Positions

Overview

  • My undergraduate was completed at Ball State University in Muncie Indiana. Upon graduating I was recruited and worked as a technician in the laboratory of Dr. Roger Reeves at Johns Hopkins School of Medicine and eventually went to Eli Lilly in Indianapolis, IN before going to Grad School. My graduate work was done with Dr. Bonnie Asch at Roswell Park Cancer Institute in Buffalo, NY. After graduating I did a postdoctoral fellowship with Dr. Rosa Serra at the University of Cincinnati, Cincinnati OH.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2019 Podocyte-specific expression of cre recombinase promotes glomerular basement membrane thickeningAJP - Renal Physiology.  316:F1026-F1040. 2019
    2019 Single-cell RNA sequencing identifies candidate renal resident macrophage gene expression signatures across speciesJournal of the American Society of Nephrology.  30:767-781. 2019
    2019 Non-obstructive vas deferens and epididymis loss in cystic fibrosis ratsMechanisms of Development.  155:15-26. 2019
    2019 The Purple Sea Urchin Strongylocentrotus purpuratus Demonstrates a Compartmentalization of Gut Bacterial Microbiota, Predictive Functional Attributes, and Taxonomic Co-Occurrence.Microorganisms.  7. 2019
    2019 Resident macrophages reprogram toward a developmental state after acute kidney injury.JCI insight.  4. 2019
    2019 CYP3A5 genotype affects time to therapeutic tacrolimus level in pediatric kidney transplant recipientsPediatric Transplantation2019
    2018 Immunophenotyping and transcriptional profiling of in vitro cultured human adipose tissue derived stem cellsScientific Reports.  8. 2018
    2018 New microbe genomic variants in patients fecal community following surgical disruption of the upper human gastrointestinal tractHuman Microbiome Journal.  10:37-42. 2018
    2018 Metagenomic analysis of microbial community compositions and cold-responsive stress genes in selected antarctic lacustrine and soil ecosystemsLife.  8. 2018
    2018 STMN1 is Overexpressed in Adrenocortical Carcinoma and Promotes a More Aggressive Phenotype In VitroAnnals of Surgical Oncology.  25:792-800. 2018
    2018 β-D-N 4 -Hydroxycytidine is a potent anti-alphavirus compound that induces a high level of mutations in the viral genomeJournal of Virology.  92. 2018
    2017 Identification of donor microbe species that colonize and persist long term in the recipient after fecal transplant for recurrent Clostridium difficilenpj Biofilms and Microbiomes.  3. 2017
    2017 The Human Blood-Nerve Barrier TranscriptomeScientific Reports.  7. 2017
    2017 Well-Differentiated Thyroid Cancer Neovasculature Expresses Prostate-Specific Membrane Antigen—a Possible Novel Therapeutic TargetEndocrine Pathology.  28:339-344. 2017
    2017 Identification of new regulators of embryonic patterning and morphogenesis in Xenopus gastrulae by RNA sequencingDevelopmental Biology.  426:429-441. 2017
    2017 Metagenomics approach to the study of the gut microbiome structure and function in zebrafish Danio rerio fed with gluten formulated dietJournal of Microbiological Methods.  135:69-76. 2017
    2017 Erratum: Author Correction: Identification of donor microbe species that colonize and persist long term in the recipient after fecal transplant for recurrent Clostridium difficile.npj Biofilms and Microbiomes.  3:29. 2017
    2017 Kinase analysis of penile squamous cell carcinoma on multiple platforms to identify potential therapeutic targetsOncotarget.  8:21710-21718. 2017
    2016 Endothelial-specific inhibition of NF-κB enhances functional haematopoiesisNature Communications.  7. 2016
    2016 Reprogramming by De-bookmarking the Somatic Transcriptional Program through Targeting of BET BromodomainsCell Reports.  16:3138-3145. 2016
    2016 Allelic series of Huntington's disease knock-in mice reveals expression discorrelatesHuman Molecular Genetics.  25:1619-1636. 2016
    2016 The acetyllysine reader BRD3R promotes human nuclear reprogramming and regulates mitosisNature Communications.  7. 2016
    2016 Prostate-specific membrane antigen is a potential antiangiogenic target in adrenocortical carcinomaJournal of Clinical Endocrinology and Metabolism.  101:981-987. 2016
    2016 Uropathogenic Escherichia coli engages CD14-dependent signaling to enable bladder-macrophage-dependent control of acute urinary tract infectionJournal of Infectious Diseases.  213:659-668. 2016
