Positions

Selected Publications

Academic Article

Year Title Altmetric
2017 GARP2 accelerates retinal degeneration in rod cGMP-gated cation channel β-subunit knockout mice.Scientific Reports.  7:42545. 2017
2016 The B3 Subunit of the Cone Cyclic Nucleotide-gated Channel Regulates the Light Responses of Cones and Contributes to the Channel Structural Flexibility.Journal of Biological Chemistry.  291:8721-8734. 2016
2016 Role of RDS and Rhodopsin in Cngb1-Related Retinal Degeneration.Investigative Ophthalmology & Visual Science.  57:787-797. 2016
2015 Varying the GARP2-to-RDS Ratio Leads to Defects in Rim Formation and Rod and Cone Function.Investigative Ophthalmology & Visual Science.  56:8187-8198. 2015
2014 Overexpression of rod photoreceptor glutamic acid rich protein 2 (GARP2) increases gain and slows recovery in mouse retina.Cell Communication and Signaling.  12:67. 2014
2013 Dynamic near-infrared imaging reveals transient phototropic change in retinal rod photoreceptors.Journal of Biomedical Optics.  18:106013. 2013
2012 Three-dimensional architecture of the rod sensory cilium and its disruption in retinal neurodegeneration.Cell.  151:1029-1041. 2012
2012 Age-related changes in Cngb1-X1 knockout mice: prolonged cone survival.Documenta Ophthalmologica.  124:163-175. 2012
2012 Investigation of the hyper-reflective inner/outer segment band in optical coherence tomography of living frog retina.Journal of Biomedical Optics.  17:060504. 2012
2012 Comparative intrinsic optical signal imaging of wild-type and mutant mouse retinas.Optics Express.  20:7646-7654. 2012
2010 Activation of retinal guanylyl cyclase RetGC1 by GCAP1: stoichiometry of binding and effect of new LCA-related mutations.Biochemistry.  49:709-717. 2010
2009 Knockout of GARPs and the β-subunit of the rod cGMP-gated channel disrupts disk morphogenesis and rod outer segment structural integrity.Journal of Cell Science.  122:1192-1200. 2009
2009 Characterization of a canine model of autosomal recessive retinitis pigmentosa due to a PDE6A mutation.Investigative Ophthalmology & Visual Science.  50:801-813. 2009
2007 Focus on molecules: rod photoreceptor cGMP-gated cation channel.Experimental Eye Research.  85:173-174. 2007
2007 Focus on molecules: rod cGMP phosphodiesterase type 6.Experimental Eye Research.  84:1-2. 2007
2005 Identifying photoreceptors in blind eyes caused by RPE65 mutations: Prerequisite for human gene therapy success.Proceedings of the National Academy of Sciences.  102:6177-6182. 2005
2004 Characterization of 3',5' cyclic nucleotide phosphodiesterase activity in Y79 retinoblastoma cells: absence of functional PDE6.Molecular Vision.  10:738-749. 2004
2004 Functional analysis of the rod photoreceptor cGMP phosphodiesterase alpha-subunit gene promoter: Nrl and Crx are required for full transcriptional activity.Journal of Biological Chemistry.  279:19800-19807. 2004
2002 Electroretinographic abnormalities in parents of patients with Leber congenital amaurosis who have heterozygous GUCY2D mutations.Archives of Ophthalmology -New Series-.  120:1325-1330. 2002
2001 Four novel mutations in the RPE65 gene in patients with Leber congenital amaurosis.Human Mutation.  18:164. 2001
2001 A PDE6A promoter fragment directs transcription predominantly in the photoreceptor.Biochemical and Biophysical Research Communications.  282:543-547. 2001
2001 Reproducible high efficiency gene transfer into Y79 retinoblastoma cells using adenofection.Journal of Neuroscience Methods.  106:1-7. 2001
2000 Rapid restoration of visual pigment and function with oral retinoid in a mouse model of childhood blindness.Proceedings of the National Academy of Sciences.  97:8623-8628. 2000
2000 Genomic organization of the human rod photoreceptor cGMP-gated cation channel beta-subunit gene.Gene.  245:311-318. 2000
1998 Structure and upstream region characterization of the human gene encoding rod photoreceptor cGMP phosphodiesterase alpha-subunit.Journal of Molecular Neuroscience.  10:235-250. 1998
1997 Cloning and expression of the glucocorticoid receptor from the squirrel monkey (Saimiri boliviensis boliviensis), a glucocorticoid-resistant primateJournal of Clinical Endocrinology and Metabolism.  82:465-472. 1997
1997 Cloning and expression of the glucocorticoid receptor from the squirrel monkey (Saimiri boliviensis boliviensis), a glucocorticoid-resistant primate.Journal of Clinical Endocrinology and Metabolism.  82:465-472. 1997
1996 Retinal-specific guanylate cyclase gene mutations in Leber's congenital amaurosis.Nature Genetics.  14:461-464. 1996
1996 Cell-specific expression of the rat secretogranin II promoter.Endocrinology.  137:3815-3822. 1996
