Positions

Overview

  • Dr. Mrug is a Professor of Medicine in the Division of Nephrology at the University of Alabama at Birmingham (UAB) where he trains the next generation of physicians and scientists. Dr. Mrug is recognized as one of “Top Doctors” by Castle Connolly Medical Ltd. He co-founded and co-directs the UAB Polycystic Kidney Disease (PKD) Clinic and oversees clinical PKD research activities at UAB (since 2009). This includes the CRISP study, an NIH-funded collaborative effort between Emory University, University of Kansas, Mayo Clinic, UAB and University of Pittsburgh that has led to many seminal discoveries. He also coordinated the REPRISE clinical trial for UAB; outcomes of this study played a crucial role in the recent FDA approval of tolvaptan as the first treatment for autosomal dominant PKD (ADPKD). Dr. Mrug’s clinical research interests are centered on the development of statistical models for prediction of the decline in the kidney function in patients with ADPKD over time and better identification of those patients that may benefit most from therapeutic interventions. Dr. Mrug’s basic research (funded since 2005) is focused on the identification of molecular pathways that modulate progression of renal cystic diseases, especially those related to inflammation. He also directs the Therapeutics Development and Screening Core, one of four cores within the UAB Hepatorenal Fibrocystic Disease Core Center (HRFD CC). The UAB HRFD CC is one of four NIH-funded P30 centers focused on PKD, with the other three PKD Core Centers being located at University of Kansas, Mayo Clinic and University of Maryland. The mission of these centers is the development of innovative technologies to advance PKD research and providing access to these resources to other scientists to help them promote PKD research in institutions where such resources are not available. The activities of the UAB HRFD CC are centered on Autosomal Recessive PKD (ARPKD) and other recessive fibrocystic disorders affecting the kidney and liver. Dr. Mrug also serves as the Scientific Advisory Committee Chair for the PKD Foundation’s Board of Trustees.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2019 Growth Pattern of Kidney Cyst Number and Volume in Autosomal Dominant Polycystic Kidney DiseaseClinical Journal of the American Society of Nephrology.  14:823-833. 2019
    2019 Long-term trajectory of kidney function in autosomal-dominant polycystic kidney diseaseKidney International.  95:1253-1261. 2019
    2019 Single-cell RNA sequencing identifies candidate renal resident macrophage gene expression signatures across speciesJournal of the American Society of Nephrology.  30:767-781. 2019
    2019 Heterozygous Pkhd1 C642* mice develop cystic liver disease and proximal tubule ectasia that mimics radiographic signs of medullary sponge kidneyAJP - Renal Physiology.  316:F463-F472. 2019
    2019 Truncating PKHD1 and PKD2 mutations alter energy metabolismAJP - Renal Physiology.  316:F414-F425. 2019
    2019 Resident macrophages reprogram toward a developmental state after acute kidney injury.JCI insight.  4. 2019
    2019 Mks6 mutations reveal tissue-and cell type-specific roles for the cilia transition zoneFederation proceedings.  33:1440-1455. 2019
    2019 Urinary T cells correlate with rate of renal function loss in autosomal dominant polycystic kidney diseasePhysiological Reports.  7. 2019
    2018 Relationship between caffeine intake and autosomal dominant polycystic kidney disease progression: A retrospective analysis using the CRISP cohortBMC Nephrology.  19. 2018
    2018 A practical guide for treatment of rapidly progressive ADPKD with tolvaptanJournal of the American Society of Nephrology.  29:2458-2470. 2018
    2018 Casein kinase 1ε and 1α as novel players in polycystic kidney disease and mechanistic targets for (R)-roscovitine and (S)-CR8AJP - Renal Physiology.  315:F57-F73. 2018
    2018 Baseline total kidney volume and the rate of kidney growth are associated with chronic kidney disease progression in Autosomal Dominant Polycystic Kidney DiseaseKidney International.  93:691-699. 2018
    2017 Image texture features predict renal function decline in patients with autosomal dominant polycystic kidney diseaseKidney International.  92:1206-1216. 2017
