Positions

Overview

  • Ashish Pathak, Ph.D., is an advanced research scientist in the Chemistry Department at Southern Research (SR), where he joined in 2009. His main research interests are medicinal chemistry approaches in the area of infectious diseases (anti-bacterials and anti-virals) and cancer, carbohydrates and saponins as immune stimulants, and vaccine adjuvants.

    Pathak received his doctorate in chemistry from University of Lucknow in Lucknow, India, in 1993. Subsequently, he completed post-doctoral studies at Central Institute of Medicinal Aromatic Plants, Lucknow, National Institute of Health Sciences, Tokyo, and SR in various aspects of phytochemistry, carbohydrates, and medicinal chemistry. He was assistant professor of organic chemistry at Western Illinois University in Macomb, Illinois, for four years prior to rejoining SR in 2009.

    Pathak is also an adjunct faculty in the Chemistry Department at the University of Alabama at Birmingham (UAB) and member of UAB’s Comprehensive Cancer Center.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2019 Studies on Dibenzylamines as Inhibitors of Venezuelan Equine Encephalitis Virus. 2019
    2019 Synthesis of Aza-acyclic Nucleoside Libraries of Purine, Pyrimidine, and 1,2,4-Triazole 2019
    2015 Benzimidazole analogs inhibit respiratory syncytial virus G protein function 2015
    2014 Unique functional and structural properties of the LRRK2 protein ATP-binding pocket 2014
    2014 Solution-phase parallel synthesis of acyclic nucleoside libraries of purine, pyrimidine, and triazole acetamides 2014
    2013 6-Oxo and 6-thio purine analogs as antimycobacterial agents 2013
    2012 Concise synthesis of an arabinofuranose hexasaccharide present in the cell wall of Mycobacterium tuberculosis 2012
    2011 A high-throughput screening assay for inhibitors of bacterial motility identifies a novel inhibitor of the Na + -driven flagellar motor and virulence gene expression in Vibrio cholerae 2011
    2011 Lipoarabinomannan biosynthesis in Corynebacterineae: The interplay of two α(1→2)-mannopyranosyltransferases MptC and MptD in mannan branching 2011
    2011 Synthesis and antibacterial activity of ciprofloxacin derivatives 2011
    2010 Antioxidant and anti-inflammatory potential of Pterospermum acerifolium 2010
    2009 Functional expression of Francisella tularensis FabH and FabI, potential antibacterial targets 2009
    2009 Synthesis of deoxygenated α(1 → 5)-linked arabinofuranose disaccharides as substrates and inhibitors of arabinosyltransferases of Mycobacterium tuberculosis 2009
    2009 Imidazolium cation supported solution-phase assembly of homolinear α(1→6)-linked octamannoside: An efficient alternate approach for oligosaccharide synthesis 2009
    2008 Concise assembly of linear α(1→6)-linked octamannan fluorescent probe 2008
    2008 Expression, purification and characterisation of soluble GlfT and the identification of a novel galactofuranosyltransferase Rv3782 involved in priming GlfT-mediated galactan polymerisation in Mycobacterium tuberculosis 2008
    2008 Oligomannan synthesis using ionic liquid supported glycosylation 2008
    2007 Evaluation of CNS activities of aerial parts of Jasminum multiflorum Andr. 2007
    2007 Disaccharide analogs as probes for glycosyltransferases in Mycobacterium tuberculosis 2007
    2007 Synthesis of symmetrical C- and pseudo-symmetrical O-linked disaccharide analogs for arabinosyltransferase inhibitory activity in Mycobacterium tuberculosis 2007
    2007 Evaluation of anthelmintic activity of leaves of Callistemon citrinus curtis 2007
    2007 Semi-synthesis of deoxyartemisinin 2007
    2006 Novel conjugate of moxifloxacin and carboxymethylated glucan with enhanced activity against Mycobacterium tuberculosis 2006
