Positions

Overview

  • Dr. McDonald is an Assistant Professor of Medicine in the UAB Division of Pulmonary, Allergy, and Critical Care Medicine. She completed her PhD training in genetic epidemiology with Dr. Suzanne Leal at Baylor College of Medicine. Following her graduate training, Dr. McDonald completed postdoctoral training with Dr. Ed Silverman in Channing Division of Network Medicine, Harvard School of Medicine/Brigham and Women's Medicine.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2018 Longitudinal Phenotypes and Mortality in Preserved Ratio Impaired Spirometry in the COPDGene Study.American Journal of Respiratory and Critical Care Medicine.  198:1397-1405. 2018
    2018 Whole-Genome Sequencing in Severe Chronic Obstructive Pulmonary Disease.American Journal of Respiratory Cell and Molecular Biology.  59:614-622. 2018
    2018 Genetic variants predicting aerobic capacity response to training are also associated with skeletal muscle oxidative capacity in moderate-to-severe COPD.Physiological Genomics.  50:688-690. 2018
    2018 Blood eosinophil count thresholds and exacerbations in patients with chronic obstructive pulmonary diseaseJournal of Allergy and Clinical Immunology.  141:2037-2047.e10. 2018
    2018 Common and Rare Variants Genetic Association Analysis of Cigarettes per Day Among Ever-Smokers in Chronic Obstructive Pulmonary Disease Cases and ControlsNicotine and Tobacco Research2018
    2018 Pectoralis muscle area and mortality in smokers without airflow obstruction.Respiratory Research.  19:62. 2018
    2018 Lung, Fat and Bone: Increased Adiponectin Associates with the Combination of Smoking-Related Lung Disease and Osteoporosis.Chronic obstructive pulmonary diseases (Miami, Fla.).  5:134-143. 2018
    2018 Asthma Is a Risk Factor for Respiratory Exacerbations Without Increased Rate of Lung Function Decline: Five-Year Follow-up in Adult Smokers From the COPDGene Study.Chest.  153:368-377. 2018
    2018 Lobar Emphysema Distribution Is Associated With 5-Year Radiological Disease ProgressionChest.  153:65-76. 2018
    2017 Chest computed tomography-derived low fat-free mass index and mortality in COPD.European Respiratory Journal.  50. 2017
    2017 Handgrip Strength in Chronic Obstructive Pulmonary Disease. Associations with Acute Exacerbations and Body Composition.Annals of the American Thoracic Society.  14:1638-1645. 2017
    2017 Multiomics Approach to Asthma: Navigating the Network.American Journal of Respiratory Cell and Molecular Biology.  57:381-382. 2017
    2017 Body mass index change in gastrointestinal cancer and chronic obstructive pulmonary disease is associated with Dedicator of Cytokinesis 1.Journal of Cachexia, Sarcopenia and Muscle.  8:428-436. 2017
    2017 Sex-Based Genetic Association Study Identifies CELSR1 as a Possible Chronic Obstructive Pulmonary Disease Risk Locus among Women.American Journal of Respiratory Cell and Molecular Biology.  56:332-341. 2017
    2017 Obesity Is Associated With Increased Morbidity in Moderate to Severe COPD.Chest.  151:68-77. 2017
    2017 Susceptibility to Childhood Pneumonia: A Genome-Wide Analysis.American Journal of Respiratory Cell and Molecular Biology.  56:20-28. 2017
    2016 Clinical, physiologic, and radiographic factors contributing to development of hypoxemia in moderate to severe COPD: a cohort study.BMC Pulmonary Medicine.  16:169. 2016
    2016 A genome-wide analysis of the response to inhaled β2-agonists in chronic obstructive pulmonary disease.Pharmacogenomics Journal.  16:326-335. 2016
    2016 Common Genetic Polymorphisms Influence Blood Biomarker Measurements in COPD.PLoS Genetics.  12:e1006011. 2016
    2016 Sarcopenic Obesity, Functional Outcomes, and Systemic Inflammation in Patients With Chronic Obstructive Pulmonary Disease.Journal of the American Medical Directors Association.  17:712-718. 2016
    2015 A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry.BMC Genetics.  16:138. 2015
    2015 Continuous fat-free mass decline in COPD: fact or fiction?European Respiratory Journal.  46:1496-1498. 2015
    2015 Reduced Bone Density and Vertebral Fractures in Smokers. Men and COPD Patients at Increased Risk.Annals of the American Thoracic Society.  12:648-656. 2015
    2015 IREB2 and GALC are associated with pulmonary artery enlargement in chronic obstructive pulmonary disease.American Journal of Respiratory Cell and Molecular Biology.  52:365-376. 2015
