Selected Publications

Academic Article

Year Title Altmetric
2020 The origin of NMDA receptor hypofunction in schizophreniaPharmacology and Therapeutics.  205. 2020
2019 Schizophrenia-like dopamine release abnormalities in a mouse model of NMDA receptor hypofunctionSchizophrenia Bulletin.  45:138-147. 2019
2018 AMPA Receptor Activation–Independent Antidepressant Actions of Ketamine Metabolite (S)-NorketamineBiological Psychiatry.  84:591-600. 2018
2018 Neuropsychiatric Phenotypes Produced by GABA Reduction in Mouse Cortex and HippocampusNeuropsychopharmacology.  43:1445-1456. 2018
2017 Spatial and temporal boundaries of NMDA receptor hypofunction leading to schizophrenianpj Schizophrenia.  3. 2017
2017 Electrophysiological evidence for defective fast-spiking GABAergic neurones in a schizophrenia model 2017
2017 Erratum: Dentate Mossy Cell and Pattern Separation (Neuron (2017) 93(3) (465–467) (S0896627317300454) (10.1016/j.neuron.2017.01.021))Neuron.  93:1236. 2017
2017 Dentate Mossy Cell and Pattern SeparationNeuron.  93:465-467. 2017
2017 Reduced ethanol drinking following selective cortical interneuron deletion of the GluN2B NMDA receptors subunitAlcohol.  58:47-51. 2017
2015 Cortical GluN2B deletion attenuates punished suppression of food reward-seekingPsychopharmacology.  232:3753-3761. 2015
2015 NMDA receptor subunits and associated signaling molecules mediating antidepressant-related effects of NMDA-GluN2B antagonismBehavioural Brain Research.  287:89-95. 2015
2015 Impaired discrimination learning in interneuronal NMDAR-GluN2B mutant miceNeuroReport.  26:489-494. 2015
2014 Dysregulation of the axonal trafficking of nuclear-encoded mitochondrial mRNA alters neuronal mitochondrial activity and mouse behavior 2014
2014 Brain state-dependent abnormal LFP activity in the auditory cortex of a schizophrenia mouse modelFrontiers in Neuroscience2014
2013 Identification of transcription factors for lineage-specific ESC differentiationStem Cell Reports.  1:545-559. 2013
2013 Convergence of genetic and environmental factors on parvalbumin-positive interneurons in schizophreniaFrontiers in Behavioral Neuroscience2013
2013 GluN2B in corticostriatal circuits governs choice learning and choice shiftingNature Neuroscience.  16:1101-1110. 2013
2013 Social isolation exacerbates schizophrenia-like phenotypes via oxidative stress in cortical interneuronsBiological Psychiatry.  73:1024-1034. 2013
2013 Contribution of NMDA Receptor Hypofunction in Prefrontal and Cortical Excitatory Neurons to Schizophrenia-Like PhenotypesPLoS ONE.  8. 2013
2013 Hilar mossy cell circuitry controlling dentate granule cell excitabilityFrontiers in Neural Circuits2013
2013 Preferential inactivation of SCN1A in parvalbumin interneurons increases seizure susceptibilityNeurobiology of Disease.  49:211-220. 2013
2012 Hilar Mossy Cell Degeneration Causes Transient Dentate Granule Cell Hyperexcitability and Impaired Pattern SeparationNeuron.  76:1189-1200. 2012
2012 Acute d-serine treatment produces antidepressant-like effects in rodentsInternational Journal of Neuropsychopharmacology.  15:1135-1148. 2012
2012 GABAergic interneuron origin of schizophrenia pathophysiologyNeuropharmacology.  62:1574-1583. 2012
2011 Genetically engineered mice for schizophrenia researchNeuromethods.  59:231-242. 2011
2011 Chronic stress-induced hippocampal dendritic retraction requires CA3 NMDA receptorsNeuroscience.  174:26-36. 2011
2010 Loss of GluN2B-containing NMD A receptors in CA1 hippocampus and cortex impairs long-term depression, reduces dendritic spine density, and disrupts learning 2010
