Positions

Selected Publications

Academic Article

Year Title Altmetric
2020 NOX2 decoy peptides disrupt trauma-mediated neutrophil immunosuppression and protect against lethal peritonitisRedox Biology.  36. 2020
2020 Damage to red blood cells during whole blood storageJournal of Trauma and Acute Care Surgery.  89:344-350. 2020
2020 α-Tocopherol Attenuates the Severity of Pseudomonas aeruginosa-induced PneumoniaAmerican Journal of Respiratory Cell and Molecular Biology.  63:234-243. 2020
2020 The Response of the Anesthesia & Analgesia Community to COVID-19.Anesthesia and Analgesia.  131:1-2. 2020
2020 Virulent Pseudomonas aeruginosa infection converts antimicrobial amyloids into cytotoxic prionsThe FASEB Journal.  34:9156-9179. 2020
2020 Exoenzyme y contributes to end-organ dysfunction caused by pseudomonas aeruginosa pneumonia in critically ill patients: An exploratory studyToxins.  12. 2020
2020 Extracellular nucleic acid scavenging rescues rats from sulfur mustard analog-induced lung injury and mortalityArchives of Toxicology.  94:1321-1334. 2020
2020 Neuronal Wiskott-Aldrich syndrome protein regulates Pseudomonas aeruginosa-induced lung vascular permeability through the modulation of actin cytoskeletal dynamicsThe FASEB Journal.  34:3305-3317. 2020
2020 Anesthesia & Analgesia: A Journal for the Practicing Anesthesiologist GloballyAnesthesia and Analgesia.  130:31-33. 2020
2020 Associations of plasma angiopoietins-1 and-2 and angiopoietin-2/-1 ratios with measures of organ injury and clinical outcomes in children with sepsis: A preliminary reportPediatric Critical Care Medicine.  E874-E878. 2020
2020 Human Leukocyte Antigen-DR Deficiency and Immunosuppression-Related End-Organ Failure in SARS-CoV2 InfectionAnesthesia and Analgesia.  989-992. 2020
2020 The Response of the Anesthesia & Analgesia Community to COVID-19Anesthesia and Analgesia.  1-2. 2020
2019 Infection-induced endothelial amyloids impair memoryThe FASEB Journal.  33:10300-10314. 2019
2019 Plasma Angiopoietin-2/-1 Ratio is Elevated and Angiopoietin-2 Levels Correlate with Plasma Syndecan-1 Following Pediatric TraumaShock.  52:340-346. 2019
2019 Older Blood Is Associated With Increased Mortality and Adverse Events in Massively Transfused Trauma Patients: Secondary Analysis of the PROPPR TrialAnnals of Emergency Medicine.  73:650-661. 2019
2019 A Comparison of Outcomes of Trauma Patients With Ventilator-Associated Events by Diagnostic Criteria SetShock.  51:599-604. 2019
2019 Exaggerated interventricular dependence among trauma and burn patients: A relationship with kidney function—an exploratory studyAmerican Surgeon.  85:365-369. 2019
2019 An Increasing Neutrophil-to-Lymphocyte Ratio Trajectory Predicts Organ Failure in Critically-Ill Male Trauma Patients. An Exploratory Study.Healthcare.  7. 2019
2019 Characterizing red blood cell age exposure in massive transfusion therapy: the scalar age of blood index (SBI)Transfusion.  59:2699-2708. 2019
2019 Erratum: Correction: Role of heme in lung bacterial infection after trauma hemorrhage and stored red blood cell transfusion: A preclinical experimental study (PLoS Med (2018) 15:3 (e1002522) DOI: 10.1371/journal.pmed.1002522)PLoS Medicine.  16. 2019
2019 Haplotype analysis of SERPINE1 gene: Risk for aneurysmal subarachnoid hemorrhage and clinical outcomesMolecular Genetics and Genomic Medicine.  7. 2019
2018 Nosocomial pneumonia elicits an endothelial proteinopathy: Evidence for a source of neurotoxic amyloids in critically ill patientsAmerican Journal of Respiratory and Critical Care Medicine.  198:1575-1578. 2018
2018 Elevated Syndecan-1 after Trauma and Risk of Sepsis: A Secondary Analysis of Patients from the Pragmatic, Randomized Optimal Platelet and Plasma Ratios (PROPPR) TrialJournal of The American College of Surgeons.  227:587-595. 2018
2018 New legal framework for human subject research in France: A step forward? 2018
2018 Respiratory oxygen uptake is associated with survival in a cohort of ventilated trauma and burn patientsAmerican Journal of Emergency Medicine.  36:1439-1443. 2018
2018 Platelet transfusions improve hemostasis and survival in a substudy of the prospective, randomized PROPPR trialBlood Advances.  2:1696-1704. 2018
2018 Association of cystathionine beta-synthase polymorphisms and aneurysmal subarachnoid hemorrhageJournal of Neurosurgery.  128:1771-1777. 2018
2018 Associations between endothelin polymorphisms and aneurysmal subarachnoid hemorrhage, clinical vasospasm, delayed cerebral ischemia, and functional outcomeJournal of Neurosurgery.  128:1311-1317. 2018
2018 Instillation of hyaluronan reverses acid instillation injury to the mammalian blood gas barrier 2018
2018 Burn patients with infection-related ventilator associated complications have worse outcomes compared to those without ventilator associated events 2018
