Selected Publications

Academic Article

Year Title Altmetric
2018 The retinoid X receptor agonist, 9-cis UAB30, inhibits cutaneous T-cell lymphoma proliferation through the SKP2-p27kip1 axis.Journal of Dermatological Science.  90:343-356. 2018
2015 Osteopontin mediates tumorigenic transformation of a preneoplastic murine cell line by suppressing anoikis: an Arg-Gly-Asp-dependent-focal adhesion kinase-caspase-8 axis.Molecular Carcinogenesis.  54:379-392. 2015
2015 Osteopontin mediates tumorigenic transformation of a preneoplastic murine cell line by suppressing anoikis: An Arg-Gly-Asp-dependent-focal adhesion kinase-caspase-8 axisMolecular Carcinogenesis.  54:379-392. 2015
2014 Osteopontin facilitates ultraviolet B-induced squamous cell carcinoma development.Journal of Dermatological Science.  75:121-132. 2014
2012 Host-derived osteopontin maintains an acute inflammatory response to suppress early progression of extrinsic cancer cells.International Journal of Cancer.  131:322-333. 2012
2011 Reduced mitogenicity of sera following weight loss in premenopausal women.Nutrition and Cancer.  63:916-923. 2011
2010 Establishment and characterization of an osteopontin-null cutaneous squamous cell carcinoma cell line.In Vitro Cellular and Developmental Biology - Animal.  46:87-91. 2010
2008 Osteopontin expression in normal skin and non-melanoma skin tumors.Journal of Histochemistry and Cytochemistry.  56:57-66. 2008
2006 Papilloma development is delayed in osteopontin-null mice: implicating an antiapoptosis role for osteopontin.Cancer Research.  66:7119-7127. 2006
2006 Comparison of fetal and adult marrow stromal cells in osteogenesis with and without glucocorticoids.Connective Tissue Research.  47:67-76. 2006
2006 Production of chemokine CXCL1/KC by okadaic acid through the nuclear factor-kappaB pathway.Carcinogenesis.  27:43-52. 2006
2005 Erratum: Primary human marrow stromal cells and Saos-2 osteosarcoma cells use different mechanisms to adhere to hydroxylapatite (Journal of Biomedical Materials Research - Part A (2004) 68A, 2 (273-285) DOI: 10.1002/jbm.a.20043)Journal of Biomedical Materials Research.  73:254. 2005
2004 Primary human marrow stromal cells and Saos-2 osteosarcoma cells use different mechanisms to adhere to hydroxylapatite.Journal of Biomedical Materials Research Part A.  68:273-285. 2004
2003 Differential expression of mammalian or viral promoter-driven gene in adherent versus suspension cells.In Vitro Cellular and Developmental Biology - Animal.  39:420-423. 2003
2003 Osteopontin induction is required for tumor promoter-induced transformation of preneoplastic mouse cells.Carcinogenesis.  24:1749-1758. 2003
2002 Promotion of malignant astrocytoma cell migration by osteopontin expressed in the normal brain: differences in integrin signaling during cell adhesion to osteopontin versus vitronectin.Cancer Research.  62:5336-5343. 2002
2002 Novel protein kinase C isoforms and mitogen-activated kinase kinase mediate phorbol ester-induced osteopontin expression.The International journal of biochemistry.  34:1142-1151. 2002
2001 Hydroxylapatite binds more serum proteins, purified integrins, and osteoblast precursor cells than titanium or steel.Journal of Biomedical Materials Research.  57:258-267. 2001
2001 Omega-3 fatty acids decrease protein kinase expression in human breast cancer cells.Breast Cancer Research and Treatment.  67:279-283. 2001
2000 Expression of osteopontin messenger RNA and protein in rheumatoid arthritis: effects of osteopontin on the release of collagenase 1 from articular chondrocytes and synovial fibroblasts.Arthritis and Rheumatism.  43:1597-1605. 2000
2000 Attachment of primary neonatal rat astrocytes to vitronectin is mediated by integrins alphavbeta5 and alpha8beta1: modulation by the type 1 plasminogen activator inhibitor.Neuroscience Letters.  283:157-161. 2000
2000 Transforming JB6 cells exhibit enhanced integrin-mediated adhesion to osteopontin.Journal of Cellular Biochemistry.  78:8-23. 2000
1998 Osteopontin stimulates a subpopulation of quiescent human prostate epithelial cells with high proliferative potential to divide in vitro.Prostate.  35:83-94. 1998
1998 TPA-mediated regulation of osteopontin in human malignant glioma cellsAnticancer Research.  18:807-812. 1998
1998 TPA-mediated regulation of osteopontin in human malignant glioma cells.Anticancer Research.  18:807-812. 1998
1998 Cyclic GMP-dependent protein kinase inhibits osteopontin and thrombospondin production in rat aortic smooth muscle cells.Circulation Research.  82:139-146. 1998
1997 Phosphorylation of osteopontin by Golgi apparatus casein kinase.Biochemical and Biophysical Research Communications.  240:602-605. 1997
1997 Calcitriol enhancement of TPA-induced tumorigenic transformation is mediated through vitamin D receptor-dependent and -independent pathways.Clinical and Experimental Metastasis.  15:580-592. 1997
1997 Human osteosarcoma MG-63 cells plus or minus calcitriol treatment do not secrete osteopontinFederation proceedings.  11:3199-3199. 1997
1996 Effects of calcitriol and its analogs on osteopontin expression in rat osteosarcoma (ROS 17/2.8) and mouse osteoblast (MC3T3-E1) cellsFederation proceedings.  10. 1996
1996 Isolation of phosphorated and non-phosphorylated osteopontin by immobilized metal (Fe+ ) affinity chromatographyFederation proceedings.  10. 1996
1996 Osteopontin stimulates proliferation of a population of progenitors of prostate epithelial cells.Cell regulation.  7:1421-1421. 1996
1995 Effects of okadaic acid on calcitriol- and phorbol ester-induced expression and phosphorylation of osteopontin in mouse JB6 epidermal cells.Annals of the New York Academy of Sciences.  760:24-34. 1995
1994 Calcitriol regulation of osteopontin expression in mouse epidermal cells.Endocrinology.  135:863-869. 1994
1993 Calcium-binding properties of osteopontin derived from non-osteogenic sources.Journal of Biochemistry.  114:702-707. 1993
1993 1 alpha,25-Dihydroxyvitamin D3 enhances 12-O-tetradecanoylphorbol-13-acetate- induced tumorigenic transformation and osteopontin expression in mouse JB6 epidermal cells.Cancer Research.  53:2217-2220. 1993
1991 1 alpha,25-dihydroxyvitamin D3 stimulates synthesis and secretion of nonphosphorylated osteopontin (secreted phosphoprotein 1) in mouse JB6 epidermal cells.Cancer Research.  51:2144-2150. 1991

Research Overview

  • Project 1. Determining the function and regulation of matricellular protein, osteopontin, in normal and pathological conditions. Project 2. Assessing the therapeutic efficacy of novel RXR agonists in the treatment of cutaneous T-cell lymphoma (CTCL)
  • Education And Training

  • Bachelor of Arts in Natural Sciences, University of Chicago
  • Doctor of Philosophy in Nutrition Sciences, University of Alabama at Birmingham
  • Master of Life Sciences in Biochemistry, University of Chicago
  • Full Name

  • Pi-Ling Chang
  • Blazerid

  • plchang