Overview

  • Dr. Faye-Petersen is an internationally recognized perinatal pathologist, author, and lecturer. She is a Past President of the Society for Pediatric Pathology (2016) and was the North American Councilor for the International Pediatric Pathology Association (2015-2018), the educational organization for specialty training in pediatric pathology in countries outside the US. She received her undergraduate (biology, chemistry, and philosophy) and medical degrees from the University of Colorado. She completed residency training at the Denver Presbyterian Hospital in Denver, CO, and later completed postdoctoral training in Surgical Pathology at the Memorial Sloan-Kettering Cancer Center and pediatric pathology at Mount Sinai Medical Center in New York City, NY. Since 1996, she has been cited in the annual publications of "Best Doctors in America." In February 2002, she was received the Society for Pediatric Pathology’s (SPP's) Distinguished Colleague Award. In 2005, Dr. Faye-Petersen established the first free-standing three-day multidisciplinary course in Perinatal Pathology, which she also directed in 2008 and 2015. This highly successful course has 100-140 participants and 12 international faculty and is aimed at pediatric and general pathology trainees and general practice pathologists. In March 2007, she was named the Outstanding Woman UAB Faculty Member for her academic, teaching, research, and community service contributions. In March 2011, Dr. Faye-Petersen was awarded the President's Scroll of Appreciation for her outstanding service to the SPP's educational efforts. Long committed to multidisciplinary education, Dr. Faye-Petersen has received numerous UAB School of Medicine teaching awards, and, in 2010, was one of two UAB School of Medicine faculty inducted into Alpha Omega Alpha National Honor Society. She personally funds an annual, unique, Multidisciplinary Teaching Award for trainees that requires the awardee be nominated by UAB medical students and pathology residents and fellows. One to two trainees have been awarded since 2012. Finally, she was instrumental in starting, and continues to remain active in the UAB Commission for the Status of Women's annual community clothing drive, "Suits for Success." This drive is the major contributor to the YWCA of North Central Alabama's resource, "My Sister's Closet," for interviewing and work attire, for economically disadvantaged women. This campus-wide UAB drive results in the annual collection of at least one to two tons of such clothing and accessories from UAB donors and the surrounding regional communities; April 2019 marked the 14th Annual UAB S4S drive.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2019 Hospital-acquired viral respiratory infections in neonates hospitalized since birth in a tertiary neonatal intensive care unit 2019
    2019 Travel History Is Important! A Case of Trypanosoma cruzi Identified by Placental Examination 2019
    2018 Ectopic Liver Within the Placental Parenchyma of a Stillborn Fetus 2018
    2018 Dichorionic Twins Discordant for Massive Perivillous Fibrinoid Deposition: Report of a Case and Review of the Literature 2018
    2017 Ureaplasma infection-mediated release of matrix metalloproteinase-9 and PGP: A novel mechanism of preterm rupture of membranes and chorioamnionitis 2017
    2016 Placental massive perivillous fibrinoid deposition associated with coxsackievirus A16-report of a case, and review of the literature 2016
    2016 Sampling and definitions of placental lesions Amsterdam placental workshop group consensus statement 2016
    2016 Regulation of alveolar septation by microRNA-489 2016
    2015 Alterations in gene expression and DNA methylation during murine and human lung alveolar septation 2015
    2015 Integrated genomic analyses in bronchopulmonary dysplasia 2015
    2015 Pathology of the stillborn infant for the general pathologist: Part 1 2015
    2015 Development of novel software to generate anthropometric norms at perinatal autopsy 2015
    2015 Pathology of the Stillborn Infant for the General Pathologist: Part 2 2015
    2014 Small patients, complex challenging cases: A reappraisal of the professional efforts in perinatal autopsies 2014
    2014 Trisomy 21-associated transient abnormal myelopoiesis involving the maternal space of the placenta: A case report and literature review 2014
    2013 Maternal Floor Infarction and Massive Perivillous Fibrin Deposition 2013
    2013 Placental Mesenchymal Dysplasia 2013
    2013 Effect of corticosteroid interval on markers of inflammation in spontaneous preterm birth 2013
    2013 Histological characteristics of the fetal inflammatory response associated with neurodevelopmental impairment and death in extremely preterm infants 2013
    2012 Elevated midtrimester α-fetoprotein and delivery markers of inflammation in a preterm population 2012
    2012 Intrauterine fetal death of a monochorionic twin with peripheral pulmonary infarcts: Potential thromboembolic events following death of co-twin 2012
    2012 OTX2 mutations contribute to the otocephaly-dysgnathia complex 2012
    2011 Differential gene expression in the adrenals of normal and anencephalic fetuses and studies focused on the fras-1-related extracellular matrix protein (FREM2) gene 2011