2018 Low Plasma ADAMTS13 Activity Is Associated with Coagulopathy, Endothelial Cell Damage and Mortality after Severe Paediatric TraumaThrombosis and Haemostasis.  118:676-687. 2018
2018 Role of heme in lung bacterial infection after trauma hemorrhage and stored red blood cell transfusion: A preclinical experimental studyPLoS Medicine.  15. 2018
2018 Anesthesia & Analgesia: Update and a Year in ReviewAnesthesia and Analgesia.  126:3-6. 2018
2018 Histone-Complexed DNA Fragments Levels are Associated with Coagulopathy, Endothelial Cell Damage, and Increased Mortality after Severe Pediatric TraumaShock.  49:44-52. 2018
2018 Risk factors for the development of acute respiratory distress syndrome following hemorrhageShock.  50:258-264. 2018
2017 The relationship between single and two-dimensional indices of left ventricular size using hemodynamic transesophageal echocardiography in trauma and burn patientsCritical Ultrasound Journal.  9. 2017
2017 The role of endothelial nitric oxide synthase −786 T/C polymorphism in cardiac instability following aneurysmal subarachnoid hemorrhageNitric Oxide: Biology and Chemistry.  71:52-56. 2017
2017 Echocardiographic correlates are associated with in-hospital mortality in trauma and burn patients 2017
2017 An Appraisal of the Carlisle-Stouffer-Fisher Method for Assessing Study Data Integrity and FraudAnesthesia and Analgesia.  125:1381-1385. 2017
2017 Association of Plasminogen Activator Inhibitor 1 (SERPINE1) Polymorphisms and Aneurysmal Subarachnoid HemorrhageWorld Neurosurgery.  105:672-677. 2017
2017 The research agenda for trauma critical careIntensive Care Medicine.  43:1340-1351. 2017
2017 Pseudomonas aeruginosa infection liberates transmissible, cytotoxic prion amyloidsThe FASEB Journal.  31:2785-2796. 2017
2017 A comparison of clinical characteristics and outcomes of ventilator-associated pneumonias among burn patients by diagnostic criteria setShock.  48:624-628. 2017
2017 Associations of Endothelin Polymorphisms and Aneurysm Size at Time of RuptureWorld Neurosurgery.  102:253-257. 2017
2017 Endothelin polymorphisms as a risk factor for cerebral aneurysm rebleeding following aneurysmal subarachnoid hemorrhageClinical Neurology and Neurosurgery.  157:65-69. 2017
2017 Assuring hospital supply of fresh red blood cells for critically ill patientsTransfusion.  57:1320-1321. 2017
2017 Endothelial Nitric Oxide Synthase Polymorphism Is Associated with Delayed Cerebral Ischemia Following Aneurysmal Subarachnoid HemorrhageWorld Neurosurgery.  101:514-519. 2017
2017 Impact of High-Mobility Group Box 1 Polymorphism on Delayed Cerebral Ischemia After Aneurysmal Subarachnoid HemorrhageWorld Neurosurgery.  101:325-330. 2017
2017 Ryanodine Receptor 1 Polymorphism Is Not Associated with Aneurysmal Subarachnoid Hemorrhage or its Clinical SequelaeWorld Neurosurgery.  100:190-194. 2017
2017 Frontline science: D1 dopaminergic receptor signaling activates the AMPK-bioenergetic pathway in macrophages and alveolar epithelial cells and reduces endotoxininduced ALIJournal of Leukocyte Biology.  101:357-365. 2017
2017 Acute brain trauma, lung injury, and pneumonia: More than just altered mental status and decreased airway protection 2017
2017 Early coagulopathy is associated with increased incidence of ventilator-associated events among burn patientsShock.  47:107-110. 2017
2017 Maybe the Wand Does Matter?Anesthesia and Analgesia.  124:7-8. 2017
2017 The continued importance of basic science and the continued challenges of translating its findings into clinical practiceAnesthesia and Analgesia.  124:1034-1035. 2017
2017 The effect of implementation of preoperative and postoperative care elements of a perioperative surgical home model on outcomes in patients undergoing hip arthroplasty or knee arthroplastyAnesthesia and Analgesia.  124:1450-1458. 2017
2016 Absorbance and redox based approaches for measuring free heme and free hemoglobin in biological matricesRedox Biology.  9:167-177. 2016
2016 Continuing the Terra Firma and Establishing a New EQUATOR for Anesthesia & AnalgesiaAnesthesia and Analgesia.  123:8-9. 2016
2016 Neuronal Wiskott-Aldrich syndrome protein regulates TGF-β1-mediated lung vascular permeabilityThe FASEB Journal.  30:2557-2569. 2016
2016 Replicability, Reproducibility, and Fragility of Research Findings-Ultimately, Caveat EmptorAnesthesia and Analgesia.  123:244-248. 2016
2016 Early trauma-induced coagulopathy is associated with increased ventilator-associated pneumonia in spinal cord injury patientsShock.  45:502-505. 2016
2016 The glycocalyx and trauma: A reviewShock.  45:338-348. 2016
2016 Management of the traumatized airwayAnesthesiology.  124:199-206. 2016
2015 Trauma, critical care, and emergency care anesthesiology: A new paradigm for the "Acute Care" anesthesiologist?Anesthesia and Analgesia.  121:1668-1673. 2015
2015 AMP-activated protein kinase and glycogen synthase kinase 3β modulate the severity of sepsis-induced lung injuryMolecular Medicine.  21:937-950. 2015