1996 Gene structure and chromosome localization to 7q21.3 of the human rod photoreceptor transducin gamma-subunit gene (GNGT1).Genomics.  35:241-243. 1996
1996 The beta subunit of human rod photoreceptor cGMP-gated cation channel is generated from a complex transcription unit.FEBS Letters.  389:213-218. 1996
1996 Cell-specific expression of the rat secretogranin II promoterEndocrinology.  137:3815-3822. 1996
1995 Autosomal recessive retinitis pigmentosa caused by mutations in the alpha subunit of rod cGMP phosphodiesterase.Nature Genetics.  11:468-471. 1995
1995 In vivo requirement of protein prenylation for maintenance of retinal cytoarchitecture and photoreceptor structure.Journal of Cell Biology.  130:431-439. 1995
1995 cDNA, gene structure, and chromosomal localization of human GAR1 (CNCG3L), a homolog of the third subunit of bovine photoreceptor cGMP-gated channel.Genomics.  28:32-38. 1995
1995 KEELER,CLYDE,EDGAR (1900-1994) - IN-MEMORIAMExperimental Eye Research.  60:3-4. 1995
1995 Lysosomal chitobiase (CTB) and the G-protein gamma 5 subunit (GNG5) genes co-localize to human chromosome 1p22.Cytogenetics and Cell Genetics.  71:44-46. 1995
1994 Sequence of rho small GTP-binding protein cDNAs from human retina and identification of novel 5' end cloning artifacts.Experimental Eye Research.  59:235-237. 1994
1994 Human retinal guanylate cyclase (GUC2D) maps to chromosome 17p13.1.Genomics.  22:478-481. 1994
1994 A YAC contig of approximately 3 Mb from human chromosome 5q31-->q33.Genomics.  19:470-477. 1994
1993 In vivo biosynthesis of cholesterol in the rat retina.FEBS Letters.  335:234-238. 1993
1993 PCR analysis of DNA from 70-year-old sections of rodless retina demonstrates identity with the mouse rd defect.Proceedings of the National Academy of Sciences.  90:9616-9619. 1993
1993 Irish setter dogs affected with rod/cone dysplasia contain a nonsense mutation in the rod cGMP phosphodiesterase beta-subunit gene.Proceedings of the National Academy of Sciences.  90:3968-3972. 1993
1992 Primary structure of frog rhodopsin.FEBS Letters.  313:103-108. 1992
1992 Syntenic assignments of visual transduction genes in cattle.Genomics.  14:699-706. 1992
1992 INVITRO ISOPRENYLATION AND MEMBRANE ASSOCIATION OF MOUSE ROD PHOTORECEPTOR CGMP PHOSPHODIESTERASE ALPHA-SUBUNIT AND BETA-SUBUNIT EXPRESSED IN BACTERIAJournal of Biological Chemistry.  267:8458-8463. 1992
1992 In vitro isoprenylation and membrane association of mouse rod photoreceptor cGMP phosphodiesterase alpha and beta subunits expressed in bacteria.Journal of Biological Chemistry.  267:8458-8463. 1992
1992 Chromosome mapping of the rod photoreceptor cGMP phosphodiesterase beta-subunit gene in mouse and human: tight linkage to the Huntington disease region (4p16.3).Genomics.  12:750-754. 1992
1992 Primary structure and chromosomal localization of human and mouse rod photoreceptor cGMP-gated cation channel.Journal of Biological Chemistry.  267:6257-6262. 1992
1992 Novel morphological changes in rat retina induced by intravitreal injection of lovastatin.Experimental Eye Research.  54:149-152. 1992
1991 Identification of a nonsense mutation in the rod photoreceptor cGMP phosphodiesterase beta-subunit gene of the rd mouse.Proceedings of the National Academy of Sciences.  88:8322-8326. 1991
1991 Complete cDNA sequences of mouse rod photoreceptor cGMP phosphodiesterase alpha- and beta-subunits, and identification of beta'-, a putative beta-subunit isozyme produced by alternative splicing of the beta-subunit gene.FEBS Letters.  278:107-114. 1991
1991 HSV antigens and HSV DNA in avascular and vascularized lesions of human herpes simplex keratitis.Current Eye Research.  10 Suppl:63-68. 1991
1991 The molecular genetics of retinal photoreceptor proteins involved in cGMP metabolism.Progress in clinical and biological research.  362:33-66. 1991
1990 Mouse opsin. Gene structure and molecular basis of multiple transcripts.Journal of Biological Chemistry.  265:20563-20569. 1990
1990 Molecular characterization of human and bovine rod photoreceptor cGMP phosphodiesterase alpha-subunit and chromosomal localization of the human gene.Genomics.  6:272-283. 1990
1987 A new family of the poly-deoxyadenylated class of Drosophila transposable elements identified by a representative member at the dunce locus.Molecular and General Genetics MGG.  208:325-328. 1987
1987 An interchromosomal gene conversion of the Drosophila dunce locus identified with restriction site polymorphisms: a potential involvement of transposable elements in gene conversion.Molecular and General Genetics MGG.  208:315-324. 1987
1985 In vitro synthesis of rat brain hexokinase.BBA - Biochimica et Biophysica Acta.  843:186-192. 1985