    2011 Hydroxysteroid sulfotransferase 2B1b expression and localization in normal human brain 2011
    2009 Handling of perinatal specimens: A society for pediatric pathology practice committee survey 2009
    2008 The placenta in preterm birth 2008
    2008 Chorioamnionitis and funisitis: Their implications for the neonate 2008
    2008 Demystifying the pathologic diagnoses of villitis and fetal thrombotic vasculopathy 2008
    2008 Mediastinal teratoma as a rare cause of hydrops fetalis and death: Report of 3 cases 2008
    2008 Twin-to-twin transfusion syndrome: Part 1. Types and pathogenesis 2008
    2008 Twin-to-twin transfusion syndrome: Part 2. Infant anomalies, clinical interventions, and placental examination 2008
    2008 Twin-to-twin transfusion: Part 3. Mortality and neurodevelopmental outcomes following intervention 2008
    2008 Early preterm birth: association between in utero exposure to acute inflammation and severe neurodevelopmental disability at 6 years of age 2008
    2008 The Alabama Preterm Birth Study: Umbilical cord blood Ureaplasma urealyticum and Mycoplasma hominis cultures in very preterm newborn infants 2008
    2007 The Alabama Preterm Birth Study: Diffuse decidual leukocytoclastic necrosis of the decidua basalis, a placental lesion associated with preeclampsia, indicated preterm birth and decreased fetal growth 2007
    2006 Pulmonary atresia with intact ventricular septum associated with congenitally corrected transposition 2006
    2006 The Alabama Preterm Birth Study: Intrauterine infection and placental histologic findings in preterm births of males and females less than 32 weeks 2006
    2006 The Alabama Preterm Birth Study: Corticosteroids and neonatal outcomes in 23- to 32-week newborns with various markers of intrauterine infection 2006
    2006 Otocephaly: Report of five new cases and a literature review 2006
    2006 The Alabama Preterm Birth Project: Placental histology in recurrent spontaneous and indicated preterm birth 2006
    2006 The Alabama Preterm Birth study: polymorphonuclear and mononuclear cell placental infiltrations, other markers of inflammation, and outcomes in 23- to 32-week preterm newborn infants 2006
    2006 Comparison of fetal and adult marrow stromal cells in osteogenesis with and without glucocorticoids 2006
    2005 Intrathoracic ectopic lobe of liver presenting as pulmonary sequestration 2005
    2004 Periodontal disease and upper genital tract inflammation in early spontaneous preterm birth 2004
    2003 Erratum: Amniotic Infection Syndrome: Nosology and Reproducibility of Placental Reaction Patterns (Pediatric and Developmental Pathology 6:4) 2003
    2003 Amniotic Infection Syndrome: Nosology and Reproducibility of Placental Reaction Patterns 2003
    2003 A little bit of everything: Molecular genetics of congenital hyperinsulinism 2003
    2001 Lethal pulmonary hypoplasia after in-utero myelomeningocele repair 2001
    2000 Infective pseudoaneurysm in a neonate 2000
    1999 Value of perinatal autopsy 1999
    1999 Fetal membrane histology in preterm premature rupture of membranes: Comparison to controls, and between antibiotic and placebo treatment 1999
    1998 Surrogate light chain production during B cell differentiation: Differential intracellular versus cell surface expression 1998
    1998 Effects of ACTH and cytokines on dehydroepiandrosterone sulfotransferase messenger RNA in human adrenal cells 1998
    1998 Two fetal deaths associated with maternal sepsis and with thrombosis of the intervillous space of the placenta 1998
    1997 Histologic features of chorioamnion membrane rupture: Development of methodology 1997
    1996 Prostaglandin E1-induced hyperostosis: Clinicopathologic correlations and possible pathogenetic mechanisms 1996
    1996 Stage-specific expression of integrin αvβ3 in neuroblastic tumors 1996
    1996 Lymphoplasmacytic aortitis and acute aortic dissection: An uncommon association 1996
    1995 Erratum: Immunocytochemical analyses of dehydroepiandrosterone sulfotransferase in cultured human fetal adrenal cells (Journal of Clinical Endocrinology and Metabolism (1995) 80 (1027-1031)) 1995
    1995 Immunocytochemical analyses of dehydroepiandrosterone sulfotransferase in cultured human fetal adrenal cells 1995
    1995 Immunohistochemical evaluation of the cellular localization and ontogeny of 3βhydroxysteroid dehydrogenase/delta 5-4 isomerase in the human fetal adrenal Gland 1995
    1994 Neurenteric cyst or teratomatous cyst [6] 1994
    1993 Coronary arterial patterns in double-outlet right ventricle 1993
    1993 Lumbosacral neurenteric cyst in an infant. Case report 1993
    1993 Radiologic-pathologic correlation: Capillary hemangioma of the meninges 1993
    1991 Giant cell vasculitis with extravascular granulomas in an adolescent 1991
    1991 Leukemic relapse presenting with ureteral obstruction caused by granulocytic sarcoma 1991
    1991 Neural Arch Stenosis and Spinal Cord Injury in Thanatophoric Dysplasia 1991
    1991 Osteochondrodysplasia with rhizomelia, platyspondyly, callosal agenesis, thrombocytopenia, hydrocephalus, and hypertension 1991
    1990 Cystic and solid heterotopic brain in the face and neck: A review and report of an unusual case 1990