2015 Red blood cell washing, nitrite therapy, and antiheme therapies prevent stored red blood cell toxicity after trauma-hemorrhageFree Radical Biology and Medicine.  85:207-218. 2015
2015 Synergistic Inhibition of β2-adrenergic Receptor-mediated Alveolar Epithelial Fluid Transport by Interleukin-8 and Transforming Growth Factor-βAnesthesiology.  122:1084-1092. 2015
2015 The coagulopathy of acute sepsisCurrent Opinion in Anaesthesiology.  28:227-236. 2015
2015 Tranexamic acid: From trauma to routine perioperative useCurrent Opinion in Anaesthesiology.  28:191-200. 2015
2015 Transfusion of plasma, platelets, and red blood cells in a 1:1:1 vs a 1:1:2 ratio and mortality in patients with severe trauma: The PROPPR randomized clinical trial 2015
2015 Revealing the real risks of perioperative transfusion: Rise of the machines!Anesthesiology.  122:1-2. 2015
2015 Revealing the real risks of perioperative transfusion: rise of the machines!Anesthesiology.  122:1-2. 2015
2015 The perioperative surgical home: A panacea or pandora's box for the specialty of anesthesiology?Anesthesia and Analgesia.  120:968-973. 2015
2015 World alliance against antibiotic resistance: The WAAAR declaration against antibiotic resistanceMedicina Intensiva.  39:34-39. 2015
2014 Hypotensive Resuscitation.Current Anesthesiology Reports.  4:209-215. 2014
2014 Postexposure aerosolized heparin reduces lung injury in chlorine-exposed mice 2014
2014 Trauma-Induced Coagulopathy.Current Anesthesiology Reports.  4:189-199. 2014
2014 Human resistin promotes neutrophil proinflammatory activation and neutrophil extracellular trap formation and increases severity of acute lung injuryJournal of Immunology.  192:4795-4803. 2014
2014 A more clinically relevant model of ventilator-associated pneumonia?Anesthesiology.  120:1075-1077. 2014
2014 A novel tumor necrosis factor-mediated mechanism of direct epithelial sodium channel activationAmerican Journal of Respiratory and Critical Care Medicine.  190:522-532. 2014
2014 Coagulopathy after severe pediatric traumaShock.  41:476-490. 2014
2014 Heat-shock response increases lung injury caused by pseudomonas aeruginosa via an Interleukin-10-dependent mechanism in miceAnesthesiology.  120:1450-1462. 2014
2014 Hypotensive resuscitation in a head-injured multi-trauma patientJournal of Critical Care.  29:313.e1-313.e5. 2014
2014 Inflammatory response to trauma: Implications for coagulation and resuscitationCurrent Opinion in Anaesthesiology.  27:246-252. 2014
2014 The perioperative surgical home: How anesthesiology can collaboratively achieve and leverage the triple aim in health careAnesthesia and Analgesia.  118:1131-1136. 2014
2013 An analysis of methodologies that can be used to validate if a perioperative surgical home improves the patient-centeredness, evidence-based practice, quality, safety, and value of patient careAnesthesiology.  119:1261-1274. 2013
2013 A checklist for trauma and emergency anesthesiaAnesthesia and Analgesia.  117:1178-1184. 2013
2013 Protein C and acute inflammation: A clinical and biological perspective 2013
2013 Targeting aspiration pneumonitisAnesthesiology.  119:752-754. 2013
2013 Patient satisfaction with anesthesia: Beauty is in the eye of the consumerAnesthesiology.  119:245-247. 2013
2013 HMGB1 Accelerates Alveolar Epithelial Repair via an IL-1β- and αvβ6 Integrin-dependent Activation of TGF-β1PLoS ONE.  8. 2013
2013 Early coagulopathy is an independent predictor of mortality in children after severe traumaShock.  39:421-426. 2013
2013 The Perioperative Surgical Home: How can it make the case so everyone wins?BMC Anesthesiology.  13. 2013
2013 HMGB1 promotes neutrophil extracellular trap formation through interactions with Toll-like receptor 4 2013
2013 IL-8 inhibits cAMP-stimulated alveolar epithelial fluid transport via a GRK2/PI3K-dependent mechanismThe FASEB Journal.  27:1095-1106. 2013
2013 Activation of the heat shock response attenuates the interleukin 1β-mediated inhibition of the amiloride-sensitive alveolar epithelial ion transportShock.  39:189-196. 2013
2012 Protein kinase C-α and arginase I mediate pneumolysin-induced pulmonary endothelial hyperpermeabilityAmerican Journal of Respiratory Cell and Molecular Biology.  47:445-453. 2012
2012 Stroke-induced activation of the α7 nicotinic receptor increases Pseudomonas aeruginosa lung injuryThe FASEB Journal.  26:2919-2929. 2012
2012 Critical role of activated protein C in early coagulopathy and later organ failure, infection and death in trauma patientsAnnals of Surgery.  255:379-385. 2012
2011 Cytoprotective-selective activated protein C attenuates pseudomonas aeruginosa - Induced lung injury in miceAmerican Journal of Respiratory Cell and Molecular Biology.  45:632-641. 2011