    2016 Colonization potential to reconstitute a microbe community in patients detected early after fecal microbe transplant for recurrent C. difficileBMC Microbiology.  16. 2016
    2016 Burkholderia pseudomallei capsule exacerbates respiratory melioidosis but does not afford protection against antimicrobial signaling or bacterial killing in human olfactory ensheathing cellsInfection and Immunity.  84:1941-1956. 2016
    2016 Draft genome sequence of Janthinobacterium sp. Ant5-2-1, isolated from Proglacial Lake Podprudnoye in the Schirmacher Oasis of East AntarcticaGenome Announcements.  4. 2016
    2016 Somatic mutations modulate autoantibodies against galactose-deficient IgA1 in IgA nephropathyJournal of the American Society of Nephrology.  27:3278-3284. 2016
    2015 Vascular platform to define hematopoietic stem cell factors and enhance regenerative hematopoiesisStem Cell Reports.  5:881-894. 2015
    2015 Concurrent DNA Copy-Number Alterations and Mutations in Genes Related to Maintenance of Genome Stability in Uninvolved Mammary Glandular Tissue from Breast Cancer PatientsHuman Mutation.  36:1088-1099. 2015
    2015 Hypomagnesemia due to two novel TRPM6 mutationsJournal of Pediatric Endocrinology and Metabolism.  28:1373-1378. 2015
    2015 Influence of Kidney Function on Risk of Supratherapeutic International Normalized Ratio-Related Hemorrhage in Warfarin Users: A Prospective Cohort StudyAmerican Journal of Kidney Diseases.  65:701-709. 2015
    2014 Dicer expression and microRNA dysregulation associate with aggressive features in thyroid cancerSurgery.  156:1342-1350. 2014
    2014 Draft genome sequence of Hymenobacter sp. strain IS2118, isolated from a freshwater lake in Schirmacher Oasis, Antarctica, reveals diverse genes for adaptation to cold ecosystemsGenome Announcements.  2. 2014
    2014 Draft genome sequence of Pseudomonas sp. strain Ant30-3, a psychrotolerant bacterium with biodegradative attribute isolated from AntarcticaGenome Announcements.  2. 2014
    2014 Dramatic impact of using protective equipment on the level of hurling-related head injuries: An ultimately successful 27-year programmeBritish Journal of Sports Medicine.  48:147-150. 2014
    2014 Germline loss-of-function mutations in LZTR1 predispose to an inherited disorder of multiple schwannomasNature Genetics.  46:182-187. 2014
    2014 Getting started with microbiome analysis: Sample acquisition to bioinformaticsCurrent protocols in human genetics / editorial board, Jonathan L. Haines ... [et al.].  2014:18.8.1-18.8.29. 2014
    2014 Silencing of UCHL1 by CpG Promoter Hyper-methylation is Associated with Metastatic Gastroenteropancreatic Well-Differentiated Neuroendocrine (Carcinoid) TumorsAnnals of Surgical Oncology.  21:672-679. 2014
    2013 Thyroid stimulating hormone increases iodine uptake by thyroid cancer cells during BRAF silencingJournal of Surgical Research.  182:85-93. 2013
    2013 Preoperative BRAF(V600E) mutation screening is unlikely to alter initial surgical treatment of patients with indeterminate thyroid nodules: A prospective case series of 960 patientsCancer.  119:1495-1502. 2013
    2013 WNT5A Inhibits Metastasis and Alters Splicing of Cd44 in Breast Cancer CellsPLoS ONE.  8. 2013
    2013 Influence of kidney function on risk of hemorrhage among patients taking warfarin: A cohort studyAmerican Journal of Kidney Diseases.  61:354-357. 2013
    2012 Genome-wide mapping of cystitis due to Streptococcus agalactiae and Escherichia coli in mice identifies a unique bladder transcriptome that signifies pathogen-specific antimicrobial defense against urinary tract infectionInfection and Immunity.  80:3145-3160. 2012
    2012 A panel of four miRNAs accurately differentiates malignant from benign indeterminate thyroid lesions on fine needle aspirationClinical Cancer Research.  18:2032-2038. 2012
    2012 Intercellular adhesion molecule-1 (ICAM-1) is upregulated in aggressive papillary thyroid carcinomaAnnals of Surgical Oncology.  19:973-980. 2012
    2012 Innate transcriptional networks activated in bladder in response to uropathogenic Escherichia coli drive diverse biological pathways and rapid synthesis of IL-10 for defense against bacterial urinary tract infectionJournal of Immunology.  188:781-792. 2012
    2011 Transcriptome analysis of listeria monocytogenes grown on a ready-to-eat meat matrixJournal of Food Protection.  74:1104-1111. 2011
