Positions

Selected Publications

Academic Article

Year Title Altmetric
2020 Adolescent psychosocial stress enhances sensitization to cocaine exposure in genetically vulnerable miceNeuroscience Research.  151:38-45. 2020
2020 Assessing Reality Testing in Mice Through Dopamine-Dependent Associatively Evoked Processing of Absent Gustatory StimuliSchizophrenia Bulletin.  46:54-67. 2020
2020 Host–parasite interaction associated with major mental illnessMolecular Psychiatry.  25:194-205. 2020
2019 The transcriptome landscape associated with Disrupted-in-Schizophrenia-1 locus impairment in early development and adulthoodSchizophrenia Research.  210:149-156. 2019
2018 Translocator protein (TSPO) and stress cascades in mouse models of psychosis with inflammatory disturbancesSchizophrenia Research.  197:492-497. 2018
2018 Developmental trajectories of brain maturation and behavior: Relevance to major mental illnessesJournal of Pharmacological Sciences.  137:1-4. 2018
2018 Ulk2 controls cortical excitatory-inhibitory balance via autophagic regulation of p62 and GABAA receptor trafficking in pyramidal neuronsHuman Molecular Genetics.  27:3165-3176. 2018
2017 Behavioral changes in mice lacking interleukin-33eNeuro.  4. 2017
2017 Adolescent stress leads to glutamatergic disturbance through dopaminergic abnormalities in the prefrontal cortex of genetically vulnerable micePsychopharmacology.  234:3055-3074. 2017
2017 The involvement of brain-derived neurotrophic factor in 3,4-methylenedioxymethamphetamine-induced place preference and behavioral sensitizationBehavioural Brain Research.  329:157-165. 2017
2017 BDNF overexpression prevents cognitive deficit elicited by adolescent cannabis exposure and host susceptibility interactionHuman Molecular Genetics.  26:2462-2471. 2017
2016 DISC1 a key molecular lead in psychiatry and neurodevelopment: No-More Disrupted-in-Schizophrenia 1Molecular Psychiatry.  21:1488-1489. 2016
2016 A critical period of vulnerability to adolescent stress: Epigenetic mediators in mesocortical dopaminergic neuronsHuman Molecular Genetics.  25:1370-1381. 2016
2015 Interneuronal DISC1 regulates NRG1-ErbB4 signalling and excitatory-inhibitory synapse formation in the mature cortexNature Communications.  6. 2015
2015 Selective CNS Uptake of the GCP-II Inhibitor 2-PMPA following Intranasal AdministrationPLoS ONE.  10:e0131861. 2015
2013 Subcortical dopaminergic deficits in a DISC1 mutant model: A study in direct reference to human molecular brain imagingHuman Molecular Genetics.  22:1574-1580. 2013
2013 Adolescent stress-induced epigenetic control of dopaminergic neurons via glucocorticoidsScience.  339:335-339. 2013
2012 Mouse strain differences in phencyclidine-induced behavioural changesInternational Journal of Neuropsychopharmacology.  15:767-779. 2012
2012 Vulnerability in early life to changes in the rearing environment plays a crucial role in the aetiopathology of psychiatric disordersJapanese Journal of Psychopharmacology.  32:109-111. 2012
2011 Altered MHC class I expression in dorsolateral prefrontal cortex of nonsmoker patients with schizophreniaNeuroscience Research.  71:289-293. 2011
2011 Vulnerability in early life to changes in the rearing environment plays a crucial role in the aetiopathology of psychiatric disordersInternational Journal of Neuropsychopharmacology.  14:459-477. 2011
2011 Roles of a novel molecule 'shati' in the development of methamphetamine-induced dependenceCurrent Neuropharmacology.  9:104-108. 2011
2010 Enhanced dopamine function in DISC1-L100P mutant mice: Implications for schizophreniaGenes, Brain and Behavior.  9:777-789. 2010
2010 Oral supplementation with Leu-Ile, a hydrophobic dipeptide, prevents the impairment of memory induced by amyloid beta in mice via restraining the hyperphosphorylation of extracellular signal-regulated kinaseBehavioural Brain Research.  210:184-190. 2010