2011 Mouse and human lung fibroblasts regulate dendritic cell trafficking, airway inflammation, and fibrosis through integrin αvβ8 - Mediated activation of TGF-βJournal of Clinical Investigation.  121:2863-2875. 2011
2011 Active and passive cigarette smoking and acute lung injury after severe blunt traumaAmerican Journal of Respiratory and Critical Care Medicine.  183:1660-1665. 2011
2011 ANGPT2 genetic variant is associated with trauma-associated acute lung injury and altered plasma angiopoietin-2 isoform ratioAmerican Journal of Respiratory and Critical Care Medicine.  183:1344-1353. 2011
2011 Therapies against virulence products of staphylococcus aureus and pseudomonas aeruginosa 2011
2011 PAI-1 is an essential component of the pulmonary host response during Pseudomonas aeruginosa pneumonia in miceThorax.  66:788-796. 2011
2010 Reappraising the concept of massive transfusion in trauma 2010
2010 1H-NMR-based metabolic signatures of clinical outcomes in trauma patients-beyond lactate and base deficit 2010
2010 Serotonin decreases alveolar epithelial fluid transport via a direct inhibition of the epithelial sodium channelAmerican Journal of Respiratory Cell and Molecular Biology.  43:99-108. 2010
2010 Early release of soluble receptor for advanced glycation endproducts after severe trauma in humans 2010
2010 Alveolar dead-space response to activated protein c in acute respiratory distress syndrome 2010
2010 Transforming growth factor β1 inhibits cystic fibrosis transmembrane conductance regulator-dependent cAMP-stimulated alveolar epithelial fluid transport via a phosphatidylinositol 3-kinase-dependent mechanismJournal of Biological Chemistry.  285:4278-4290. 2010
2010 Activation of the stress protein response inhibits the STAT1 signalling pathway and iNOS function in alveolar macrophages: Role of Hsp90 and Hsp70Thorax.  65:346-353. 2010
2010 Critical role of the small GTPase RhoA in the development of pulmonary edema induced by pseudomonas aeruginosa in miceAnesthesiology.  113:1134-1143. 2010
2010 Leukocyte chemotaxis and migration: Can we follow the cellsAnesthesiology.  113:512-513. 2010
2010 The lectin-like doMain of tumor necrosis factor improves lung function after rat lung transplantation-Potential role for a reduction in reactive oxygen species generationCritical Care Medicine.  38:871-878. 2010
2010 University of California research seminar network: A prospectusPLoS Biology.  8. 2010
2009 Increase in activated protein C mediates acute traumatic coagulopathy in miceShock.  32:659-665. 2009
2009 Protein C depletion early after trauma increases the risk of ventilator-associated pneumonia 2009
2009 Early release of high mobility group box nuclear protein 1 after severe trauma in humans: role of injury severity and tissue hypoperfusion. 2009
2009 Role of small GTPases and αvβ5 integrin in Pseudomonas aeruginosa-induced increase in lung endothelial permeabilityAmerican Journal of Respiratory Cell and Molecular Biology.  40:108-118. 2009
2008 Role of integrin αvβ6 in acute lung injury induced by Pseudomonas aeruginosaInfection and Immunity.  76:2325-2332. 2008
2008 Acute coagulopathy of trauma: Hypoperfusion induces systemic anticoagulation and hyperfibrinolysis 2008
2008 Interleukin-1β causes acute lung injury via αvβ5 and αvβ6 integrin-dependent mechanismsCirculation Research.  102:804-812. 2008
2008 Angiopoietin-2, marker and mediator of endothelial activation with prognostic significance early after trauma?Annals of Surgery.  247:320-326. 2008
2008 Protection from experimental ventilator-induced acute lung injury by IL-1 receptor blockadeThorax.  63:147-153. 2008
2008 Regulation of apoptotic and inflammatory cell signaling in cerebral ischemia: The complex roles of heat shock protein 70Anesthesiology.  109:339-348. 2008
2008 Sevoflurane but not propofol increases interstitial glycolysis metabolites availability during tourniquet-induced ischaemia-reperfusionBritish Journal of Anaesthesia.  100:29-35. 2008
2008 Treating lung infections with anticoagulation: Mechanisms matterCritical Care Medicine.  36:356-357. 2008
2007 Role of the alternative pathway in the early complement activation following major traumaShock.  28:29-34. 2007
2007 Acute traumatic coagulopathy: Initiated by hypoperfusion: Modulated through the protein C pathway?Annals of Surgery.  245:812-818. 2007
2007 Sensitization of mesothelioma cells to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by heat stress via the inhibition of the 3-phosphoinositide-dependent kinase 1/Akt pathwayCancer Research.  67:2865-2871. 2007
2007 Early coagulopathy after traumatic brain injury: the role of hypoperfusion and the protein c pathway 2007
2006 Extracellular heat shock protein 72 is a marker of the stress protein response in acute lung injury 2006
2006 Activation of the stress protein response prevents the development of pulmonary edema by inhibiting VEGF cell signaling in a model of lung ischemia-reperfusion injury in ratsThe FASEB Journal.  20. 2006
