Positions

Selected Publications

Academic Article

Year Title Altmetric
2017 GARP2 accelerates retinal degeneration in rod cGMP-gated cation channel β-subunit knockout miceScientific Reports.  7. 2017
2016 The B3 subunit of the cone cyclic nucleotide-gated channel regulates the light responses of cones and contributes to the channel structural flexibilityJournal of Biological Chemistry.  291:8721-8734. 2016
2016 Role of RDS and rhodopsin in Cngb1-related retinal degenerationInvestigative Ophthalmology & Visual Science.  57:787-797. 2016
2015 Varying the GARP2-to-RDS ratio leads to defects in rim formation and rod and cone functionInvestigative Ophthalmology & Visual Science.  56:8187-8198. 2015
2014 Overexpression of rod photoreceptor glutamic acid rich protein 2 (GARP2) increases gain and slows recovery in mouse retinaCell Communication and Signaling.  12. 2014
2013 Dynamic near-infrared imaging reveals transient phototropic change in retinal rod photoreceptorsJournal of Biomedical Optics.  18. 2013
2012 Three-dimensional architecture of the rod sensory cilium and its disruption in retinal neurodegenerationCell.  151:1029-1041. 2012
2012 Investigation of the hyper-reflective inner/outer segment band in optical coherence tomography of living frog retinaJournal of Biomedical Optics.  17. 2012
2012 Comparative intrinsic optical signal imaging of wild-type and mutant mouse retinasOptics Express.  20:7646-7654. 2012
2012 Age-related changes in Cngb1-X1 knockout mice: Prolonged cone survivalDocumenta Ophthalmologica.  124:163-175. 2012
2010 Activation of retinal guanylyl cyclase RetGC1 by GCAP1: Stoichiometry of binding and effect of new LCA-related mutationsBiochemistry.  49:709-717. 2010
2009 Knockout of GARPs and the β-subunit of the rod cGMP-gated channel disrupts disk morphogenesis and rod outer segment structural integrityJournal of Cell Science.  122:1192-1200. 2009
2009 Characterization of a canine model of autosomal recessive retinitis pigmentosa due to a PDE6A mutationInvestigative Ophthalmology & Visual Science.  50:801-813. 2009
2007 Focus on Molecules: Rod photoreceptor cGMP-gated cation channelExperimental Eye Research.  85:173-174. 2007
2007 Focus on Molecules: Rod cGMP Phosphodiesterase Type 6Experimental Eye Research.  84:1-2. 2007
2005 Identifying photoreceptors in blind eyes caused by RPE65 mutations: Prerequisite for human gene therapy successProceedings of the National Academy of Sciences.  102:6177-6182. 2005
2004 Characterization of 3′,5′ cyclic nucleotide phosphodiesterase activity in Y79 retinoblastoma cells: Absence of functional PDE6Molecular Vision.  10:738-749. 2004
2004 Functional analysis of the rod photoreceptor cGMP phosphodiesterase α-subunit gene promoter: Nrl and Crx are required for full transcriptional activityJournal of Biological Chemistry.  279:19800-19807. 2004
2002 Electroretinographic abnormalities in parents of patients with leber congenital amaurosis who have heterozygous GUCY2D mutationsArchives of Ophthalmology -New Series-.  120:1325-1330. 2002
2001 Reproducible high efficiency gene transfer into Y79 retinoblastoma cells using adenofectionJournal of Neuroscience Methods.  106:1-7. 2001
2001 A PDE6A promoter fragment directs transcription predominantly in the photoreceptorBiochemical and Biophysical Research Communications.  282:543-547. 2001
2001 Four novel mutations in the RPE65 gene in patients with Leber congenital amaurosis.Human Mutation.  18:164. 2001
2000 Rapid restoration of visual pigment and function with oral retinoid in a mouse model of childhood blindnessProceedings of the National Academy of Sciences.  97:8623-8628. 2000
2000 Genomic organization of the human rod photoreceptor cGMP-gated cation channel β-subunit geneGene.  245:311-318. 2000
1998 Structure and upstream region characterization of the human gene encoding rod photoreceptor cGMP phosphodiesterase α-subunitJournal of Molecular Neuroscience.  10:235-250. 1998
1997 Cloning and expression of the glucocorticoid receptor from the squirrel monkey (Saimiri boliviensis boliviensis), a glucocorticoid-resistant primateJournal of Clinical Endocrinology and Metabolism.  82:465-472. 1997
1997 Cloning and expression of the glucocorticoid receptor from the squirrel monkey (Saimiri boliviensis boliviensis), a glucocorticoid-resistant primate.Journal of Clinical Endocrinology and Metabolism.  82:465-472. 1997
1996 Retinal-specific guanylate cyclase gene mutations in Leber's congenital amaurosisNature Genetics.  14:461-464. 1996
1996 Cell-specific expression of the rat secretogranin II promoter.Endocrinology.  137:3815-3822. 1996
