Positions

Overview

  • Ashish Pathak, Ph.D., is an advanced research scientist in the Chemistry Department at Southern Research (SR), where he joined in 2009. His main research interests are medicinal chemistry approaches in the area of infectious diseases (anti-bacterials and anti-virals) and cancer, carbohydrates and saponins as immune stimulants, and vaccine adjuvants.

    Pathak received his doctorate in chemistry from University of Lucknow in Lucknow, India, in 1993. Subsequently, he completed post-doctoral studies at Central Institute of Medicinal Aromatic Plants, Lucknow, National Institute of Health Sciences, Tokyo, and SR in various aspects of phytochemistry, carbohydrates, and medicinal chemistry. He was assistant professor of organic chemistry at Western Illinois University in Macomb, Illinois, for four years prior to rejoining SR in 2009.

    Pathak is also an adjunct faculty in the Chemistry Department at the University of Alabama at Birmingham (UAB) and member of UAB’s Comprehensive Cancer Center.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2019 Synthesis of Aza-acyclic Nucleoside Libraries of Purine, Pyrimidine, and 1,2,4-TriazoleACS Combinatorial Science.  21:183-191. 2019
    2015 Benzimidazole analogs inhibit respiratory syncytial virus G protein functionAntiviral Research.  121:31-38. 2015
    2014 Unique functional and structural properties of the LRRK2 protein ATP-binding pocketJournal of Biological Chemistry.  289:32937-32951. 2014
    2014 Solution-phase parallel synthesis of acyclic nucleoside libraries of purine, pyrimidine, and triazole acetamidesACS Combinatorial Science.  16:485-493. 2014
    2013 6-Oxo and 6-thio purine analogs as antimycobacterial agentsBioorganic and Medicinal Chemistry.  21:1685-1695. 2013
    2012 Concise synthesis of an arabinofuranose hexasaccharide present in the cell wall of Mycobacterium tuberculosisTetrahedron Letters.  53:2461-2464. 2012
    2011 A high-throughput screening assay for inhibitors of bacterial motility identifies a novel inhibitor of the Na + -driven flagellar motor and virulence gene expression in Vibrio choleraeAntimicrobial Agents and Chemotherapy.  55:4134-4143. 2011
    2011 Lipoarabinomannan biosynthesis in Corynebacterineae: The interplay of two α(1→2)-mannopyranosyltransferases MptC and MptD in mannan branchingMicrobiological sciences.  80:1241-1259. 2011
    2011 Synthesis and antibacterial activity of ciprofloxacin derivativesResearch Journal of Pharmacy and Technology.  4:308-314. 2011
    2010 Antioxidant and anti-inflammatory potential of Pterospermum acerifoliumInternational journal of pharmaceutical sciences review and research.  2:1-5. 2010
    2009 Functional expression of Francisella tularensis FabH and FabI, potential antibacterial targetsProtein Expression and Purification.  65:83-91. 2009
    2009 Synthesis of deoxygenated α(1 → 5)-linked arabinofuranose disaccharides as substrates and inhibitors of arabinosyltransferases of Mycobacterium tuberculosisBioorganic and Medicinal Chemistry.  17:872-881. 2009
    2009 Imidazolium cation supported solution-phase assembly of homolinear α(1→6)-linked octamannoside: An efficient alternate approach for oligosaccharide synthesisJournal of Organic Chemistry.  74:6307-6310. 2009
    2008 Concise assembly of linear α(1→6)-linked octamannan fluorescent probeTetrahedron Letters.  49:7157-7160. 2008
    2008 Expression, purification and characterisation of soluble GlfT and the identification of a novel galactofuranosyltransferase Rv3782 involved in priming GlfT-mediated galactan polymerisation in Mycobacterium tuberculosisProtein Expression and Purification.  58:332-341. 2008
    2008 Oligomannan synthesis using ionic liquid supported glycosylationOrganic Letters.  10:145-148. 2008
    2007 Evaluation of CNS activities of aerial parts of Jasminum multiflorum Andr.Asian Journal of Chemistry.  19:4452-4458. 2007
    2007 Disaccharide analogs as probes for glycosyltransferases in Mycobacterium tuberculosisBioorganic and Medicinal Chemistry.  15:5629-5650. 2007
    2007 Synthesis of symmetrical C- and pseudo-symmetrical O-linked disaccharide analogs for arabinosyltransferase inhibitory activity in Mycobacterium tuberculosisBioorganic and Medicinal Chemistry Letters.  17:4527-4530. 2007
    2007 Evaluation of anthelmintic activity of leaves of Callistemon citrinus curtisAsian Journal of Chemistry.  19:2839-2842. 2007
    2007 Semi-synthesis of deoxyartemisininMendeleev Communications.  17:27-28. 2007
    2006 Novel conjugate of moxifloxacin and carboxymethylated glucan with enhanced activity against Mycobacterium tuberculosisAntimicrobial Agents and Chemotherapy.  50:1982-1988. 2006
    2005 Erratum: Degradation of Quillaja saponaria Molina saponins: Loss of the protective effects of a herpes simplex virus 1 subunit vaccine (International Immunopharmacology (2002) 2:12 (1703-1711) DOI: 10.1016/S1567-5769(02)00192-3)International Immunopharmacology.  5:1658. 2005