    2017 Performance of the CKD-EPI Equation to Estimate GFR in a Longitudinal Study of Autosomal Dominant Polycystic Kidney DiseaseAmerican Journal of Kidney Diseases.  69:482-484. 2017
    2017 Recovery of methotrexate-induced anuric acute kidney injury after glucarpidase therapy.SAGE Open Medical Case Reports.  5:2050313X17705050. 2017
    2017 Uric Acid Excretion Predicts Increased Blood Pressure Among American Adolescents of African DescentAmerican Journal of the Medical Sciences.  353:336-341. 2017
    2016 International Multi-Specialty Delphi Survey: Identification of Diagnostic Criteria for Hepatic and Renal Cyst InfectionNephron.  134:205-214. 2016
    2016 Automated segmentation of liver and liver cysts from bounded abdominal MR images in patients with autosomal dominant polycystic kidney diseasePhysics in Medicine and Biology.  61:7864-7880. 2016
    2016 Uric acid excretion predicts increased aggression in urban adolescentsPhysiology and Behavior.  163:144-148. 2016
    2016 Automated segmentation of kidneys from mr images in patients with autosomal dominant polycystic kidney diseaseClinical Journal of the American Society of Nephrology.  11:576-584. 2016
    2016 Predicted mutation strength of nontruncating PKD1 mutations AIDS genotype-phenotype correlations in autosomal dominant polycystic kidney diseaseJournal of the American Society of Nephrology.  27:2872-2884. 2016
    2015 Genetic and informatic analyses implicate Kif12 as a candidate gene within the Mpkd2 locus that modulates renal cystic disease severity in the Cys1cpk mousePLoS ONE.  10. 2015
    2015 A comparison of ultrasound and magnetic resonance imaging shows that kidney length predicts chronic kidney disease in autosomal dominant polycystic kidney diseaseKidney International.  88:146-151. 2015
    2015 Autosomal-dominant polycystic kidney disease (ADPKD): Executive summary from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies ConferenceKidney International.  88:17-27. 2015
    2015 Imaging classification of autosomal dominant polycystic kidney disease: A simple model for selecting patients for clinical trialsJournal of the American Society of Nephrology.  26:160-172. 2015
    2014 Complement C3 activation in cyst fluid and urine from autosomal dominant polycystic kidney disease patientsJournal of Internal Medicine.  276:539-540. 2014
    2014 Novel methodology to evaluate renal cysts in polycystic kidney diseaseAmerican Journal of Nephrology.  39:210-217. 2014
    2013 Innovations in studying in vivo cell behavior and pharmacology in complex tissues - Microvascular endothelial cells in the spotlightCell and Tissue Research.  354:647-669. 2013
    2013 Beware the low HDAC11: Males at risk for ischemic kidney injuryAJP - Renal Physiology.  305. 2013
    2013 Novel approach to estimate kidney and cyst volumes using mid-slice magnetic resonance images in polycystic kidney diseaseAmerican Journal of Nephrology.  38:333-341. 2013
    2013 Segmentation of individual renal cysts from mr images in patients with autosomal dominant polycystic kidney diseaseClinical Journal of the American Society of Nephrology.  8:1089-1097. 2013
    2013 Proximal tubule proliferation is insufficient to induce rapid cyst formation after cilia disruptionJournal of the American Society of Nephrology.  24:456-464. 2013
    2013 Urinary Proteomic Biomarkers for Diagnosis and Risk Stratification of Autosomal Dominant Polycystic Kidney Disease: A Multicentric StudyPLoS ONE.  8. 2013
    2013 Renal macrophages in autosomal recessive polycystic kidney diseaseNephrology.  18:746. 2013
    2012 Impact of ultrasound-guided kidney biopsy simulation on trainee confidence and biopsy outcomesAmerican Journal of Nephrology.  36:570-574. 2012
    2012 Microarray analysis of normal and abnormal chick ventricular myocardial developmentPhysiological Research.  61. 2012
    2012 Kidney injury accelerates cystogenesis via pathways modulated by heme oxygenase and complementJournal of the American Society of Nephrology.  23:1161-1171. 2012
    2011 Potentially modifiable factors affecting the progression of autosomal dominant polycystic kidney diseaseClinical Journal of the American Society of Nephrology.  6:640-647. 2011
    2010 Comprehensive human urine standards for comparability and standardization in clinical proteome analysisPROTEOMICS - Clinical Applications.  4:464-478. 2010