1996 Gene structure and chromosome localization to 7q21.3 of the human rod photoreceptor transducin γ-subunit gene (GNGT1)Genomics.  35:241-243. 1996
1996 The β subunit of human rod photoreceptor cGMP-gated cation channel is generated from a complex transcription unitFEBS Letters.  389:213-218. 1996
1996 Cell-specific expression of the rat secretogranin II promoterEndocrinology.  137:3815-3822. 1996
1995 In vivo requirement of protein prenylation for maintenance of retinal cytoarchitecture and photoreceptor structureJournal of Cell Biology.  130:431-439. 1995
1995 cDNA, gene structure, and chromosomal localization of human GAR1 (CNCG3L), a homolog of the third subunit of bovine photoreceptor cGMP-gated channelGenomics.  28:32-38. 1995
1995 Autosomal recessive retinitis pigmentosa caused by mutations in the α subunit of rod cGMP phosphodiesteraseNature Genetics.  11:468-471. 1995
1995 KEELER,CLYDE,EDGAR (1900-1994) - IN-MEMORIAMExperimental Eye Research.  60:3-4. 1995
1995 Lysosomal chitobiase (CTB) and the G-protein γ<inf>5</inf> subunit (GNG5) genes co-localize to human chromosome 1p22Cytogenetics and Cell Genetics.  71:44-46. 1995
1994 Sequence of rho Small GTP-Binding Protein cDNAs From Human Retina and Identification of Novel 5′ End Cloning ArtifactsExperimental Eye Research.  59:235-237. 1994
1994 A yac contig of approximately 3 mb from human chromosome 5q31 → q33Genomics.  19:470-477. 1994
1994 Human retinal guanylate cyclase (GUC2D) maps to chromosome 17p13.1Genomics.  22:478-481. 1994
1993 In vivo biosynthesis of cholesterol in the rat retinaFEBS Letters.  335:234-238. 1993
1993 PCR analysis of DNA from 70-year-old sections of rodless retina demonstrates identity with the mouse rd defectProceedings of the National Academy of Sciences.  90:9616-9619. 1993
1993 Irish setter dogs affected with rod/cone dysplasia contain a nonsense mutation in the rod cGMP phosphodiesterase β-subunit geneProceedings of the National Academy of Sciences.  90:3968-3972. 1993
1992 Primary structure of frog rhodopsinFEBS Letters.  313:103-108. 1992
1992 INVITRO ISOPRENYLATION AND MEMBRANE ASSOCIATION OF MOUSE ROD PHOTORECEPTOR CGMP PHOSPHODIESTERASE ALPHA-SUBUNIT AND BETA-SUBUNIT EXPRESSED IN BACTERIAJournal of Biological Chemistry.  267:8458-8463. 1992
1992 Primary structure and chromosomal localization of human and mouse rod photoreceptor cGMP-gated cation channelJournal of Biological Chemistry.  267:6257-6262. 1992
1992 Chromosome mapping of the rod photoreceptor cGMP phosphodiesterase β-subunit gene in mouse and human: Tight linkage to the Huntington disease region (4p16.3)Genomics.  12:750-754. 1992
1992 In vitro isoprenylation and membrane association of mouse rod photoreceptor cGMP phosphodiesterase α and β subunits expressed in bacteriaJournal of Biological Chemistry.  267:8458-8463. 1992
1992 Novel morphological changes in rat retina induced by intravitreal injection of lovastatinExperimental Eye Research.  54:149-152. 1992
1992 Syntenic assignments of visual transduction genes in cattleGenomics.  14:699-706. 1992
1991 Identification of a nonsense mutation in the rod photoreceptor cGMP phosphodiesterase β-subunit gene of the rd mouseProceedings of the National Academy of Sciences.  88:8322-8326. 1991
1991 Complete cDNA sequences of mouse rod photoreceptor cGMP phosphodiesterase α- and β-subunits, and identification of β′-, a putative β-subunit isozyme produced by alternative splicing of the β-subunit geneFEBS Letters.  278:107-114. 1991
1991 HSV antigens and HSV DNA in avascular and vascularized lesions of human herpes simplex keratitisCurrent Eye Research.  10:63-68. 1991
1991 The molecular genetics of retinal photoreceptor proteins involved in cGMP metabolism.Progress in clinical and biological research.  362:33-66. 1991
1990 Mouse opsin: Gene structure and molecular basis of multiple transcriptsJournal of Biological Chemistry.  265:20563-20569. 1990
1990 Molecular characterization of human and bovine rod photoreceptor cGMP phosphodiesterase α-subunit and chromosomal localization of the human geneGenomics.  6:272-283. 1990
1987 A new family of the poly-deoxyadenylated class of Drosophila transposable elements identified by a representative member at the dunce locusMolecular and General Genetics MGG.  208:325-328. 1987
1987 An interchromosomal gene conversion of the Drosophila dunce locus identified with restriction site polymorphisms: A potential involvement of transposable elements in gene conversionMolecular and General Genetics MGG.  208:315-324. 1987
1985 In vitro synthesis of rat brain hexokinaseBBA - General Subjects.  843:186-192. 1985

Education And Training

  • Doctor of Philosophy in Biochemistry, Michigan State University 1989
  • Full Name

  • Steven Pittler