Positions

Selected Publications

Academic Article

Year Title Altmetric
2021 Increased novelty-induced locomotion, sensitivity to amphetamine, and extracellular dopamine in striatum of Zdhhc15-deficient miceTranslational Psychiatry.  11. 2021
2020 Adolescent psychosocial stress enhances sensitization to cocaine exposure in genetically vulnerable miceNeuroscience Research.  151:38-45. 2020
2020 Assessing Reality Testing in Mice through Dopamine-Dependent Associatively Evoked Processing of Absent Gustatory StimuliSchizophrenia Bulletin.  46:54-67. 2020
2020 From population to neuron: exploring common mediators for metabolic problems and mental illnessesMolecular Psychiatry2020
2020 Host–parasite interaction associated with major mental illnessMolecular Psychiatry.  25:194-205. 2020
2019 The transcriptome landscape associated with Disrupted-in-Schizophrenia-1 locus impairment in early development and adulthoodSchizophrenia Research.  210:149-156. 2019
2018 Ulk2 controls cortical excitatory-inhibitory balance via autophagic regulation of p62 and GABAA receptor trafficking in pyramidal neuronsHuman Molecular Genetics.  27:3165-3176. 2018
2018 Translocator protein (TSPO) and stress cascades in mouse models of psychosis with inflammatory disturbancesSchizophrenia Research.  197:492-497. 2018
2018 Developmental trajectories of brain maturation and behavior: Relevance to major mental illnessesJournal of Pharmacological Sciences.  137:1-4. 2018
2017 Behavioral changes in mice lacking interleukin-33eNeuro.  4. 2017
2017 Adolescent stress leads to glutamatergic disturbance through dopaminergic abnormalities in the prefrontal cortex of genetically vulnerable micePsychopharmacology.  234:3055-3074. 2017
2017 BDNF overexpression prevents cognitive deficit elicited by adolescent cannabis exposure and host susceptibility interactionHuman Molecular Genetics.  26:2462-2471. 2017
2017 The involvement of brain-derived neurotrophic factor in 3,4-methylenedioxymethamphetamine-induced place preference and behavioral sensitizationBehavioural Brain Research.  329:157-165. 2017
2016 DISC1 a key molecular lead in psychiatry and neurodevelopment: No-More Disrupted-in-Schizophrenia 1Molecular Psychiatry.  21:1488-1489. 2016
2016 Dopamine D2L Receptor Is Required for Visual Discrimination and Reversal Learning. 2016
2016 A critical period of vulnerability to adolescent stress: Epigenetic mediators in mesocortical dopaminergic neuronsHuman Molecular Genetics.  25:1370-1381. 2016
2015 Interneuronal DISC1 regulates NRG1-ErbB4 signalling and excitatory-inhibitory synapse formation in the mature cortexNature Communications.  6. 2015
2015 Sequence of Molecular Events during the Maturation of the Developing Mouse Prefrontal Cortex. 2015
2015 Selective CNS Uptake of the GCP-II Inhibitor 2-PMPA following Intranasal AdministrationPLoS ONE.  10:e0131861. 2015
2013 Subcortical dopaminergic deficits in a DISC1 mutant model: A study in direct reference to human molecular brain imagingHuman Molecular Genetics.  22:1574-1580. 2013
2013 Adolescent stress-induced epigenetic control of dopaminergic neurons via glucocorticoidsScience.  339:335-339. 2013
2012 Mouse strain differences in phencyclidine-induced behavioural changesInternational Journal of Neuropsychopharmacology.  15:767-779. 2012
2012 Vulnerability in early life to changes in the rearing environment plays a crucial role in the aetiopathology of psychiatric disorders 2012
2011 Altered MHC class I expression in dorsolateral prefrontal cortex of nonsmoker patients with schizophreniaNeuroscience Research.  71:289-293. 2011
2011 Vulnerability in early life to changes in the rearing environment plays a crucial role in the aetiopathology of psychiatric disordersInternational Journal of Neuropsychopharmacology.  14:459-477. 2011
2011 Roles of a novel molecule 'shati' in the development of methamphetamine-induced dependenceCurrent Neuropharmacology.  9:104-108. 2011
