in mice: A 6-month study.  Journal of Molecular and Cellular Cardiology.  137:25-33. 2019
    2019 Sam68 impedes the recovery of arterial injury by augmenting inflammatory response.  Journal of Molecular and Cellular Cardiology.  137:82-92. 2019
    2019 OBG-like ATPase 1 inhibition attenuates angiotensin II-induced hypertrophic response in human ventricular myocytes via GSK-3beta/beta-catenin signalling.  Clinical and Experimental Pharmacology and Physiology.  46:743-751. 2019
    2019 Exercise Mediated Nrf2 Signaling Protects the Myocardium From Isoproterenol-Induced Pathological Remodeling.  Frontiers in Cardiovascular Medicine.  6. 2019
    2019 Convergences of Life Sciences and Engineering in Understanding and Treating Heart Failure.  Circulation Research.  124:161-169. 2019
    2017 Interleukin-10 inhibits bone marrow fibroblast progenitor cell-mediated cardiac fibrosis in pressure-overloaded myocardium.  Circulation.  136:940-953. 2017
    2017 Therapeutic inhibition of miR-375 attenuates post-myocardial infarction inflammatory response and left ventricular dysfunction via PDK-1-AKT signalling axis.  Cardiovascular Research.  113:938-949. 2017
    2017 Assessment of MiRNA regulation of endothelial progenitor cell mediated angiogenesis.  Methods in Molecular Biology.  1553:305-314. 2017
    2016 MicroRNA-126 overexpression rescues diabetes-induced impairment in efferocytosis of apoptotic cardiomyocytes.  Scientific Reports.  6. 2016
    2016 Editorial Commentary: miRNA a tiny genetic tool: Key to the puzzle of cardiovascular disease.  Trends in Cardiovascular Medicine.  26:420-422. 2016
    2016 Role of MAPK-mediated endoplasmic reticulum stress signaling in the heart during aging in senescence-accelerated prone mice.  BioFactors.  42:368-375. 2016
    2016 Naringenin ameliorates skin inflammation and accelerates phenotypic reprogramming from M1 to M2 macrophage polarization in atopic dermatitis NC/Nga mouse model.  Experimental Dermatology.  25:404-407. 2016
    2016 Alcohol Toxicity in Diabetes and Its Complications: A Double Trouble?.  Alcoholism: Clinical and Experimental Research.  40:686-697. 2016
    2016 Angiotensin receptor blockers: Focus on cardiac and renal injury.  Trends in Cardiovascular Medicine.  26:221-228. 2016
    2016 Modulation of Macrophage Polarization and HMGB1-TLR2/TLR4 Cascade Plays a Crucial Role for Cardiac Remodeling in Senescence-Accelerated Prone Mice.  PLoS One.  11. 2016
    2016 MicroRNA-9 inhibits hyperglycemia-induced pyroptosis in human ventricular cardiomyocytes by targeting ELAVL1.  Biochemical and Biophysical Research Communications.  471:423-429. 2016
    2016 Depletion of cardiac 14-3-3η protein adversely influences pathologic cardiac remodeling during myocardial infarction after coronary artery ligation in mice.  International Journal of Cardiology.  202:146-153. 2016
    2016 IL-10 accelerates re-endothelialization and inhibits post-injury intimal hyperplasia following carotid artery denudation.  PLoS One.  11. 2016
    2015 Interleukin-10 inhibits chronic angiotensin II-induced pathological autophagy.  Journal of Molecular and Cellular Cardiology.  89:203-213. 2015
    2015 Negative Regulation of miR-375 by Interleukin-10 Enhances Bone Marrow-Derived Progenitor Cell-Mediated Myocardial Repair and Function after Myocardial Infarction.  Stem Cells.  33:3519-3529. 2015
    2015 Enhanced cardiac regenerative ability of stem cells after ischemia-reperfusion injury: Role of human CD34+ cells deficient in microRNA-377.  Journal of the American College of Cardiology.  66:2214-2226. 2015
    2015 Schisandrin B ameliorates ICV-infused amyloid β induced oxidative stress and neuronal dysfunction through inhibiting RAGE/NF-κB/MAPK and Up-regulating HSP/beclin expression.  PLoS One.  10. 2015
    2015 RNA-stabilizing proteins as molecular targets in cardiovascular pathologies.  Trends in Cardiovascular Medicine.  25:676-683. 2015
    2015 Enhancer-associated long noncoding RNAs: A novel frontier with new perception in cardiac regeneration.  Trends in Cardiovascular Medicine.  25:603-605. 2015
    2015 Sirtuin-6 deficiency exacerbates diabetes-induced impairment of wound healing.  Experimental Dermatology.  24:773-778. 2015
    2015 Embryonic Stem Cell-Derived Exosomes Promote Endogenous Repair Mechanisms and Enhance Cardiac Function Following Myocardial Infarction.  Circulation Research.  117:52-64. 2015
    2015 Schisandrin b prevents doxorubicin induced cardiac dysfunction by modulation of DNA damage, oxidative stress and inflammation through inhibition of mapk/p53 signaling.  PLoS One.  10. 2015