    2004 Synthesis of mannopyranose disaccharides as photoaffinity probes for mannosyltransferases in Mycobacterium tuberculosisCarbohydrate Research.  339:683-691. 2004
    2004 Antimycobacterial Agents. 1. Thio Analogues of PurineJournal of Medicinal Chemistry.  47:273-276. 2004
    2003 Arabinofuranose disaccharide analogs as inhibitors of Mycobacterium tuberculosisTetrahedron.  59:10239-10248. 2003
    2003 Fractionation, structural studies, and immunological characterization of the semi-synthetic Quillaja saponins derivative GPI-0100Vaccine.  21:3961-3971. 2003
    2002 Synthesis of an arabinofuranosyl disaccharide photoaffinity probe for arabinosyltransferase activity in Mycobacterium tuberculosisBioorganic and Medicinal Chemistry Letters.  12:2749-2752. 2002
    2002 Quillaja saponin adjuvants: Derivatives formed under sub-optimal conditionsVaccine.  20:3237-3238. 2002
    2002 Studies on n-octyl-5-(α-D-arabinofuranosyl)-β-D-galactofuranosides for mycobacterial glycosyltransferase activityBioorganic and Medicinal Chemistry.  10:923-928. 2002
    2002 Degradation of Quillaja saponaria Molina saponins: Loss of the protective effects of a herpes simplex virus 1 subunit vaccineInternational Immunopharmacology.  2:1703-1711. 2002
    2001 A facile method for deprotection of trityl ethers using column chromatographyTetrahedron Letters.  42:7755-7757. 2001
    2001 Altered immunomodulating and toxicological properties of degraded Quillaja saponaria Molina saponinsInternational Immunopharmacology.  1:813-818. 2001
    2001 Synthesis of a fluorescent arabinofuranosyl disaccharide: A probe for arabinosyltransferase activity in Mycobacterium tuberculosisTetrahedron Letters.  42:979-982. 2001
    2001 Studies on (β,1→5) and (β,1→6) linked octyl Galf disaccharides as substrates for mycobacterial galactosyltransferase activityBioorganic and Medicinal Chemistry.  9:3129-3143. 2001
    2001 Studies on α(1→5) linked octyl arabinofuranosyl disaccharides for mycobacterial arabinosyl transferase activityBioorganic and Medicinal Chemistry.  9:3145-3151. 2001
    2000 Synthesis of disaccharides related to the mycobacterial arabinogalactanCarbohydrate Letters.  4:117-122. 2000
    2000 Development of semisynthetic triterpenoid saponin derivatives with immune stimulating activityVaccine.  18:3141-3151. 2000
    1999 Studies on β-D-Gal(f)-(1→4)-α-L-Rha(p) octyl analogues as substrates for mycobacterial galactosyl transferase activityBioorganic and Medicinal Chemistry.  7:2407-2413. 1999
    1998 Tin(IV) chloride mediated glycosylation in arabinofuranose, galactofuranose and rhamnopyranoseTetrahedron Letters.  39:1497-1500. 1998
    1997 Stereoselective epoxidation of acyclic allylic ethers using ketone-Oxone® systemChemistry Letters.  1015-1016. 1997
    1996 Studies on some Coordination Complexes of Bis(cyclopentadienyl)titanium(IV) Dichloride and Bis(cyclopentadienyl)zirconium(IV) DichlorideJournal of the Indian Chemical Society.  73:227-232. 1996
    1996 Nuclear magnetic resonance spectroscopic approaches for the determination of interglycosidic linkage and sequence in oligosaccharidesPhytochemical Analysis.  7:113-130. 1996
    1995 Chemistry and biological activities of the genera TinosporaInternational Journal of Pharmacognosy.  33:277-287. 1995
    1995 Chemistry and biological activities of the genera tinosporaPharmaceutical Biology.  33:277-287. 1995
    1995 NMR spectroscopy of steroidal sapogenins and steroidal saponins: An updateMagnetic Resonance in Chemistry.  33:923-953. 1995
    1995 Synthesis, characterisation and reactions of some coordination compounds of trichloro(cyclopentadienyl)- titanium(IV)Synthesis and Reactivity in Inorganic and Metal Organic Chemistry.  25:163-181. 1995
    1994 Deepoxidation of arteannuin b with chlorotrimethylsilane and sodium iodideJournal of Natural Products.  57:1708-1710. 1994
    1994 Influence of skeletal alteration of lignoids on carbon‐13 NMR chemical shiftsMagnetic Resonance in Chemistry.  32:753-773. 1994
    1991 Reactions of bis{2,4-Diaminobenzo)sulphide and its complexes with diphenyltindichloride and tintetrachlorideSynthesis and Reactivity in Inorganic and Metal Organic Chemistry.  21:567-585. 1991
    1990 Studies on some oxozirconium(IV) and dioxouranium(VI) Schiff base complexesJournal of the Indian Chemical Society.  67:678-679. 1990
    1990 Some enzymatic changes at variable zinc in three Aspergillus species differing in zinc requirementMycological Research.  94:511-513. 1990

    Research Overview

  • Keywords - Drug Design and Medicinal Chemistry in Infectious diseases, Carbohydrates, saponin adjuvants and drug delivery
  • Education And Training

  • Doctor of Philosophy in Organic Chemistry, 1993
  • Full Name

  • Ashish Pathak