2010 Usp46, encoding a ubiquitin specific peptidase, is a quantitative trait gene underlying "behavioral despair" in miceSleep and Biological Rhythms.  8:114-119. 2010
2010 Silibinin attenuates cognitive deficits and decreases of dopamine and serotonin induced by repeated methamphetamine treatmentBehavioural Brain Research.  207:387-393. 2010
2010 Knockdown of DISC1 by In Utero Gene Transfer Disturbs Postnatal Dopaminergic Maturation in the Frontal Cortex and Leads to Adult Behavioral DeficitsNeuron.  65:480-489. 2010
2010 Combined effect of neonatal immune activation and mutant DISC1 on phenotypic changes in adulthoodBehavioural Brain Research.  206:32-37. 2010
2009 Silibinin attenuates amyloid β25-35 peptide-induced memory impairments: Implication of inducible nitric-oxide synthase and tumor necrosis factor-α in miceJournal of Pharmacology and Experimental Therapeutics.  331:319-326. 2009
2009 Usp46 is a quantitative trait gene regulating mouse immobile behavior in the tail suspension and forced swimming testsNature Genetics.  41:688-695. 2009
2009 The long-lasting effects of cross-fostering on the emotional behavior in ICR miceBehavioural Brain Research.  198:172-178. 2009
2008 A novel molecule 'shati' increases dopamine uptake via the induction of tumor necrosis factor-α in pheochromocytoma-12 cellsJournal of Neurochemistry.  107:1697-1708. 2008
2008 Identification of Piccolo as a regulator of behavioral plasticity and dopamine transporter internalizationMolecular Psychiatry.  13:451-463. 2008
2008 Piccolo regulates dopamine transporter internalization via PIP2Molecular Psychiatry.  13:349. 2008
2008 Genes and molecules that can potentiate or attenuate psychostimulant dependence: Relevance of data from animal models to human addictionAnnals of the New York Academy of Sciences.  1141:76-95. 2008
2007 Tumor Necrosis Factor-α and Its Inducer Inhibit Morphine-Induced Rewarding Effects and SensitizationBiological Psychiatry.  62:658-668. 2007
2007 Role of matrix metalloproteinase and tissue inhibitor of MMP in methamphetamine-induced behavioral sensitization and reward: Implications for dopamine receptor down-regulation and dopamine releaseJournal of Neurochemistry.  102:1548-1560. 2007
2007 A novel molecule "shati" is involved in methamphetamine-induced hyperlocomotion, sensitization, and conditioned place preferenceJournal of Neuroscience.  27:7604-7615. 2007
2007 Enduring vulnerability to reinstatement of methamphetamine-seeking behavior in glial cell line-derived neurotrophic factor mutant miceFederation proceedings.  21:1994-2004. 2007
2007 The roles of glial cell line-derived neurotrophic factor, tumor necrosis factor-α, and an inducer of these factors in drug dependenceJournal of Pharmacological Sciences.  104:116-121. 2007
2007 Involvement of glial cell line-derived neurotrophic factor in inhibitory effects of a hydrophobic dipeptide Leu-Ile on morphine-induced sensitization and rewarding effectsBehavioural Brain Research.  179:167-171. 2007
2007 An Inducer for Glial Cell Line-Derived Neurotrophic Factor and Tumor Necrosis Factor-α Protects Against Methamphetamine-Induced Rewarding Effects and SensitizationBiological Psychiatry.  61:890-901. 2007
2007 Reduction of methamphetamine-induced sensitization and reward in matrix metalloproteinase-2 and -9-deficient miceJournal of Neurochemistry.  100:1579-1588. 2007

Education And Training

  • Doctor of Philosophy in Neuropharmacology, Nagoya University 2007
  • Master of Science in Pharmaceutical Sciences, Chiba University 2003
  • Bachelor of Science or Mathematics in Pharmacy, Tokyo University of Pharmacy and Life Sciences 2001
  • Full Name

  • Minae Niwa
  • Blazerid

  • mniwa