Positions

Overview

  • I have lived most of my life in the Midwest and the South. I have always been most interested in science, math, and computing. In graduate school, I did computational research in the group of Dr. Peter Ford whose research is primarily inorganic photochemistry. It was there that I witnessed how computational research could complement bench-top results to enhance our understanding of chemical structures and reactions.

    After graduate school I did a postdoctoral fellowship with Dr. Jere Segrest in the department of Gerontology and Geriatric Medicine at UAB. I learned the fundamentals of molecular dynamics from Dr. Segrest’s long-time colleague Dr. Stephen Harvey, and I performed molecular dynamics simulations on lipid-bound apolipoproteins to gain a better understanding of their dynamic structures and interactions.

    After my postdoctoral fellowship I joined the Chemistry Department at UAB. My research primarily focuses on using computational methods to understand the mechanisms that give rise to the misfolding and aggregation of proteins that are implicated in neurological disorders like Alzheimer’s and Parkinson’s diseases. My teaching responsibilities include the first-year general chemistry courses for undergraduate science majors. I have also taught group theory and molecular orbital theory as part of our department’s foundations courses for graduate students.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2015 Surface Density-Induced Pleating of a Lipid Monolayer Drives Nascent High-Density Lipoprotein Assembly 2015
    2013 Molecular Dynamics Study of Zn(Aβ) and Zn(Aβ)2 2013
    2011 A CXCL8 receptor antagonist based on the structure of N-acetyl-proline- glycine-proline 2011
    2011 Molecular Dynamic Simulations of Apolipoprotein A-I peptide Mimetics 2011
    2011 Molecular Dynamics Simulations of Monomeric and Dimeric NAC in Alpha-Synuclein at Various Temperatures 2011
    2011 Molecular Dynamics Studies of Cu(II)-Bound -Synuclein(S) Complexes 2011
    2010 Structures of discoidal high density lipoproteins: A combined computational-experimental approach 2010
    2010 Molecular Dynamics Simulations of Alpha-Synuclein at Various Temperatures 2010
    2009 Thermal stability of apolipoprotein A-I in high-density lipoproteins by molecular dynamics 2009
    2008 Structure of spheroidal HDL particles revealed by combined atomistic and coarse-grained simulations (Biophysical Journal (2008) 94,6 (2306-2319)) 2008
    2008 Structure of spheroidal HDL particles revealed by combined atomistic and coarse-grained simulations 2008
    2007 Reactions of nitrogen oxides with the five-coordinate Fe III (porphyrin) nitrito intermediate Fe(Por)(ONO) in sublimed solids 2007
    2007 Molecular dynamics simulations of monomeric apolipoprotein A-I from a recent X-ray structure 2007
    2006 Novel changes in discoidal high density lipoprotein morphology: A molecular dynamics study 2006
    2005 Discoidal complexes of apolipoprotein A-I with different phospholipids share a common model for size heterogeneity 2005
    2004 DFT and experimental studies on the reaction of Fe(TPP)(NO3) with NO. 2004
    2003 Spectroscopic and density functional studies of the dinitrosyl metalloporphyrin complexes Fe(P)(NO)2 and Ru(P)(NO)2 2003
    2003 Density functional studies of M(L)X(NO)Y and related compounds as models for the reactivity of nitric oxide and metalloporphyrin nitrosyls. 2003
    2002 Luminescent metallo-organic clusters and polymers based on copper(I) halides. 2002

    Research Overview

  • My research is focused on using quantum mechanics and molecular dynamics to study proteins implicated in neurological disorders. My students and I perform quantum mechanics calculations to obtain accurate data which we use in our dynamics simulations. We use molecular dynamics simulations to study protein interactions with metal ions, small molecules, and biomolecules affect protein misfolding and aggregation. We have primarily studied proteins that are implicated in Alzheimer’s disease and Parkinson’s disease. We also use these computational methods to study the dynamic structures and behavior of some proteins and peptides that help prevent atherosclerosis.