Principal Investigator On

  • Development and Characterization of Mouse Models of RP59 DHDDS Deficiency  awarded by National Eye Institute/NIH/DHHS 2018 - 2022
  • UAB Vision Science Research Center  awarded by National Eye Institute/NIH/DHHS 2016 - 2021
  • UAB Vision Science Research Center - Admin-Core  awarded by National Eye Institute/NIH/DHHS 2016 - 2021
  • UAB Vision Science Research Center - Biostatistical Analysis Core  awarded by National Eye Institute/NIH/DHHS 2016 - 2021
  • UAB Vision Science Research Center - Mole/Cell Core  awarded by National Eye Institute/NIH/DHHS 2016 - 2021
  • Private Grant  awarded by PTC THERAPEUTICS, INC. 2015 - 2019
  • Analysis of Retina Rod Photoreceptor GARP and cGMP-Gated Channel  awarded by National Eye Institute/NIH/DHHS 2013 - 2018
  • Vision Science Research Center  awarded by National Eye Institute/NIH/DHHS 2010 - 2016
  • Vision Science Research Center P30 Core Grant - Administrative Core  awarded by National Eye Institute/NIH/DHHS 2010 - 2016
  • Vision Science Research Center P30 Core Grant - Molecular & Cellular Analysis  awarded by National Eye Institute/NIH/DHHS 2010 - 2016
  • Analysis of Retina Rod Photoreceptor GARP and cGMP-Gated Cation Channel  awarded by National Eye Institute/NIH/DHHS 2008 - 2012
  • Development of a Novel Drug-Based Molecular Therapy for A Class of Hereditary Retinal Degeneration  awarded by EyeSight Foundation of Alabama 2007 - 2011
  • Noninvasive Visualization and Analysis of Organ Systems Using OCT and Digital Fundus Photography  awarded by National Center for Research Resources/NIH/DHHS 2009 - 2010
  • Education And Training

  • Doctor of Philosophy in Biochemistry, Michigan State University
  • Full Name

  • Steven Pittler
  • Blazerid

  • pittler