Positions

Selected Publications

Academic Article

Year Title Altmetric
2019 Basal and Evoked Neurotransmitter Levels in Parkin, DJ-1, PINK1 and LRRK2 Knockout Rat StriatumNeuroscience.  409:169-179. 2019
2019 Analysis of α-synuclein pathology in PINK1 knockout rat brainsFrontiers in Neuroscience.  13. 2019
2018 Reactive species balance via GTP cyclohydrolase i regulates glioblastoma growth and tumor initiating cell maintenanceNeuro-Oncology.  20:1055-1067. 2018
2018 New Developments in Genetic rat models of Parkinson's DiseaseMovement Disorders.  33:717-729. 2018
2017 Parkin and PINK1 functions in oxidative stress and neurodegenerationBrain Research Bulletin.  133:51-59. 2017
2017 Fbxl18 targets LRRK2 for proteasomal degradation and attenuates cell toxicityNeurobiology of Disease.  98:122-136. 2017
2015 The role of ventral striatal cAMP signaling in stress-induced behaviorsNature Neuroscience.  18:1094-1100. 2015
2014 Phenotypic characterization of recessive gene knockout rat models of Parkinson's diseaseNeurobiology of Disease.  70:190-203. 2014
2014 Surprising behavioral and neurochemical enhancements in mice with combined mutations linked to Parkinson's diseaseNeurobiology of Disease.  62:113-123. 2014
2013 Parkin-Dependent Degradation of the F-Box Protein Fbw7β Promotes Neuronal Survival in Response to Oxidative Stress by Stabilizing Mcl-1Molecular and Cellular Biology.  33:3627-3643. 2013
2013 Analysis of inflammation-related nigral degeneration and locomotor function in DJ-1 -/- miceJournal of Neuroinflammation.  10. 2013
2013 Behavioral and neurotransmitter abnormalities in mice deficient for Parkin, DJ-1 and superoxide dismutasePLoS ONE.  8. 2013
2012 A mutation in CLOCK leads to altered dopamine receptor functionJournal of Neurochemistry.  123:124-134. 2012
2012 Number and Brightness Analysis of LRRK2 Oligomerization in Live CellsBiophysical Journal.  102:L41-L43. 2012
2012 Transcriptional Activation of Low-Density Lipoprotein Receptor Gene by DJ-1 and Effect of DJ-1 on Cholesterol HomeostasisPLoS ONE.  7:e38144-e38144. 2012
2011 Lipopolysaccharide and tumor necrosis factor regulate parkin expression via Nuclear factor-kappa BPLoS ONE.  6. 2011
2011 Specific role of VTA dopamine neuronal firing rates and morphology in the reversal of anxiety-related, but not depression-related behavior in the clockδ19 mouse model of maniaNeuropsychopharmacology.  36:1478-1488. 2011
2011 Alternative mitochondrial electron transfer as a novel strategy for neuroprotectionJournal of Biological Chemistry.  286:16504-16515. 2011
2010 Attention-deficit/hyperactivity phenotype in mice lacking the cyclin-dependent kinase 5 cofactor p35Biological Psychiatry.  68:1163-1171. 2010
2010 Neuroinflammation in Parkinson's disease: Its role in neuronal death and implications for therapeutic interventionNeurobiology of Disease.  37:510-518. 2010
2010 Loss of function of DJ-1 triggered by Parkinson's disease-associated mutation is due to proteolytic resistance to caspase-6Cell Death and Differentiation.  17:158-169. 2010
2009 Transcriptional repression of p53 by parkin and impairment by mutations associated with autosomal recessive juvenile Parkinson's diseaseNature Cell Biology.  11:1370-1375. 2009
2009 Parkin-mediated ubiquitination regulates phospholipase C-γ1Journal of Cellular and Molecular Medicine.  13:3061-3068. 2009
2009 Regulation of LRRK2 stability by the E3 ubiquitin ligase CHIPPLoS ONE.  4. 2009
2009 Increased DJ-1 expression under oxidative stress and in Alzheimer's disease brainsMolecular Neurodegeneration.  4:12-12. 2009
2008 Parkin deficiency increases vulnerability to inflammation-related nigral degenerationJournal of Neuroscience.  28:10825-10834. 2008
2006 Parkin Protects against Mitochondrial Toxins and β-Amyloid Accumulation in Skeletal Muscle CellsJournal of Biological Chemistry.  281:12809-12816. 2006
2005 Nigrostriatal Dopaminergic Deficits and Hypokinesia Caused by Inactivation of the Familial Parkinsonism-Linked Gene DJ-1Neuron.  45:489-496. 2005
2004 Mitochondrial Dysfunction and Oxidative Damage in parkin -deficient MiceJournal of Biological Chemistry.  279:18614-18622. 2004
2003 Parkin-deficient Mice Exhibit Nigrostriatal Deficits but Not Loss of Dopaminergic NeuronsJournal of Biological Chemistry.  278:43628-43635. 2003
2002 alpha-Synuclein is phosphorylated in synucleinopathy lesions.Nature Cell Biology.  4:160-164. 2002
2001 -Synuclein occurs in lipid-rich high molecular weight complexes, binds fatty acids, and shows homology to the fatty acid-binding proteinsProceedings of the National Academy of Sciences.  98:9110-9115. 2001
2000 Is there a cause-and-effect relationship between alpha-synuclein fibrillization and Parkinson's disease?Nature Cell Biology.  2:E115-E119. 2000
1997 Native-like structure of a protein-folding intermediate bound to the chaperonin GroELProceedings of the National Academy of Sciences.  94:1080-1085. 1997
1992 The solution structure of eglin c based on measurements of many NOEs and coupling constants and its comparison with X-ray structuresProtein Science.  1:736-751. 1992
1992 NMR studies of structure and dynamics of isotope enriched proteinsBiopolymers.  32:381-390. 1992

Education And Training

  • Doctor of Philosophy in Biochemistry, Biophysics and Molecular Biology, Yale University 1998
  • Full Name

  • Matthew Goldberg