    Keywords - Inorganic Chemistry, Biophysical Chemistry, Quantum Mechanics, Molecular Mechanics, Molecular Dynamics
  • Teaching Activities

  • CH105 - Introductory Chemistry I (Fall Term 2019) 2019
  • CH105R - Intro Chem I Rec (Fall Term 2019) 2019
  • CH105R - Intro Chem I Rec (Fall Term 2019) 2019
  • CH105R - Intro Chem I Rec (Fall Term 2019) 2019
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  • CH105R - Intro Chem I Rec (Fall Term 2019) 2019
  • CH106 - Introductory Chemistry I Lab (Fall Term 2019) 2019
  • CH106 - Introductory Chemistry I Lab (Fall Term 2019) 2019
  • CH106 - Introductory Chemistry I Lab (Fall Term 2019) 2019
  • CH106 - Introductory Chemistry I Lab (Fall Term 2019) 2019
  • CH106 - Introductory Chemistry I Lab (Fall Term 2019) 2019
  • CH106 - Introductory Chemistry I Lab (Fall Term 2019) 2019
  • CH106 - Introductory Chemistry I Lab (Fall Term 2019) 2019
  • CH106 - Introductory Chemistry I Lab (Fall Term 2019) 2019
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  • CH106 - Introductory Chemistry I Lab (Fall Term 2019) 2019
  • CH106 - Introductory Chemistry I Lab (Fall Term 2019) 2019
  • CH107 - Introductory Chemistry II (Fall Term 2019) 2019
  • CH107R - Intro Chem II Rec (Fall Term 2019) 2019
  • CH107R - Intro Chem II Rec (Fall Term 2019) 2019
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  • CH108 - Introductory Chemistry II Lab (Fall Term 2019) 2019
  • CH108 - Introductory Chemistry II Lab (Fall Term 2019) 2019
  • CH108 - Introductory Chemistry II Lab (Fall Term 2019) 2019
  • CH106 - Introductory Chemistry I Lab (Summer Term 2019) 2019
  • CH106 - Introductory Chemistry I Lab (Summer Term 2019) 2019
  • CH107 - Introductory Chemistry II (Summer Term 2019) 2019
  • CH107R - Intro Chem II Rec (Summer Term 2019) 2019
  • CH107R - Intro Chem II Rec (Summer Term 2019) 2019
  • CH108 - Introductory Chemistry II Lab (Summer Term 2019) 2019
  • CH108 - Introductory Chemistry II Lab (Summer Term 2019) 2019
  • CH798 - Non-Dissertation Research (Summer Term 2019) 2019
  • CH105R - Intro Chem I Rec (Spring Term 2019) 2019
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  • CH106 - Introductory Chemistry I Lab (Spring Term 2019) 2019
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  • CH106 - Introductory Chemistry I Lab (Spring Term 2019) 2019
  • CH106 - Introductory Chemistry I Lab (Spring Term 2019) 2019
  • CH106 - Introductory Chemistry I Lab (Spring Term 2019) 2019
  • CH106 - Introductory Chemistry I Lab (Spring Term 2019) 2019
  • CH106 - Introductory Chemistry I Lab (Spring Term 2019) 2019
  • CH106 - Introductory Chemistry I Lab (Spring Term 2019) 2019
  • CH107 - Introductory Chemistry II (Spring Term 2019) 2019
  • CH107 - Introductory Chemistry II (Spring Term 2019) 2019
  • CH107R - Intro Chem II Rec (Spring Term 2019) 2019
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  • CH108 - Introductory Chemistry II Lab (Spring Term 2019) 2019
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  • CH108 - Introductory Chemistry II Lab (Spring Term 2019) 2019
  • CH108 - Introductory Chemistry II Lab (Spring Term 2019) 2019
  • CH108 - Introductory Chemistry II Lab (Spring Term 2019) 2019
  • CH105 - Introductory Chemistry I (Fall Term 2018) 2018
  • CH105R - Intro Chem I Rec (Fall Term 2018) 2018
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  • CH106 - Introductory Chemistry I Lab (Fall Term 2018) 2018
  • CH106 - Introductory Chemistry I Lab (Fall Term 2018) 2018
  • CH106 - Introductory Chemistry I Lab (Fall Term 2018) 2018
  • CH106 - Introductory Chemistry I Lab (Fall Term 2018) 2018
  • CH106 - Introductory Chemistry I Lab (Fall Term 2018) 2018
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  • CH106 - Introductory Chemistry I Lab (Fall Term 2018) 2018
  • CH106 - Introductory Chemistry I Lab (Fall Term 2018) 2018