2006 Decreasing ventilator-associated pneumonia in a trauma ICU 2006
2006 Bring rapidly degradable hydroxyethyl starch to the United States [5]Anesthesiology.  104:1105-1106. 2006
2006 Angiopoietin-2: Modulator of vascular permeability in acute lung injury?PLoS Medicine.  3:294-296. 2006
2006 Bombesin-like peptides: Modulators of inflammation in acute lung injury?American Journal of Respiratory and Critical Care Medicine.  173:1-2. 2006
2005 Polyethylene glycol-surfactant for lavage lung injury in ratsPediatric Research.  58:913-918. 2005
2005 Serum levels of Hsp60 correlate with the development of acute lung injury after traumaJournal of Surgical Research.  126:41-47. 2005
2005 Interleukin-1β decreases expression of the epithelial sodium channel α-subunit in alveolar epithelial cells via a p38 MAPK-dependent signaling pathwayJournal of Biological Chemistry.  280:18579-18589. 2005
2005 Clinical implementation of the ARDS network protocol is associated with reduced hospital mortality compared with historical controlsCritical Care Medicine.  33:925-929. 2005
2005 HO-1 induction restores c-AMP-dependent lung epithelial fluid transport following severe hemorrhage in ratsThe FASEB Journal.  19:287-289. 2005
2005 In vivo stress preconditioningMethods.  35:158-164. 2005
2005 Stress-induced inhibition of the NF-κB signaling pathway results from the insolubilization of the IκB kinase complex following its dissociation from heat shock protein 90Journal of Immunology.  174:384-394. 2005
2004 Acute respiratory distress syndrome criteria in trauma patients: Why the definitions do not work 2004
2004 Apoptosis inhibition in P. aeruginosa-induced lung injury influences lung fluid balanceIntensive Care Medicine.  30:1204-1211. 2004
2004 Prognostic value of the pulmonary dead-space fraction during the first 6 days of acute respiratory distress syndrome. 2004
2004 Standard preoxygenation technique versus two rapid techniques in pregnant patientsInternational Journal of Obstetric Anesthesia.  13:11-14. 2004
2004 The impact of hypoxia and hyperventilation on outcome after paramedic rapid sequence intubation of severely head-injured patients 2004
2003 Transforming Growth Factor-β1 Decreases Expression of the Epithelial Sodium Channel αENaC and Alveolar Epithelial Vectorial Sodium and Fluid Transport via an ERK1/2-dependent MechanismJournal of Biological Chemistry.  278:43939-43950. 2003
2003 Description and evaluation of a delivery system for aerosolized prostacyclin 2003
2003 High tidal volume ventilation induces NOS2 and impairs cAMP-dependent air space fluid clearance 2003
2003 Postdural puncture headache in a parturient with sickle cell disease: Use of an epidural colloid patch 2003
2003 The development of acute lung injury is associated with worse neurologic outcome in patients with severe traumatic brain injury 2003
2003 The development of acute lung injury is associated with worse neurologic outcome in patients with severe traumatic brain injury 2003
2002 Chronic bronchial allergic inflammation increases alveolar liquid clearance by TNF-α-dependent mechanism 2002
2002 Pulmonary dead-space fraction as a risk factor for death in the acute respiratory distress syndromeNew England Journal of Medicine.  346:1281-1286. 2002
2002 Stress preconditioning attenuates oxidative injury to the alveolar epithelium of the lung following haemorrhage in rats 2002
2002 Lidocaine induces a reversible decrease in alveolar epithelial fluid clearance in ratsAnesthesiology.  96:392-399. 2002
2002 Serum levels of hsup 72 measured early after trauma correlate with survival 2002
2001 Reactive nitrogen species inhibit alveolar epithelial fluid transport after hemorrhagic shock in ratsJournal of Immunology.  166:6301-6310. 2001
2001 Geldanamycin inhibits NF-κB activation and interleukin-8 gene expression in cultured human respiratory epitheliumAmerican Journal of Respiratory Cell and Molecular Biology.  25:92-97. 2001
2001 TGF-β is a critical mediator of acute lung injuryJournal of Clinical Investigation.  107:1537-1544. 2001
2000 Global analysis of gene expression in pulmonary fibrosis reveals distinct programs regulating lung inflammation and fibrosis 2000
2000 Ethanol ingestion via glutathione depletion impairs alveolar epithelial barrier function in rats 2000
2000 Initial severity of metabolic acidosis predicts the development of acute lung injury in severely traumatized patientsCritical Care Medicine.  28:125-131. 2000
2000 Keratinocyte growth factor protects against Pseudomonas aeruginosa-induced lung injury 2000
2000 Measuring intra-esophageal pressure to assess transmural pulmonary arterial occlusion pressure in patients with acute lung injury: A case series and review 2000
2000 Spontaneous high systemic oxygen delivery increases survival rate in awake sheep during sustained endotoxemiaCritical Care Medicine.  28:496-503. 2000