    2014 Common genetic variants associated with resting oxygenation in chronic obstructive pulmonary disease.American Journal of Respiratory Cell and Molecular Biology.  51:678-687. 2014
    2014 Non-emphysematous chronic obstructive pulmonary disease is associated with diabetes mellitus.BMC Pulmonary Medicine.  14:164. 2014
    2014 Chest CT measures of muscle and adipose tissue in COPD: gender-based differences in content and in relationships with blood biomarkers.Academic Radiology.  21:1255-1261. 2014
    2014 Phenotypic and genetic heterogeneity among subjects with mild airflow obstruction in COPDGene.Respiratory Medicine.  108:1469-1480. 2014
    2014 Genetic susceptibility for chronic bronchitis in chronic obstructive pulmonary disease.Respiratory Research.  15:113. 2014
    2014 DNAH5 is associated with total lung capacity in chronic obstructive pulmonary disease.Respiratory Research.  15:97. 2014
    2014 Genome-wide association identifies regulatory Loci associated with distinct local histogram emphysema patterns.American Journal of Respiratory and Critical Care Medicine.  190:399-409. 2014
    2014 Epidemiology, genetics, and subtyping of preserved ratio impaired spirometry (PRISm) in COPDGene.Respiratory Research.  15:89. 2014
    2014 The clinical and genetic features of COPD-asthma overlap syndrome.European Respiratory Journal.  44:341-350. 2014
    2014 A comparative analysis of family-based and population-based association tests using whole genome sequence dataBMC Proceedings.  8. 2014
    2014 Quantitative computed tomography measures of pectoralis muscle area and disease severity in chronic obstructive pulmonary disease. A cross-sectional study.Annals of the American Thoracic Society.  11:326-334. 2014
    2014 Risk loci for chronic obstructive pulmonary disease: a genome-wide association study and meta-analysis.Lancet Respiratory Medicine.  2:214-225. 2014
    2014 Beyond GWAS in COPD: probing the landscape between gene-set associations, genome-wide associations and protein-protein interaction networks.Human Heredity.  78:131-139. 2014
    2012 Genetic association of cyclic AMP signaling genes with bipolar disorder.Translational Psychiatry.  2:e169. 2012
    2012 The chicken frizzle feather is due to an α-keratin (KRT75) mutation that causes a defective rachis.PLoS Genetics.  8:e1002748. 2012
    2011 Genome-wide association study identifies a susceptibility locus for thoracic aortic aneurysms and aortic dissections spanning FBN1 at 15q21.1.Nature Genetics.  43:996-1000. 2011
    2011 Recurrent chromosome 16p13.1 duplications are a risk factor for aortic dissections.PLoS Genetics.  7:e1002118. 2011
    2009 Novel autosomal recessive non-syndromic hearing impairment locus (DFNB71) maps to chromosome 8p22-21.3.Journal of Human Genetics.  54:141-144. 2009
    2008 Mapping of a new autosomal recessive non-syndromic hearing impairment locus (DFNB45) to chromosome 1q43-q44.Clinical Genetics.  73:395-398. 2008
    2008 Splice-site mutations in the TRIC gene underlie autosomal recessive nonsyndromic hearing impairment in Pakistani families.Journal of Human Genetics.  53:101-105. 2008
    2005 Reduced endothelial secretion and plasma levels of transforming growth factor-β1 in patients with hereditary hemorrhagic telangiectasia type 1Cardiovascular Research.  68:155-164. 2005
    2001 Potential Role of Modifier Genes Influencing Transforming Growth Factor-β1 Levels in the Development of Vascular Defects in Endoglin Heterozygous Mice with Hereditary Hemorrhagic TelangiectasiaAmerican Journal of Pathology.  158:2011-2020. 2001

    Research Overview

  • Dr. McDonald’s research is focused on Network Medicine Approaches to Cachexia in COPD. Her research program is currently funded by the National Institutes of Health (K99/R00) and the Parker B. Francis Foundation. Dr. McDonald is an active member of the American Thoracic Society, the American Society of Human Genetics and the Society on Sarcopenia, Cachexia and Wasting Disorders.
  • Education And Training

  • Bachelor of Science or Mathematics in Biochemistry, University of Waterloo
  • Doctor of Philosophy in Molecular Biophysics, Baylor College of Medicine
  • Master of Science in Epidemiology, University of Saskatchewan
  • Full Name

  • Merry-Lynn Donnelly
  • Blazerid

  • mlmcdon