  • CH107 - Introductory Chemistry II (Fall Term 2018) 2018
  • CH107R - Intro Chem II Rec (Fall Term 2018) 2018
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  • CH108 - Introductory Chemistry II Lab (Fall Term 2018) 2018
  • CH108 - Introductory Chemistry II Lab (Fall Term 2018) 2018
  • CH108 - Introductory Chemistry II Lab (Fall Term 2018) 2018
  • CH106 - Introductory Chemistry I Lab (Summer Term 2018) 2018
  • CH106 - Introductory Chemistry I Lab (Summer Term 2018) 2018
  • CH107 - Introductory Chemistry II (Summer Term 2018) 2018
  • CH107R - Intro Chem II Rec (Summer Term 2018) 2018
  • CH107R - Intro Chem II Rec (Summer Term 2018) 2018
  • CH108 - Introductory Chemistry II Lab (Summer Term 2018) 2018
  • CH108 - Introductory Chemistry II Lab (Summer Term 2018) 2018
  • CH105R - Intro Chem I Rec (Spring Term 2018) 2018
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  • CH106 - Introductory Chemistry I Lab (Spring Term 2018) 2018
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  • CH106 - Introductory Chemistry I Lab (Spring Term 2018) 2018
  • CH106 - Introductory Chemistry I Lab (Spring Term 2018) 2018
  • CH106 - Introductory Chemistry I Lab (Spring Term 2018) 2018
  • CH106 - Introductory Chemistry I Lab (Spring Term 2018) 2018
  • CH106 - Introductory Chemistry I Lab (Spring Term 2018) 2018
  • CH106 - Introductory Chemistry I Lab (Spring Term 2018) 2018
  • CH107 - Introductory Chemistry II (Spring Term 2018) 2018
  • CH107 - Introductory Chemistry II (Spring Term 2018) 2018
  • CH107R - Intro Chem II Rec (Spring Term 2018) 2018
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  • CH108 - Introductory Chemistry II Lab (Spring Term 2018) 2018
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  • CH108 - Introductory Chemistry II Lab (Spring Term 2018) 2018
  • CH108 - Introductory Chemistry II Lab (Spring Term 2018) 2018
  • CH108 - Introductory Chemistry II Lab (Spring Term 2018) 2018
  • CH105 - Introductory Chemistry I (Fall Term 2017) 2017
  • CH105R - Intro Chem I Rec (Fall Term 2017) 2017
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  • CH106 - Introductory Chemistry I Lab (Fall Term 2017) 2017
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  • CH106 - Introductory Chemistry I Lab (Fall Term 2017) 2017
  • CH106 - Introductory Chemistry I Lab (Fall Term 2017) 2017
  • CH107 - Introductory Chemistry II (Fall Term 2017) 2017
  • CH107R - Intro Chem II Rec (Fall Term 2017) 2017
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  • CH108 - Introductory Chemistry II Lab (Fall Term 2017) 2017
  • CH108 - Introductory Chemistry II Lab (Fall Term 2017) 2017
  • CH108 - Introductory Chemistry II Lab (Fall Term 2017) 2017
  • CH107 - Introductory Chemistry II (Summer Term 2017) 2017
  • CH117 - General Chemistry II (Summer Term 2017) 2017
  • CH117R - General Chem II Recitation (Summer Term 2017) 2017
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  • CH117R - General Chem II Recitation (Summer Term 2017) 2017
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  • CH117 - General Chemistry II (Spring Term 2017) 2017
  • CH493 - Chemistry in Culture & Ethics (Spring Term 2017) 2017
  • CH495 - Ethics in Chemical Research (Spring Term 2017) 2017
  • CH117 - General Chemistry II (Fall Term 2016) 2016
  • CH117 - General Chemistry II (Fall Term 2016) 2016
  • CH117R - General Chem II Recitation (Fall Term 2016) 2016
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  • CH701 - Foundations of Org/Inorg Chem (Fall Term 2016) 2016
  • CH107 - Introductory Chemistry II (Summer Term 2016) 2016
  • CH115 - General Chemistry I (Summer Term 2016) 2016
  • CH115R - General Chemistry I Recitation (Summer Term 2016) 2016
  • CH115R - General Chemistry I Recitation (Summer Term 2016) 2016
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  • CH115 - General Chemistry I (Spring Term 2016) 2016
