Positions

Selected Publications

Academic Article

Year Title Altmetric
2019 GPx3 supports ovarian cancer progression by manipulating the extracellular redox environmentRedox Biology.  25. 2019
2019 Context-dependent activation of SIRT3 is necessary for anchorage-independent survival and metastasis of ovarian cancer cellsOncogene2019
2018 CDK8 selectively promotes the growth of colon cancer metastases in the liver by regulating gene expression of TIMP3 and matrix metalloproteinasesCancer Research.  78:6594-6606. 2018
2018 TAK1 activation of alpha-TAT1 and microtubule hyperacetylation control AKT signaling and cell growthNature Communications.  9. 2018
2018 Mediator kinase CDK8/CDK19 drives YAP1-dependent BMP4-induced EMT in cancerOncogene.  37:4792-4808. 2018
2018 Inhibin is a novel paracrine factor for tumor angiogenesis and metastasisCancer Research.  78:2978-2989. 2018
2018 Dually modified transmembrane proteoglycans in development and diseaseCytokine and Growth Factor Reviews.  39:124-136. 2018
2017 Insights into the dichotomous regulation of SOD2 in cancerAntioxidants.  6. 2017
2017 TGF-β triggers rapid fibrillogenesis via a novel TβRII-dependent fibronectin-trafficking mechanismCell regulation.  28:1195-1207. 2017
2017 Angiostatic actions of capsicodendrin through selective inhibition of VEGFR2-mediated AKT signaling and disregulated autophagyOncotarget.  8:12675-12685. 2017
2016 Altering the proteoglycan state of transforming growth factor β type III receptor (TβRIII)/betaglycan modulates canonical Wnt/β-catenin signalingJournal of Biological Chemistry.  291:25716-25728. 2016
2016 Activation of Mitofusin2 by Smad2-RIN1 Complex during Mitochondrial FusionMolecular Cell.  62:520-531. 2016
2015 Endoglin regulation of Smad2 function mediates beclin1 expression and endothelial autophagyJournal of Biological Chemistry.  290:14884-14892. 2015
2015 Epigenetic Regulation of GDF2 Suppresses Anoikis in Ovarian and Breast EpitheliaNeoplasia : An International Journal for Oncology Research.  17:826-838. 2015
2014 Src-mediated post-translational regulation of endoglin stability and function is critical for angiogenesisJournal of Biological Chemistry.  289:25486-25496. 2014
2014 TGF-β regulates LARG and GEF-H1 during EMT to affect stiffening response to force and cell invasionCell regulation.  25:3528-3540. 2014
2013 Type III TGF-β receptor promotes FGF2-mediated neuronal differentiation in neuroblastomaJournal of Clinical Investigation.  123:4786-4798. 2013
2013 The type III TGFβ receptor regulates filopodia formation via a Cdc42-mediated IRSp53-N-WASP interaction in epithelial cellsBiochemical Journal.  454:79-89. 2013
2013 TβRIII/β-arrestin2 regulates integrin α5β1 trafficking, function, and localization in epithelial cellsOncogene.  32:1416-1427. 2013
2012 Endoglin mediates fibronectin/α5β1 integrin and TGF-β pathway crosstalk in endothelial cellsEMBO Journal.  31:3885-3900. 2012
2012 Endoglin inhibits ERK-induced c-Myc and cyclin D1 expression to impede endothelial cell proliferationBiochemical and Biophysical Research Communications.  424:620-623. 2012
2011 Mechanical Stiffness grades metastatic potential in patient tumor cells and in cancer cell linesCancer Research.  71:5075-5080. 2011
2011 The type III transforming growth factor-β receptor inhibits proliferation, migration, and adhesion in human myeloma cellsCell regulation.  22:1463-1472. 2011
2009 Proteoglycan signaling co-receptors: Roles in cell adhesion, migration and invasionCellular Signalling.  21:1548-1558. 2009
2009 The type III TGFβ receptor regulates directional migration: New tricks for an old dogCell Cycle.  8:3069-3070. 2009
2009 The type III TGF-β receptor regulates epithelial and cancer cell migration through β-arrestin2-mediated activation of Cdc42Proceedings of the National Academy of Sciences.  106:8221-8226. 2009
2008 ApoA-I induced CD31 in bone marrow-derived vascular progenitor cells increases adhesion: Implications for vascular repairBiochimica et Biophysica Acta Molecular and Cell Biology of Lipids.  1781:703-709. 2008
2008 The microtubule-based motor Kar3 and plus end-binding protein Bim1 provide structural support for the anaphase spindleJournal of Cell Biology.  180:91-100. 2008
2006 Reactive oxygen species in vascular endothelial cell motility. Roles of NAD(P)H oxidase and Rac1Cardiovascular Research.  71:236-246. 2006
2003 Differential kinetochore protein requirements for establishment versus propagation of centromere activity in Saccharomyces cerevisiaeJournal of Cell Biology.  160:833-843. 2003

Chapter

Year Title Altmetric
2013 Emerging roles of TGF-β co-receptors in human disease.  59-89. 2013

Education And Training

  • Doctor of Philosophy, University of North Carolina at Chapel Hill 2005
  • Master of Science in Medical Biochemistry, Hamdard University 1998
  • Bachelor of Science or Mathematics in Medical Biochemistry, University of Delhi 1996
  • Full Name

  • Mythreye Karthikeyan