• I am a translational physician scientist with a clinical practice in a tertiary 24-bed Pediatric Intensive Care Unit (PICU). My basic science research is focused on understanding the role and impact of protease dysregulation in the pathogenesis of Respiratory Syncytial Virus (RSV) lung disease and acute lung injury in children. In 2012, I was selected to be a Pediatric Critical Care Scientist Development Program Scholar (sponsored by NICHD), and in 2014, I successfully secured my own funding from NHLBI. I am currently the PI of a RCT of macrolide treatment in severe pediatric RSV infection. I am also the lead site PI for several multi-centered trials including the NIH funded 1. PROSpect trial that seeks to determine the effects of prone positioning and high frequency ventilation on pediatric acute respiratory distress syndrome (PARDS) outcome; and 2. ADAPT trial what investigates the current approaches for pediatric traumatic injury. In addition, I am the lead physician in the development of the Sensory Pathway (with the focus of removing barriers to diagnosis and improving delivery of care, particularly for special needs children with sensory sensitivities) and provide oversight to the implementation of the pathway at Children's of Alabama.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2018 Viral Sepsis in Children.Frontiers in Pediatrics.  6:252. 2018
    2017 A call to the senses: The community approachFrontiers in Pediatrics.  5. 2017
    2017 Goodbyes Are Not Forever.JAMA Pediatrics.  171:109. 2017
    2017 A Community-Based Sensory Training Program Leads to Improved Experience at a Local Zoo for Children with Sensory Challenges.Frontiers in Pediatrics.  5:193. 2017
    2016 Love at First SightJAMA Pediatrics.  170:1120-1120. 2016
    2016 Toll-Like Receptor 4 Engagement Mediates Prolyl Endopeptidase Release from Airway Epithelia via Exosomes.American Journal of Respiratory Cell and Molecular Biology.  54:359-369. 2016
    2016 Viral Infection in the Development and Progression of Pediatric Acute Respiratory Distress Syndrome.Frontiers in Pediatrics.  4:128. 2016
    2015 Chromobacterium Violaceum Sepsis: Rethinking Conventional Therapy to Improve Outcome.The American Journal of Case Reports.  16:740-744. 2015
    2015 Balance is in the MomentFrontiers in Pediatrics.  3. 2015
    2015 Addendum: Kong, M.Y.; Whitley, R.J.; Peng, N.; Oster, R.; Schoeb, T.R.; Sullender, W.; Ambalavanan, N.; Clancy, J.P.; Gaggar, A.; Blalock J.E. Matrix Metalloproteinase-9 Mediates RSV Infection in Vitro and in Vivo. Viruses 2015, 30, 7, 4230–4253.Viruses.  7:5609. 2015
    2015 Matrix Metalloproteinase-9 Mediates RSV Infection in Vitro and in Vivo.Viruses.  7:4230-4253. 2015
    2015 Diagnosis and History Taking in Children with Autism Spectrum Disorder: Dealing with the ChallengesFrontiers in Pediatrics.  3. 2015
    2014 Pulmonary matrix metalloproteinase-9 activity in mechanically ventilated children with respiratory syncytial virus.European Respiratory Journal.  43:1086-1096. 2014
    2013 Respiratory syncytial virus infection disrupts monolayer integrity and function in cystic fibrosis airway cells.Viruses.  5:2260-2271. 2013
    2011 Early elevation of matrix metalloproteinase-8 and -9 in pediatric ARDS is associated with an increased risk of prolonged mechanical ventilation.PLoS ONE.  6:e22596. 2011
    2007 Is hyperglycemia really harmful? A critical appraisal of "Persistent hyperglycemia in critically ill children" by Faustino and Apkon (J Pediatr 2005; 146:30-34).Pediatric Critical Care Medicine.  8:482-485. 2007
    2007 Matrix metalloprotease-9 dysregulation in lower airway secretions of cystic fibrosis patients.AJP - Lung Cellular and Molecular Physiology.  293:L96-L104. 2007

    Research Overview

  • - Delineating the role and impact of protease dysregulation in the pathogenesis of Acute Lung Injury and Respiratory Syncytial Virus-induced respiratory failure in children - Critical assessment of the acutely ill non-verbal child, and development of sensory pathway to remove barriers to diagnosis in special needs children with sensory sensitivities
  • Principal Investigator On

  • Impact of RBC-derived DAMPs on Innate Immunity in Pediatric Sepsis (RBC-DAMPs)  awarded by Washington University 2018 - 2022
  • Genetic Epidemiology and Immune Response to Life- Threatening Influenza Infection in Children and Yound Adults (PICFlu)  awarded by CHILDREN'S HOSPITAL (BOSTON) 2016 - 2020
  • Massive Transfusion Epidemiology and Outcomes in Children (MATIC) Study  awarded by Washington University 2017 - 2019
  • Age of Blood in Children in Pediatric Intensive Care Units (ABC-PICU)  awarded by Washington University in St. Louis 2017 - 2019
  • Genetic and Environmental Influences on Recovery of Severe Pediatric Brain Injury. (ADAPT Genomics)  awarded by CHILDREN'S HOSPITAL MEDICAL CENTER (CINCINNATI) 2018 - 2019
  • Genetic and Environmental Influences on Recovery of Severe Pediatric Brain Injury. (ADAPT Genomics) - CR for Coordinator Effort  awarded by CHILDREN'S HOSPITAL MEDICAL CENTER (CINCINNATI) 2018 - 2019
  • Transfusion Associated Pathophysiology in MODS (TRAP-MODS)  awarded by University of California, Los Angeles 2017 - 2019
  • Matrix Metalloproteinase Driven Lung Inflammation in RSV Disease  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2014 - 2019
  • Identification of Prognostic Protein and Bioactive Lipid Biomarkers in Critically Ill Children with Influenza Infection  awarded by CHILDREN'S HOSPITAL (BOSTON) 2018 - 2019
  • Sepsis-Induced Red Cell Dysfunction (SIRD}  awarded by Washington University 2018 - 2019
  • Private Grant  awarded by Gilead Sciences 2017 - 2018
  • Multiple Therapies for Pediatric TBI: Comparative Effectiveness Approach (ADAPT)  awarded by CHILDREN'S NATIONAL MEDICAL CENTER - NEW 2017 - 2018
  • Genetic Epidemiology of Life-Threatening Influenza in Children  awarded by CHILDREN'S HOSPITAL (BOSTON) 2015 - 2016
  • RSV-Mediated Regulation of Neutrophilic Inflammation in CF Lung Disease  awarded by KAUL PEDIATRIC RESEARCH INSTITUTE 2013 - 2015
  • Pediatric Critical Care Scientist Development Program: "RSV-Induced Respiratory Failure: Role of MMP-9 in Lung Injury Through Generation of PGP"  awarded by University of Utah 2012 - 2013
  • Private Grant  awarded by MedImmune 2007 - 2012
  • Matrix Metalloproteinase-9 in Pediatric RSV-Induced Respiratory Failure  awarded by CHILDREN’S CENTER FOR RESEARCH AND INNOVATION 2008 - 2011
  • Full Name

  • Michele Kong
  • Blazerid

  • mkong