    2014 Small engine, big power: MicrorNAS as regulators of cardiac diseases and regeneration.  International Journal of Molecular Sciences.  15:15891-15911. 2014
    2013 Alcohol consumption negates estrogen-mediated myocardial repair in ovariectomized mice by inhibiting endothelial progenitor cell mobilization and function.  Journal of Biological Chemistry.  288:18022-18034. 2013
    2013 Bone Marrow Progenitor Cell Therapy-Mediated Paracrine Regulation of Cardiac miRNA-155 Modulates Fibrotic Response in Diabetic Hearts.  PLoS One.  8. 2013
    2012 Histone deacetylase 1 deficiency impairs differentiation and electrophysiological properties of cardiomyocytes derived from induced pluripotent cells.  Stem Cells.  30:2412-2422. 2012
    2012 Elucidation of a Novel Pathway through Which HDAC1 Controls Cardiomyocyte Differentiation through Expression of SOX-17 and BMP2.  PLoS One.  7. 2012
    2012 Interleukin-10 treatment attenuates pressure overload-induced hypertrophic remodeling and improves heart function via signal transducers and activators of transcription 3-dependent inhibition of nuclear factor-κB.  Circulation.  126:418-429. 2012
    2012 Enhanced angiogenic and cardiomyocyte differentiation capacity of epigenetically reprogrammed mouse and human endothelial progenitor cells augments their efficacy for ischemic myocardial repair.  Circulation Research.  111:180-190. 2012
    2011 Interleukin-10 deficiency impairs bone marrow-derived endothelial progenitor cell survival and function in ischemic myocardium.  Circulation Research.  109:1280-1289. 2011
    2010 Myocardial knockdown of mRNA-stabilizing protein HuR attenuates post-MI inflammatory response and left ventricular dysfunction in IL-10-null mice.  The FASEB Journal.  24:2484-2494. 2010
    2010 Career moves: Induced pluripotent cells from human aortic smooth muscle cells can efficiently redifferentiate into parental phenotype.  Circulation Research.  106:7-9. 2010
    2009 IL-10 inhibits inflammation and attenuates left ventricular remodeling after myocardial infarction via activation of STAT3 and suppression of HuR.  Circulation Research.  104. 2009
    2009 Inhibition of matrix metalloproteinases improves left ventricular function in mice lacking osteopontin after myocardial infarction.  Molecular and Cellular Biochemistry: an international journal for chemical biology in health and disease.  322:53-62. 2009
    2008 Cell-free embryonic stem cell extract-mediated derivation of multipotent stem cells from NIH3T3 fibroblasts for functional and anatomical ischemic tissue repair.  Circulation Research.  102. 2008
    2007 β1 integrins modulate β-adrenergic receptor-stimulated cardiac myocyte apoptosis and myocardial remodeling.  Hypertension.  49:865-872. 2007
    2007 Lack of osteopontin improves cardiac function in streptozotocin-induced diabetic mice.  American Journal of Physiology: Heart and Circulatory Physiology.  292. 2007
    2006 Behavioural and neurotoxic effects in Wistar rats induced by low doses of ochratoxin A.  Toxicology International.  13:93-98. 2006
    2006 Expression of the cytoplasmic domain of β1 integrin induces apoptosis in adult rat ventricular myocytes (ARVM) via the involvement of caspase-8 and mitochondrial death pathway.  Basic Research in Cardiology.  101:485-493. 2006
    2006 Deficiency of β1 integrins results in increased myocardial dysfunction after myocardial infarction.  Heart.  92:1309-1315. 2006
    2005 Pathogenicity of Pasteurella multocida A:1 in experimentally infected chickens and chicken embryos.  Indian Journal of Animal Sciences.  75:411-414. 2005
    2003 Correlation of clinicopathological and microbiological studies in experimental fowl typhoid and pullorum disease in chicken.  Indian Journal of Animal Sciences.  73:627-629. 2003
    2002 Immunocytochemical detection of Salmonella Gallinarum and Salmonella Pullorum in experimentally infected chickens.  Indian Journal of Animal Sciences.  72:113-116. 2002

    Chapter

    Year Title Altmetric
    2020 S100 family proteins in inflammation and beyond 2020
    2017 Kampo Medicine for Hypertension and Related Disorders.  59-67. 2017
    2017 Significance of Japanese Kampo Medicine in Supportive Care of Heart Failure/Function.  47-57. 2017

    Education And Training

  • Doctor of Philosophy Level Degree in Veterinary Pathology Residency Program, Indian Veterinary Research Institute 2003
  • Master of Science in Veterinary Pathology Residency Program, Indian Veterinary Research Institute 2000
  • Bachelor of Science or Mathematics in Veterinary Medicine, University of Agricultural Sciences/Bangalore 1998

    • Full Name

  • Prasanna Krishnamurthy