1999 Biological markers of acute lung injury: Prognostic and pathogenetic significance 1999
1999 The effects of two antiinflammatory pretreatments on bacterial-induced lung injuryAnesthesiology.  90:1650-1662. 1999
1999 The integrin αvβ6 binds and activates latent TGFβ1: A mechanism for regulating pulmonary inflammation and fibrosisCell.  96:319-328. 1999
1999 Acid-induced lung injury: Protective effect of anti-interleukin-8 pretreatment on alveolar epithelial barrier function in rabbitsAmerican Journal of Respiratory and Critical Care Medicine.  160:1450-1456. 1999
1999 Alpha-toxin damages the air-blood barrier of the lung in a rat model of Staphylococcus aureus-induced pneumoniaInfection and Immunity.  67:5541-5544. 1999
1999 Effects of antibiotic therapy on Pseudomonas aeruginosa-induced lung injury in a rat modelAntimicrobial Agents and Chemotherapy.  43:2389-2394. 1999
1999 Geldanamycin inhibits interleukin-8 gene expression in cultured human respiratory epitheliumCritical Care Medicine.  27. 1999
1999 Inhaled nitric oxide [3] (multiple letters)Critical Care Medicine.  27:848-849. 1999
1999 Interleukin-8 mediates injury from smoke inhalation to both the lung endothelial and the alveolar epithelial barriers in rabbitsAmerican Journal of Respiratory and Critical Care Medicine.  160:1443-1449. 1999
1999 Withdrawal syndrome and tolerance to sedatives and analgesics in intensive care unit patients [4] (multiple letters)Critical Care Medicine.  27:2602-2604. 1999
1999 α-Adrenergic blockade restores normal fluid transport capacity of alveolar epithelium after hemorrhagic shock 1999
1998 Irish thoracic society - Proceeds of annual scientific meeting held Friday & Saturday 8th & 9th November, 1996Irish Journal of Medical Science.  167:1-13. 1998
1998 Acute withdrawal syndrome related to the administration of analgesic and sedative medications in adult intensive care unit patientsCritical Care Medicine.  26:676-684. 1998
1998 Just say NO to inhaled nitric oxide for the acute respiratory distress syndromeCritical Care Medicine.  26:1-2. 1998
1998 Endothelial exposure to Pseudomonas aeruginosa proteases increases the vulnerability of the alveolar epithelium to a second injuryAmerican Journal of Respiratory Cell and Molecular Biology.  18:129-135. 1998
1998 Placebo and inhaled nitric oxide mortality the same in ARDS clinical trial [1] (multiple letters)Critical Care Medicine.  26:619. 1998
1997 Biochemical detection of type I cell damage after nitrogen dioxide- induced lung injury in rats 1997
1997 Biological markers of acute lung injury: Prognostic and pathogenetic significanceAmerican Journal of Respiratory and Critical Care Medicine.  155:1187-1205. 1997
1997 Nitric oxide attenuates lung endothelial injury caused by sublethal hyperoxia in rats 1997
1997 Upregulation of alveolar liquid clearance after fluid resuscitation for hemorrhagic shock in rats 1997
1996 Intraluminal water increases expression of plasmid DNA in rat lungHuman Gene Therapy.  7:933-941. 1996
1996 The critical role of the alveolar epithelial barrier in acute lung injury 1996
1996 Doxacurium pharmacodynamics in children during volatile and opioid-based anaesthesiaAnaesthesia.  51:361-364. 1996
1996 Aerosolization of imipenem/cilastatin prevents pseudomonas-induced acute lung injuryJournal of Antimicrobial Chemotherapy.  38:809-818. 1996
1996 Alveolar liquid clearance is increased by endogenous catecholamines in hemorrhagic shock in rats 1996
1996 Depletion of alveolar macrophages decreases neutrophil chemotaxis to Pseudomonas airspace infections 1996
1996 Exotoxin A stimulates fluid reabsorption from distal airspaces of lung in anesthetized rats 1996
1996 Transforming growth factor-α increases alveolar liquid clearance in anesthetized ventilated rats 1996
1996 Transient permeabilization of airway epithelium by mucosal water 1996
1995 Pharmacokinetics of pipecuronium in infants, children and adults 1995
1995 The effect of pentoxifylline on acid-induced alveolar epithelial injuryAnesthesiology.  82:531-541. 1995
1995 A type I cell-specific protein is a biochemical marker of epithelial injury in a rat model of pneumonia 1995
1995 Expression of the β6 integrin subunit in development, neoplasia and tissue repair suggests a role in epithelial remodelingJournal of Cell Science.  108:2241-2251. 1995
1995 Resistance of the alveolar epithelium to injury from septic shock in sheepAmerican Journal of Respiratory and Critical Care Medicine.  151:1093-1100. 1995
1994 Alveolar liquid and protein clearance in anesthetized ventilated rats 1994
1994 Exoproduct secretions of Pseudomonas aeruginosa strains influence severity of alveolar epithelial injury 1994
1994 Novel Pseudomonas product stimulates interleukin-8 production in airway epithelial cells in vitroJournal of Clinical Investigation.  93:26-32. 1994
