Selected Publications

Academic Article

Year Title Altmetric
2019 Biodistribution of adeno-associated virus type 2 with mutations in the capsid that contribute to heparan sulfate proteoglycan binding 2019
2018 The Lipase Activity of Phospholipase D2 is Responsible for Nigral Neurodegeneration in a Rat Model of Parkinson's Disease 2018
2017 Neurodegeneration: Keeping ATF4 on a tight leash 2017
2016 Up-regulation of activating transcription factor 4 induces severe loss of dopamine nigral neurons in a rat model of Parkinson's disease 2016
2016 Neuronatin is a stress-responsive protein of rod photoreceptors 2016
2016 Limited ATF4 expression in degenerating retinas with ongoing ER stress promotes photoreceptor survival in a mouse model of autosomal dominant retinitis pigmentosa 2016
2015 Unfolded protein response is activated in aged retinas 2015
2015 The loss of glucose-regulated protein 78 (GRP78) during normal aging or from siRNA knockdown augments human alpha-synuclein (α-syn) toxicity to rat nigral neurons 2015
2014 Modulation of the rate of retinal degeneration in T17M RHO mice by reprogramming the unfolded protein response. 2014
2013 Salivary peptide tyrosine-tyrosine 3-36 modulates ingestive behavior without inducing taste aversion 2013
2013 Review: Retinal degeneration: Focus on the unfolded protein response 2013
2013 Improved Adeno-associated Viral Gene Transfer to Murine Glioma. 2013
2013 The Molecular Chaperone GRP78/BiP as a Therapeutic Target for Neurodegenerative Disorders: A Mini Review. 2013
2013 Caspase-7 ablation modulates UPR, reprograms TRAF2-JNK apoptosis and protects T17M rhodopsin mice from severe retinal degeneration 2013
2012 ER stress is involved in T17M rhodopsin-induced retinal degeneration 2012
2012 Functional rescue of P23H rhodopsin photoreceptors by gene delivery 2012
2012 Glucose regulated protein 78 diminishes α-synuclein neurotoxicity in a rat model of parkinson disease 2012
2011 Salivary PYY: A putative bypass to satiety 2011
2010 In Vivo RNAi-Mediated α-Synuclein Silencing Induces Nigrostriatal Degeneration. 2010
2010 Restoration of visual function in P23H rhodopsin transgenic rats by gene delivery of BiP/Grp78 2010
2010 In vivo RNAi-mediated α-synuclein silencing induces nigrostriatal degeneration 2010
2010 α-synuclein expression in rat substantia nigra suppresses phospholipase D2 toxicity and nigral neurodegeneration 2010
2009 Nigrostriatal rAAV-mediated GDNF overexpression induces robust weight loss in a rat model of age-related obesity 2009
2009 Weight Loss in Obese Leptin-Resistant Rats Induced by Activation of CRH Neurons in the Paraventricular Nucleus of the Hypothalamus by Overexpression of Substantial Nigral-Injected rAAV5-GDNF 2009
2008 The phosphorylation state of Ser-129 in human α-synuclein determines neurodegeneration in a rat model of Parkinson disease 2008
2006 Molecular mechanism of the constitutive activation of the L250Q human melanocortin-4 receptor polymorphism 2006
2004 Recombinant AAV viral vectors pseudotyped with viral capsids from serotypes 1, 2, and 5 display differential efficiency and cell tropism after delivery to different regions of the central nervous system 2004
2004 Adeno-associated virus type 2 VP2 capsid protein is nonessential and can tolerate large peptide insertions at its N terminus 2004
2004 Adaptation of baculovirus system for large-scale production of rAAV vector serotypes 2004
2004 Differential modulation of energy balance by leptin, ciliary neurotrophic factor, and leukemia inhibitory factor gene delivery: Microarray deoxyribonucleic acid-chip analysis of gene expression 2004
2002 Evidence for endogenous agmatine in hypothalamo-neurohypophysial tract and its modulation on vasopressin release and Ca2+ channels 2002
2001 Localization of agmatine in vasopressin and oxytocin neurons of the rat hypothalamic paraventricular and supraoptic nuclei 2001
2000 Agmatine is an autocrine/paracrine inhibitor of pre-synaptic Ca plus plus channels and vasopressin release in vasopressinergic neurons of the hypothalamo-hypophyseal tract 2000
2000 Agmatine may be an autocrine/paracrine blocker of Ca channels in neurohypophysail vasopressinergic terminals via imidazoline receptors. 2000
2000 Effect of 2-mercaptoacetate and 2-deoxy-D-glucose administration on the expression of NPY, AGRP, POMC, MCH and hypocretin/orexin in the rat hypothalamus 2000
1999 Some Current Approuches in Studying the Rat Hypothalamic Structures Influenced by Earthly Correlates of Micro- and Macrogravity 1999
1998 Effect of inhibition of glucose and fat metabolism on galanin-R1 receptor mRNA levels in the rat hypothalamic paraventricular and supraoptic nuclei 1998
1998 Effects of antimetabolites to glucose and fatty acids on galanin-1 receptor mRNA levels in the hypothalamic paraventricular and supraoptic nuclei 1998
1998 Nitric oxide in paraventricular nuclei of rat hypothalamus under extreme conditions 1998
1997 Developmental expression of nitric oxide synthase in the rat diencephalon with special reference to the thalamic paratenial nucleus 1997
1996 Reaction of the paraventricular nucleus of the hypothalamus and the dorsal nucleus of the vagus of rats to change in the gravitational environment 1996
1991 Metabolism of testosterone in discrete regions of the brain of rat embryos 1991
1989 Response of single cell populations of the paraventricular hypothalamic nuclei to carbohydrate loading and starvation in rats 1989
1989 Aromatase activity in some areas of rat foetus brain 1989
1989 The compensation of experimental diabetes in rats by means of the transplantation of embryonal pancreatic gland into the anterior chamber of the eye 1989

Education And Training

  • Doctor of Philosophy in Medical Basic Sciences, 1991
  • Full Name

  • Oleg Gorbatyuk