Positions

Overview

  • Dr. Krishnamurthy completed his Bachelors in Veterinary Medicine from Bangalore Veterinary College and earned his Ph.D. in Veterinary Pathology from the Indian Veterinary Research Institute, India. He held faculty appointments at the Feinberg Cardiovascular Research Institute, School of Medicine at Northwestern University in Chicago, Illinois and Houston Methodist Research Institute before joining UAB. Dr.Krishnamurthy directs a research program focusing on understanding mechanisms of cardiovascular diseases and developing novel therapeutic strategies to promote cardiac regeneration and repair. Dr. Krishnamurthy’s laboratory is supported through funds from National Institutes of Health (NIH-R01) and American Heart Association (GIA and Postdoctoral).

    • Selected Publications

    Academic Article

    Year Title Altmetric
    2021 Cardiac glycosaminoglycans and structural alterations during chronic stress-induced depression-like behavior in mice 2021
    2020 Nano-Vesicle (Mis)Communication in Senescence-Related Pathologies.  Cells.  9. 2020
    2020 DNA damage-free iPS cells exhibit potential to yield competent cardiomyocytes 2020
    2020 Cardiovascular Changes Associated with Hypertensive Heart Disease and Aging.  Cell Transplantation.  29. 2020
    2019 OBG-like ATPase 1 inhibition attenuates angiotensin II-induced hypertrophic response in human ventricular myocytes via GSK-3beta/beta-catenin signalling.  Clinical and Experimental Pharmacology and Physiology.  46:743-751. 2019
    2019 Convergences of Life Sciences and Engineering in Understanding and Treating Heart Failure.  Circulation Research.  124:161-169. 2019
    2017 Interleukin-10 inhibits bone marrow fibroblast progenitor cell-mediated cardiac fibrosis in pressure-overloaded myocardium.  Circulation.  136:940-953. 2017
    2017 Therapeutic inhibition of miR-375 attenuates post-myocardial infarction inflammatory response and left ventricular dysfunction via PDK-1-AKT signalling axis.  Cardiovascular Research.  113:938-949. 2017
    2016 Role of MAPK-mediated endoplasmic reticulum stress signaling in the heart during aging in senescence-accelerated prone mice.  BioFactors.  42:368-375. 2016
    2016 Naringenin ameliorates skin inflammation and accelerates phenotypic reprogramming from M1 to M2 macrophage polarization in atopic dermatitis NC/Nga mouse model.  Experimental Dermatology.  25:404-407. 2016
    2016 Alcohol Toxicity in Diabetes and Its Complications: A Double Trouble?.  Alcoholism: Clinical and Experimental Research.  40:686-697. 2016
    2016 MicroRNA-9 inhibits hyperglycemia-induced pyroptosis in human ventricular cardiomyocytes by targeting ELAVL1.  Biochemical and Biophysical Research Communications.  471:423-429. 2016
    2015 Sirtuin-6 deficiency exacerbates diabetes-induced impairment of wound healing.  Experimental Dermatology.  24:773-778. 2015
    2015 Embryonic Stem Cell-Derived Exosomes Promote Endogenous Repair Mechanisms and Enhance Cardiac Function Following Myocardial Infarction.  Circulation Research.  117:52-64. 2015
    2012 Interleukin-10 treatment attenuates pressure overload-induced hypertrophic remodeling and improves heart function via signal transducers and activators of transcription 3-dependent inhibition of nuclear factor-κB.  Circulation.  126:418-429. 2012
    2012 Enhanced angiogenic and cardiomyocyte differentiation capacity of epigenetically reprogrammed mouse and human endothelial progenitor cells augments their efficacy for ischemic myocardial repair.  Circulation Research.  111:180-190. 2012
    2011 Interleukin-10 deficiency impairs bone marrow-derived endothelial progenitor cell survival and function in ischemic myocardium.  Circulation Research.  109:1280-1289. 2011
    2010 Career moves: Induced pluripotent cells from human aortic smooth muscle cells can efficiently redifferentiate into parental phenotype.  Circulation Research.  106:7-9. 2010
    2009 IL-10 inhibits inflammation and attenuates left ventricular remodeling after myocardial infarction via activation of STAT3 and suppression of HuR.  Circulation Research.  104. 2009
    2008 Cell-free embryonic stem cell extract-mediated derivation of multipotent stem cells from NIH3T3 fibroblasts for functional and anatomical ischemic tissue repair.  Circulation Research.  102. 2008
    2007 Lack of osteopontin improves cardiac function in streptozotocin-induced diabetic mice 2007
    2006 Expression of the cytoplasmic domain of β1 integrin induces apoptosis in adult rat ventricular myocytes (ARVM) via the involvement of caspase-8 and mitochondrial death pathway.  Basic Research in Cardiology.  101:485-493. 2006

    Chapter

    Year Title Altmetric
    2020 S100 family proteins in inflammation and beyond 2020
    2017 Kampo Medicine for Hypertension and Related Disorders.  59-67. 2017
    2017 Significance of Japanese Kampo Medicine in Supportive Care of Heart Failure/Function.  47-57. 2017

    Education And Training

  • Doctor of Philosophy Level Degree in Veterinary Pathology Residency Program, Indian Veterinary Research Institute 2003
  • Master of Science in Veterinary Pathology Residency Program, Indian Veterinary Research Institute 2000
  • Bachelor of Science or Mathematics in Veterinary Medicine, University of Agricultural Sciences/Bangalore 1998

    • Full Name

  • Prasanna Krishnamurthy