2010 Enhanced dopamine function in DISC1-L100P mutant mice: Implications for schizophreniaGenes, Brain and Behavior.  9:777-789. 2010
2010 Oral supplementation with Leu-Ile, a hydrophobic dipeptide, prevents the impairment of memory induced by amyloid beta in mice via restraining the hyperphosphorylation of extracellular signal-regulated kinaseBehavioural Brain Research.  210:184-190. 2010
2010 Usp46, encoding a ubiquitin specific peptidase, is a quantitative trait gene underlying "behavioral despair" in mice 2010
2010 Silibinin attenuates cognitive deficits and decreases of dopamine and serotonin induced by repeated methamphetamine treatmentBehavioural Brain Research.  207:387-393. 2010
2010 Knockdown of DISC1 by In Utero Gene Transfer Disturbs Postnatal Dopaminergic Maturation in the Frontal Cortex and Leads to Adult Behavioral DeficitsNeuron.  65:480-489. 2010
2010 Combined effect of neonatal immune activation and mutant DISC1 on phenotypic changes in adulthoodBehavioural Brain Research.  206:32-37. 2010
2009 Silibinin attenuates amyloid β25-35 peptide-induced memory impairments: Implication of inducible nitric-oxide synthase and tumor necrosis factor-α in miceJournal of Pharmacology and Experimental Therapeutics.  331:319-326. 2009
2009 Usp46 is a quantitative trait gene regulating mouse immobile behavior in the tail suspension and forced swimming testsNature Genetics.  41:688-695. 2009
2009 The long-lasting effects of cross-fostering on the emotional behavior in ICR miceBehavioural Brain Research.  198:172-178. 2009
2008 A novel molecule 'shati' increases dopamine uptake via the induction of tumor necrosis factor-α in pheochromocytoma-12 cellsJournal of Neurochemistry.  107:1697-1708. 2008
2008 Identification of Piccolo as a regulator of behavioral plasticity and dopamine transporter internalizationMolecular Psychiatry.  13:451-463. 2008
2008 Piccolo regulates dopamine transporter internalization via PIP2Molecular Psychiatry.  13:349. 2008
2008 Genes and molecules that can potentiate or attenuate psychostimulant dependence: Relevance of data from animal models to human addictionAnnals of the New York Academy of Sciences.  1141:76-95. 2008
2007 Tumor Necrosis Factor-α and Its Inducer Inhibit Morphine-Induced Rewarding Effects and SensitizationBiological Psychiatry.  62:658-668. 2007
2007 Role of matrix metalloproteinase and tissue inhibitor of MMP in methamphetamine-induced behavioral sensitization and reward: Implications for dopamine receptor down-regulation and dopamine releaseJournal of Neurochemistry.  102:1548-1560. 2007
2007 A novel molecule "shati" is involved in methamphetamine-induced hyperlocomotion, sensitization, and conditioned place preference 2007
2007 Enduring vulnerability to reinstatement of methamphetamine-seeking behavior in glial cell line-derived neurotrophic factor mutant miceThe FASEB Journal.  21:1994-2004. 2007
2007 Involvement of glial cell line-derived neurotrophic factor in inhibitory effects of a hydrophobic dipeptide Leu-Ile on morphine-induced sensitization and rewarding effectsBehavioural Brain Research.  179:167-171. 2007
2007 An Inducer for Glial Cell Line-Derived Neurotrophic Factor and Tumor Necrosis Factor-α Protects Against Methamphetamine-Induced Rewarding Effects and SensitizationBiological Psychiatry.  61:890-901. 2007
2007 Reduction of methamphetamine-induced sensitization and reward in matrix metalloproteinase-2 and -9-deficient miceJournal of Neurochemistry.  100:1579-1588. 2007
2007 The roles of glial cell line-derived neurotrophic factor, tumor necrosis factor-α, and an inducer of these factors in drug dependenceJournal of Pharmacological Sciences.  104:116-121. 2007

Education And Training

  • Doctor of Philosophy in Neuropharmacology, Nagoya University 2007
  • Master of Science in Pharmaceutical Sciences, Chiba University 2003
  • Bachelor of Science or Mathematics in Pharmacy, Tokyo University of Pharmacy and Life Sciences 2001
  • Full Name

  • Minae Niwa