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  • CH117 - General Chemistry II (Spring Term 2016) 2016
  • CH493 - Chemistry in Culture & Ethics (Spring Term 2016) 2016
  • CH495 - Ethics in Chemical Research (Spring Term 2016) 2016
  • CH115 - General Chemistry I (Fall Term 2015) 2015
  • CH117 - General Chemistry II (Fall Term 2015) 2015
  • CH701 - Foundations of Org/Inorg Chem (Fall Term 2015) 2015
  • CH100 - Chemical Problem Solving (Summer Term 2015) 2015
  • CH115 - General Chemistry I (Summer Term 2015) 2015
  • CH115R - General Chemistry I Recitation (Summer Term 2015) 2015
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  • CH115 - General Chemistry I (Fall Term 2014) 2014
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  • CH701 - Foundations of Org/Inorg Chem (Fall Term 2014) 2014
  • CH100 - Chemical Problem Solving (Summer Term 2014) 2014
  • CH115 - General Chemistry I (Summer Term 2014) 2014
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  • CH115 - General Chemistry I (Fall Term 2013) 2013
  • CH115 - General Chemistry I (Fall Term 2013) 2013
  • CH701 - Foundations of Org/Inorg Chem (Fall Term 2013) 2013
  • CH115 - General Chemistry I (Summer Term 2013) 2013
  • CH115R - General Chemistry I Recitation (Summer Term 2013) 2013
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  • CH729 - Spec Topics in Physical Chem (Summer Term 2013) 2013
  • CH115 - General Chemistry I (Spring Term 2013) 2013
  • CH115 - General Chemistry I (Spring Term 2013) 2013
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  • CH115 - General Chemistry I (Fall Term 2012) 2012
  • CH701 - Foundations of Org/Inorg Chem (Fall Term 2012) 2012
  • CH115 - General Chemistry I (Summer Term 2012) 2012
  • CH115R - General Chemistry I Recitation (Summer Term 2012) 2012
  • CH115R - General Chemistry I Recitation (Summer Term 2012) 2012
  • CH115R - General Chemistry I Recitation (Summer Term 2012) 2012
  • CH115 - General Chemistry I (Spring Term 2012) 2012
  • CH115 - General Chemistry I (Spring Term 2012) 2012
  • CH115 - General Chemistry I (Fall Term 2011) 2011
  • CH701 - Foundations of Org/Inorg Chem (Fall Term 2011) 2011
  • CH115 - General Chemistry I (Spring Term 2011) 2011
  • CH115 - General Chemistry I (Fall Term 2010) 2010
  • CH701 - Foundations of Org/Inorg Chem (Fall Term 2010) 2010
  • CH115 - General Chemistry I (Spring Term 2010) 2010
  • CH115R - General Chemistry I Recitation (Spring Term 2010) 2010
  • CH115R - General Chemistry I Recitation (Spring Term 2010) 2010
  • CH115R - General Chemistry I Recitation (Spring Term 2010) 2010
  • CH115R - General Chemistry I Recitation (Spring Term 2010) 2010
  • CH115R - General Chemistry I Recitation (Spring Term 2010) 2010
  • CH115R - General Chemistry I Recitation (Spring Term 2010) 2010
  • CH115R - General Chemistry I Recitation (Spring Term 2010) 2010
  • CH115 - General Chemistry I (Fall Term 2009) 2009
  • CH115 - General Chemistry I (Spring Term 2009) 2009
  • CH115R - General Chemistry I Recitation (Spring Term 2009) 2009
  • CH115R - General Chemistry I Recitation (Spring Term 2009) 2009
  • CH115R - General Chemistry I Recitation (Spring Term 2009) 2009
  • CH115R - General Chemistry I Recitation (Spring Term 2009) 2009
  • CH115R - General Chemistry I Recitation (Spring Term 2009) 2009
  • CH115R - General Chemistry I Recitation (Spring Term 2009) 2009
  • CH115 - General Chemistry I (Fall Term 2008) 2008
  • CH701 - Foundations of Org/Inorg Chem (Fall Term 2008) 2008
  • Education And Training

  • Doctor of Philosophy in Chemistry, University of California Santa Barbara 2004
  • Bachelor of Science or Mathematics in Chemistry, Carleton College 1997
  • University of Alabama at Birmingham Gerontology and Geriatric Medicine, Postdoctoral Fellowship 2007
  • Full Name

  • James Patterson