1994 Stimulation of lung epithelial liquid clearance by endogenous release of catecholamines in septic shock in anesthetized ratsJournal of Clinical Investigation.  94:663-671. 1994
1994 Vecuronium neuromuscular blockade reflects liver function during hepatic autotransplantation in pigsAnesthesiology.  81:168-175. 1994
1993 Alveolar epithelial injury and pleural empyema in acute P. aeruginosa pneumonia in anesthetized rabbits 1993
1993 Alveolar liquid and protein clearance in the absence of blood flow or ventilation in sheep 1993
1993 Pseudomonas aeruginosa-induced lung and pleural injury in sheep. Differential protective effect of circulating versus alveolar immunoglobulin G antibodyJournal of Clinical Investigation.  92:1221-1228. 1993
1992 Different effects of prostacyclin and phentolamine on delivery-dependent O2 consumption and skin microcirculation after cardiac surgery 1992
1992 Neuropeptides in pulmonary edema fluid of adult respiratory distress syndromeInflammation.  16:509-517. 1992
1992 Xanthine derivative HWA 138 attenuates hemodynamic and oxygen uptake dysfunction secondary to severe endotoxin shock in sheepCirculatory shock.  36:113-119. 1992
1991 Alveolar and lung liquid clearance in anesthetized rabbits 1991
1991 Elevated plasma endothelin-1 concentrations are associated with the severity of illness in patients with sepsisAnnals of Surgery.  213:261-264. 1991
1991 Imbalance between plasma levels of thromboxane B2 and 6-keto-prostaglandin F(1α) during subacute endotoxin-induced hyperdynamic sepsis or multiple organ failure syndrome in sheepCirculatory shock.  35:65-77. 1991
1991 New technique using [125I]labeled rose bengal for the quantification in blood samples of pipecuronium bromide, a muscle relaxant drugJournal of Labelled Compounds and Radiopharmaceuticals.  29:547-556. 1991
1991 Superoxide production by peripheral blood monocytes during sustained endotoxaemia in sheepClinical Science.  81:815-822. 1991
1991 Time course of plasma and pulmonary lymph endothelin-like immunoreactivity during sustained endotoxaemia in chronically instrumented sheepClinical Science.  81:357-365. 1991
1990 Adverse cardiopulmonary effects and increased plasma thromboxane concentrations following the neutralization of heparin with protamine in awake sheep are infusion rate-dependentAnesthesiology.  73:415-424. 1990
1990 Differential effect of two vasodilators on oxygen supply-demand ratio and skin microcirculatory blood flow in patients after cardiac surgery 1990
1990 Dose requirements and plasma concentrations of pipecuronium during bilateral renal exclusion and orthotopic liver transplantation in pigsBritish Journal of Anaesthesia.  65:779-785. 1990
1990 Effect of volatile anesthetics on vecuronium-induced neuromuscular blockade in childrenAnesthesia and Analgesia.  70:248-252. 1990
1990 High frequency jet ventilation and intermittent positive pressure ventilation. Effect of cerebral blood flow in patients after open heart surgeryChest.  97:420-424. 1990
1990 Neuromuscular effect of pipecuronium bromide in infants and children during nitrous oxide-alfentanil anesthesiaAnesthesiology.  72:432-435. 1990
1990 Plasma concentrations of laudanosine, but not of atracurium, are increased during the anhepatic phase of orthotopic liver transplantation in pigsAnesthesiology.  72:145-152. 1990
1990 Predictive value of frc and respiratory compliance on pulmonary gas exchange induced by high frequency jet ventilation in humansBritish Journal of Anaesthesia.  64:460-468. 1990
1990 Prostacyclin but not phentolamine increases oxygen consumption and skin microvascular blood flow in patients with sepsis and respiratory failureChest.  98:1467-1472. 1990
1990 The ḊO2/V̇O2 relationship: An approach to cellular metabolism in 'crisis' situationsSwiss Medical Weekly.  120:1192-1199. 1990
1989 Pharmacokinetics of atracurium besylate in the pig after a single i.v. injection 1989
1989 Increased plasma and pulmonary lymph levels of endothelin during endotoxin shock 1989
1989 Effect of the knee-chest position on cerebral blood flow in patients undergoing lumbar spinal surgeryJournal of Neurology, Neurosurgery and Psychiatry.  52:1277-1280. 1989
1989 Pipecuronium-induced neuromuscular blockade during nitrous oxide-fentanyl, isoflurane, and halothane anesthesia in adults and childrenAnesthesiology.  71:210-213. 1989
1989 Regulation of high frequency ventilation combined with conventional mechanical ventilation 1989
1988 Cardiovascular effects of pipecuronium and pancuronium in patients undergoing coronary artery bypass graftingAnesthesiology.  69:793-796. 1988
1988 Pathophysiological mechanisms of venous admixture during general anesthesiaAnnales Françaises d'Anesthésie et de Réanimation.  7:46-58. 1988
1987 Postoperative low cardiac output syndrome 1987
1987 Effects of different respiratory supports on cerebral haemodynamicsAgressologie: revue internationale de physio-biologie et de pharmacologie appliquees aux effets de l'agression.  28:267-270. 1987