    2010 Renal CD14 expression correlates with the progression of cystic kidney diseaseKidney International.  78:550-560. 2010
    2010 Simulation of real-time ultrasound-guided renal biopsyKidney International.  78:705-707. 2010
    2009 Validation of endogenous internal real-time PCR controls in renal tissuesAmerican Journal of Nephrology.  30:413-417. 2009
    2009 C3 polymorphisms and outcomes of renal allograftsNew England Journal of Medicine.  360:2477-2479. 2009
    2008 Overexpression of innate immune response genes in a model of recessive polycystic kidney diseaseKidney International.  73:63-76. 2008
    2008 Response to 'Overexpression of complement-component genes in Han:SPRD rats a model of polycystic kidney disease'Kidney International.  73:1325. 2008
    2006 Blood-borne stem cells differentiate into vascular and cardiac lineages during normal developmentJournal of Hematotherapy.  15:17-28. 2006
    2005 Kinesin family member 12 is a candidate polycystic kidney disease modifier in the cpk mouseJournal of the American Society of Nephrology.  16:905-916. 2005
    2004 Angiotensin II Receptor Type 1 Expression in Erythroid Progenitors: Implications for the Pathogenesis of Postrenal Transplant ErythrocytosisSeminars in Nephrology.  24:120-130. 2004
    2002 Hemothorax and retroperitoneal hematoma after anticoagulation with enoxaparinSouthern Medical Journal.  95:936-938. 2002
    2002 Refinement of the autosomal recessive polycystic kidney disease (PKHD1) interval and exclusion of an EF hand-containing gene as a PKHD1 candidate geneAmerican Journal of Medical Genetics.  110:346-352. 2002
    2002 Cystin, a novel cilia-associated protein, is disrupted in the cpk mouse model of polycystic kidney disease.Journal of Clinical Investigation.  109:533-540. 2002
    2002 Cystin, a novel cilia-associated protein, is disrupted in the cpk mouse model of polycystic kidney diseaseJournal of Clinical Investigation.  109:533-540. 2002
    2002 Not one but two inflammatory bowel disease susceptibility loci map to chromosome 16American Journal of Gastroenterology.  97:2464-2465. 2002
    2002 PKHD1, the polycystic kidney and hepatic disease 1 gene, encodes a novel large protein containing multiple immunoglobulin-like plexin-transcription-factor domains and parallel beta-helix 1 repeatsAmerican Journal of Human Genetics.  70:1305-1317. 2002
    2001 An integrated genetic and physical map of the 650-kb region containing the congenital polycystic kidney (cpk) locus on mouse chromosome 12Cytogenetics and Cell Genetics.  94:55-61. 2001
    2001 Non-anemic homozygous β thalassemia in an african-american family: Association of high fetal hemoglobin levels with β thalassemia allelesAmerican Journal of Hematology.  68:43-50. 2001
    2000 Mapping of mouse α1(XIII) collagen to chromosome 10 and its exclusion as a kd candidate geneBiochemical Genetics.  38:337-340. 2000
    2000 Genomic structure of the gene for the human p1 protein (MCM3) and its exclusion as a candidate for autosomal recessive polycystic kidney diseaseEuropean Journal of Human Genetics.  8:163-166. 2000
    1999 Genomic organization of the KIAA0057 gene that encodes a TRAM-like protein and its exclusion as a polycystic kidney and hepatic disease 1 (PKHD1) candidate geneMammalian Genome.  10:1175-1178. 1999
    1997 Angiotensin II stimulates proliferation of normal early erythroid progenitorsJournal of Clinical Investigation.  100:2310-2314. 1997
    1997 'Complicated' autosomal dominant familial spastic paraplegia is genetically distinct from 'pure' formsArchives of Neurology -Chigago-.  54:379-384. 1997
    1997 The gene for autosomal dominant craniometaphyseal dysplasia maps to chromosome 5p and is distinct from the growth hormone-receptor geneAmerican Journal of Human Genetics.  61:918-923. 1997
    1996 Identification of highly polymorphic microsatellites in the rhesus macaque Macaca mulatta by cross-species amplificationMolecular Ecology.  5:157-159. 1996
    1993 Polymorphisms in the pseudoautosomal regions of X and Y in DNA diagnosisVnit¿nÍ LÉka¿stvÍ.  39:959-963. 1993

    Education And Training

  • Doctor of Medicine, 1995
  • University of South Alabama, Internship 2000
  • University of South Alabama, Residency 2002
  • UAB Hospital, Postdoctoral Fellowship 2004
  • Full Name

  • Michal Mrug