2010 eIF2α phosphorylation-dependent translation in CA1 pyramidal cells impairs hippocampal memory consolidation without affecting general translation 2010
2010 Postnatal NMDA receptor ablation in corticolimbic interneurons confers schizophrenia-like phenotypesNature Neuroscience.  13:76-83. 2010
2009 Lack of kainic acid-induced gamma oscillations predicts subsequent CA1 excitotoxic cell deathEuropean Journal of Neuroscience.  30:1036-1055. 2009
2009 Chemically inducible inactivation of protein synthesis in genetically targeted neurons 2009
2008 Notch1 signaling in pyramidal neurons regulates synaptic connectivity and experience-dependent modifications of acuity in the visual cortex 2008
2006 CA3 NMDA receptors are crucial for rapid and automatic representation of context memoryEuropean Journal of Neuroscience.  24:1771-1780. 2006
2006 Inducible and Cell-Type Restricted Manipulation in the Entorhinal CortexNeuron.  50:183-185. 2006
2006 Hippocampal CA3 NMDA receptors are crucial for adaptive timing of trace eyeblink conditioned response 2006
2004 NMDA receptors, place cells and hippocampal spatial memoryNature Reviews Neuroscience.  5:361-372. 2004
2003 Erratum: NMDA receptor-dependent ocular dominance plasticity in adult visual cortex (Neuron (June 19, 2003) 38 (977-985))Neuron.  39:727. 2003
2003 NMDA receptor-dependent ocular dominance plasticity in adult visual cortexNeuron.  38:977-985. 2003
2003 Genetic neuroscience of mammalian learning and memory 2003
2003 Hippocampal CA3 NMDA receptors are crucial for memory acquisition of one-time experienceNeuron.  38:305-315. 2003
2003 Essential function of α-calcium/calmodulin-dependent protein kinase II in neurotransmitter release at a glutamatergic central synapse 2003
2002 Requirement for hippocampal CA3 NMDA receptors in associative memory recallScience.  297:211-218. 2002
1997 Persistent phosphorylation parallels long-term desensitization of cerebellar purkinje cell AMPA-type glutamate receptorsLearning and Memory.  3:578-591. 1997
1995 Antibody specific for phosphorylated AMPA-type glutamate receptors at GluR2 Ser-696Neuroscience Research.  24:75-86. 1995
1995 Immunohistochemical localization of protein phosphatase isoforms in the rat cerebellumNeuroscience Research.  22:133-136. 1995
1995 Transient and persistent phosphorylation of AMPA-type glutamate receptor subunits in cerebellar Purkinje cellsNeuron.  15:697-709. 1995
1994 Ganglioside G(D1α) in cerebellar Purkinje cells: Its specific absence in mouse mutants with Purkinje cell abnormality and altered immunoreactivity in response tc conjunctive stimuli causing long term desensitizationJournal of Biological Chemistry.  269:32418-32425. 1994
1993 The conjunctive stimuli that cause long-term desensitization also predominantly induce c-fos and jun-B in cerebellar purkinje cellsNeuroReport.  4:1275-1278. 1993
1993 Kinetic study of human β- 1,4-galactosyltrasgerase expressed in E.coliJournal of Biochemistry.  113:747-753. 1993
1991 Characterization of a murine β1‐4galactosyltransferase expressed in COS‐1 cells 1991
1988 Cloning and sequencing of a full-length cDNA of mouse N-acetylglucosamine (β1-4)galactosyltransferaseJournal of Biochemistry.  104:165-168. 1988


Year Title Altmetric
2008 On crucial roles of hippocampal NMDA receptors in acquisition and recall of associative memory.  326-356. 2008

Education And Training

  • Doctor of Philosophy in Biology / Biological Sciences, Keio University 1991
  • Doctor of Medicine, Keio University 1987
  • Full Name

  • Kazutoshi Nakazawa