    Chapter

    Year Title Altmetric
    2014 Human Placental Development from Conception to Term.  2322-2341. 2014
    2014 Miscellaneous Placental Pathology (Includes Massive Perivillous Fibrin Deposition, Fetal Thrombotic Vasculopathy, and Placenta Accreta).  2403-2422. 2014

    Research Overview

  • Dr. Faye-Petersen's service responsibilities and areas of research activities are largely focused on perinatal and placental pathology. Through the combined support of the Department of Pathology and UAB Hospital, in 1995, she established a diagnostic regional referral service laboratory for embryo-fetal and placental pathology, the UAB Microdissectional Laboratory (MDL). From 7/1995 through 1/2009, the MDL provided in-depth multidisciplinary evaluations of conceptus specimens delivered from women with histories of recurrent, spontaneous abortion; fetuses and placentas from pregnancies with antenatally documented or suspected abnormalities and genetic syndromes; cases of intrauterine fetal demise; and placentas from stillborn or live born infants whose gestations were complicated by maternal disease or other adverse factors. In 2/2009, the outreach autopsy aspect of the MDL was discontinued, due to financial constraints. However, in late 2009, the need for such evaluations was addressed through its addition the outreach services of the UAB Autopsy Service, where Dr Faye-Petersen continues to perform postmortem examinations of stillborns and cases of infant death. MDL placental evaluations have continued to provide UAB and community obstetricians with pathologic correlations for prenatal clinical and ultrasonographic diagnoses, and have helped to answer questions concerning the causes of pregnancy loss, fetal growth restriction and maldevelopment, and neonatal complications. The MDL examinations also provide information essential for meaningful medical genetics counseling, grief counseling for patients and their families, and clinicopathologic correlations useful to future care of obstetrical and infant patients. MDL and UAB Autopsy Pathology Service work has enabled Dr Faye-Petersen to participate in several NIH-funded clinical research studies and collaborative studies with other placental pathologists to elucidate which placental pathologic findings may correlate with increased risks for perinatal morbidity and mortality, or underlying maternal disorders. Recent collaborations include investigation of the transplacental passage of cytomegalovirus infection, the placental microbiome in normal and abnormal gestations,and epigenetic factors involved in development of bronchopulmonary dysplasia. In addition to her role as UAB's perinatal pathologist, Dr. Faye-Petersen is also the primary autopsy pathologist for cases complicated by congenital cardiovascular malformations. In 1997, she, with aid of two colleagues, completed a re-examination and registry of UAB's cases of congenital heart disease. As primary investigator of this aspect of the UAB Congenital Heart Disease Program (CHDP), she established a formal, centralized site for the ongoing collection of formalin-fixed specimens with congenital heart malformations (some 650 to date) to support multidisciplinary education and research in the pathology and pathogenesis of cardiovascular malformations.

    Keywords - perinatal pathology, congenital cardiovascular malformations
  • Education And Training

  • Presbyterian/St. Luke's Medical Center, Internship 1982
  • Presbyterian/St. Luke's Medical Center, Residency 1985
  • Mount Sinai Hospital, Postdoctoral Fellowship 1987
  • Memorial Sloan-Kettering Guttman Diagnostic Center, Postdoctoral Fellowship 1986
  • Full Name

  • Ona Faye-Petersen