1987 Pharmacology and toxicity of local anestheticsSchweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis.  76:865-871. 1987
1987 Physiopathology of gas exchange during general anesthesiaMedecine et Hygiene.  45:3104-3112. 1987
1987 Prevention and treatment of complications of local anestheticsSchweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis.  76:872-874. 1987
1986 Pharmacology of the major analgesics: Mechanism of action, pharmacokinetics and pharmacodynamics (I)Medecine et Hygiene.  44:2761-2766. 1986
1986 Pharmacology of the major analgesics: Mechanism of action, pharmacokinetics and pharmacodynamics (II)Medecine et Hygiene.  44:2768-2770. 1986
1983 The antiarrhythmic drug quinidine, an alternative in the treatment of severe falciparum malariaSwiss Medical Weekly.  113:254-258. 1983

Book

Year Title Altmetric
2014 Practical understanding of hemostasis and approach to the bleeding patient in the operating room.  Ed. 32.  2014

Chapter

Year Title Altmetric
2012 Pain Management in The Intensive Care Unit.  504-511. 2012
2012 Use of Paralytic Agents in The Intensive Care Unit.  497-503. 2012
2007 Pain Management in the Intensive Care Unit.  474-480. 2007
2007 Use of Paralytic Agents in the Intensive Care Unit.  467-473. 2007
2003 Heat shock response, heat shock proteins, and acute lung injury.  254-274. 2003

Principal Investigator On

  • Regulation of Phosphodiesterases and cAMP Signaling During the Host-Pathogen Interaction in the Pulmonary Endothelium  awarded by University of South Alabama 2018 - 2022
  • Nosocomial Pneumonias Impair Cognitive Function  awarded by University of South Alabama 2018 - 2021
  • Scheduled Prophylactic 6-Hourly IV Acetaminophen to Prevent Postoperative Delirium in Older Cardiac Surgical Patients: A Pragmatic Trial  awarded by BETH ISRAEL DEACONESS MEDICAL CENTER 2019 - 2020
  • The Role of Exo- Induced Tau Phosphorylation in the Development of Cognitive Dysfunction in ICU Patients after Nosocomial Pneumonia  awarded by University of South Alabama 2018 - 2020
  • Coagulation Abnormalities and Post-Traumatic Ventilator-Associated Pneumonia  awarded by National Institute of General Medical Sciences/NIH/DHHS 2010 - 2015
  • PDE4 and IL-8-Dependent Inhibition of cAMP-Stimulated Alveolar Fluid Clearance  awarded by Foundation for Anesthesia Education & Research 2013 - 2014
  • Effect of Antioxidant Vitamins on Coagulopathy and Nosocomial Pneumonia After Severe Trauma  awarded by NATIONAL TRAUMA INSTITUTE 2012 - 2013
  • Mechanisms of Coagulation Abnormalities and Trauma  awarded by University of California, San Francisco 2010 - 2012
  • Heat Shock and Lung Fluid Balance  awarded by National Institute of General Medical Sciences/NIH/DHHS 2010 - 2011
  • TLR2 in Sepsis-Induced Coagulopathy, Endothelial Leak, and Pulmonary Dysfunction  awarded by University of California, San Francisco 2010 - 2011
  • Investigator On

  • The Role of Sex Dimorphism in Post-TBI Bacterial Pneumonia  awarded by National Institute of General Medical Sciences/NIH/DHHS 2018 - 2023
  • Presence of Cytotoxic Amyloid and Tau in Plasma of COVID-19 Patients is Associated with End-Organ Dysfunction  awarded by University of South Alabama 2020 - 2022
  • Molecular Mechanism of Lung Barrier Dysfunction  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2018 - 2022
  • Therapeutic Recovery of Immune and Lung Tissue Bioenergetic Homeostasis in Sepsis-Induced Immunosuppression  awarded by DOD - Department of Defense 2017 - 2021
  • Coagulopathy Following Head Injury in Pediatric Trauma: From Bedside to Bench  awarded by KAUL PEDIATRIC RESEARCH INSTITUTE 2018 - 2020
  • Glycocalyx Mechanoregulation of Anglopoietln-2 and Post-Traumatic Lung Injury  awarded by DOD - Department of Defense 2018 - 2020
  • Coagulation Abnormalities after Severe Pediatric Trauma: Bench to Bedside  awarded by American College of Surgeons 2017 - 2019
  • Risk of Hospital-acquired Pneumonia is Increased by Cigarette Smoke-induced Impaired Host Defense  awarded by American Lung Association 2017 - 2019
  • Evaluation Of A Novel Hemostatic Agent In Junctional Trauma  awarded by DOD - Department of Defense 2018
  • Coagulation Following Out-of-Hospital Cardiac Arrest  awarded by Society of Critical Care Medicine 2016 - 2018
  • Mechanisms of Lung Immunosuppression after Traumatic Brain Injury  awarded by Foundation for Anesthesia Education & Research 2015 - 2017
  • Pragmatic, Randomized Optimal Platelet and Plasma Ratios (PROPPR)  awarded by UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER (HOUSTON) 2011 - 2015
  • Education And Training

  • Bachelor of Medicine & Surgery (MBBS), 1977
  • University of Lausanne, Residency 1980
  • Kantonspital (Switzerland), Postdoctoral Fellowship 1982
  • Full Name

  • Jean-Francois Pittet