    2005 Erratum: Degradation of Quillaja saponaria Molina saponins: Loss of the protective effects of a herpes simplex virus 1 subunit vaccine (International Immunopharmacology (2002) 2:12 (1703-1711) DOI: 10.1016/S1567-5769(02)00192-3) 2005
    2004 Synthesis of mannopyranose disaccharides as photoaffinity probes for mannosyltransferases in Mycobacterium tuberculosis 2004
    2004 Antimycobacterial Agents. 1. Thio Analogues of Purine 2004
    2003 Arabinofuranose disaccharide analogs as inhibitors of Mycobacterium tuberculosis 2003
    2003 Fractionation, structural studies, and immunological characterization of the semi-synthetic Quillaja saponins derivative GPI-0100 2003
    2002 Synthesis of an arabinofuranosyl disaccharide photoaffinity probe for arabinosyltransferase activity in Mycobacterium tuberculosis 2002
    2002 Quillaja saponin adjuvants: Derivatives formed under sub-optimal conditions 2002
    2002 Studies on n-octyl-5-(α-D-arabinofuranosyl)-β-D-galactofuranosides for mycobacterial glycosyltransferase activity 2002
    2002 Degradation of Quillaja saponaria Molina saponins: Loss of the protective effects of a herpes simplex virus 1 subunit vaccine 2002
    2001 A facile method for deprotection of trityl ethers using column chromatography 2001
    2001 Altered immunomodulating and toxicological properties of degraded Quillaja saponaria Molina saponins 2001
    2001 Synthesis of a fluorescent arabinofuranosyl disaccharide: A probe for arabinosyltransferase activity in Mycobacterium tuberculosis 2001
    2001 Studies on (β,1→5) and (β,1→6) linked octyl Galf disaccharides as substrates for mycobacterial galactosyltransferase activity 2001
    2001 Studies on α(1→5) linked octyl arabinofuranosyl disaccharides for mycobacterial arabinosyl transferase activity 2001
    2000 Synthesis of disaccharides related to the mycobacterial arabinogalactan 2000
    2000 Development of semisynthetic triterpenoid saponin derivatives with immune stimulating activity 2000
    1999 Studies on β-D-Gal(f)-(1→4)-α-L-Rha(p) octyl analogues as substrates for mycobacterial galactosyl transferase activity 1999
    1998 Tin(IV) chloride mediated glycosylation in arabinofuranose, galactofuranose and rhamnopyranose 1998
    1997 Stereoselective epoxidation of acyclic allylic ethers using ketone-Oxone® system 1997
    1996 Studies on some Coordination Complexes of Bis(cyclopentadienyl)titanium(IV) Dichloride and Bis(cyclopentadienyl)zirconium(IV) Dichloride 1996
    1996 Nuclear magnetic resonance spectroscopic approaches for the determination of interglycosidic linkage and sequence in oligosaccharides 1996
    1995 Chemistry and biological activities of the genera Tinospora 1995
    1995 Chemistry and biological activities of the genera tinospora 1995
    1995 NMR spectroscopy of steroidal sapogenins and steroidal saponins: An update 1995
    1995 Synthesis, characterisation and reactions of some coordination compounds of trichloro(cyclopentadienyl)- titanium(IV) 1995
    1994 Deepoxidation of arteannuin b with chlorotrimethylsilane and sodium iodide 1994
    1994 Influence of skeletal alteration of lignoids on carbon‐13 NMR chemical shifts 1994
    1991 Reactions of bis{2,4-Diaminobenzo)sulphide and its complexes with diphenyltindichloride and tintetrachloride 1991
    1990 Studies on some oxozirconium(IV) and dioxouranium(VI) Schiff base complexes 1990
    1990 Some enzymatic changes at variable zinc in three Aspergillus species differing in zinc requirement 1990

    Research Overview

  • Keywords - Drug Design and Medicinal Chemistry in Infectious diseases, Carbohydrates, saponin adjuvants and drug delivery
  • Full Name

  • Ashish Pathak