    2011 Risk stratification of indeterminate thyroid fine-needle aspiration biopsy specimens based on mutation analysisSurgery.  150:1085-1091. 2011
    2010 Warfarin dosing in patients with impaired kidney functionAmerican Journal of Kidney Diseases.  56:823-831. 2010
    2010 Group B Streptococcus (GBS) urinary tract infection involves binding of GBS to bladder uroepithelium and potent but GBS-specific induction of interleukin 1αJournal of Infectious Diseases.  201:866-870. 2010
    2009 Loss of TGF-β or Wnt5a results in an increase in Wnt/β-catenin activity and redirects mammary tumour phenotypeBreast Cancer Research.  11. 2009
    2008 VKORC1 polymorphims, haplotypes and haplotype groups on warfarin dose among African-Americans and European-AmericansPharmacogenomics.  9:1445-1458. 2008
    2008 Phenotypically Concordant and Discordant Monozygotic Twins Display Different DNA Copy-Number-Variation ProfilesAmerican Journal of Human Genetics.  82:763-771. 2008
    2006 Transforming growth factor-β signaling helps specify tumor type in DMBA and hormone-induced mammary cancersDifferentiation.  74:40-52. 2006
    2005 Mouse models of transforming growth factor β impact in breast development and cancerEndocrine-Related Cancer.  12:749-760. 2005
    2005 TGF-β, c-Cbl, and PDGFR-α the in mammary stromaDevelopmental Biology.  279:58-72. 2005
    2003 TGF-beta in mammary gland development and breast cancer.Breast Disease.  18:61-73. 2003
    2003 TGF-β mammary gland development and breast cancerBreast Disease.  18:61-73. 2003
    2002 Developmental and TGF-β-mediated regulation of Ank mRNA expression in cartilage and boneOsteoarthritis and Cartilage.  10:482-490. 2002
    2000 The mouse mammary gland requires the actin-binding protein gelsolin for proper ductal morphogenesisDevelopmental Biology.  225:407-423. 2000
    2000 Pregnancy and pregnancy outcome in hepatitis C type 1bQJM: An International Journal of Medicine.  93:597-601. 2000
    1999 Clinical outcomes after hepatitis C infection from contaminated anti-D immune globulin [1] (multiple letters)New England Journal of Medicine.  341:762-763. 1999
    1998 Molecular analysis of ras oncogenes in CIN III and in stage I and II invasive squamous cell carcinoma of the uterine cervixJournal of Clinical Pathology.  51:576-582. 1998
    1997 Re: A prospective comparison of laparoscopy and imaging in the staging of esophagogastric cancer before surgery [1] (multiple letters)American Journal of Gastroenterology.  92:1399-1400. 1997
    1997 Alterations in exon 1 of c-myc and expression of p62(c-myc) in cervical squamous cell carcinomaJournal of Clinical Pathology.  50:896-903. 1997
    1997 Genotypic mapping of HPV and assessment of EBV prevalence in endocervical lesionsJournal of Clinical Pathology.  50:904-910. 1997
    1996 Deliberate self-poisoning, unemployment, and public healthSuicide and Life-Threatening Behavior.  26:365-373. 1996
    1996 Suicide levels in Cork City 1987/1991Irish Medical Journal : Journal of the Irish Medical Association.  89:99-101. 1996
    1996 Mutations involving the endogenous ecotropic murine leukemia virus in primary mammary carcinomas of BALB/c miceCancer Letters.  99:121-127. 1996
    1996 The influence of some perinatal variables on neonatal blood pressureActa Paediatrica.  85:849-853. 1996
    1995 A Prospective Comparison of Laparoscopy and Imaging in the Staging of Esophagogastric Cancer Before SurgeryAmerican Journal of Gastroenterology.  90:2191-2194. 1995
    1995 Patient throughput in an acute geriatric unit.Irish Medical Journal : Journal of the Irish Medical Association.  88:126-128. 1995
    1994 Irish Gerontological Society - Proceedings of annual scientific and general meeting held October 1993Irish Journal of Medical Science.  163:464-474. 1994
    1994 Irish society of gastroenterology - Proceedings of the summer meeting held in cork on friday, 3rd and saturday 4th june, 1994Irish Journal of Medical Science.  163:294-304. 1994
    1994 The importance of fixation procedures on DNA template and its suitability for solution-phase polymerase chain reaction and PCR in situ hybridizationHistochemical Journal.  26:337-346. 1994
    1994 New nucleic acid amplification techniques in diagnostic pathologyJournal of the European Academy of Dermatology and Venereology.  3:78-86. 1994
    1994 PCR in situ hybridisation detection of HPV 16 in fixed CaSki and fixed SiHa cell linesJournal of Clinical Pathology.  47:933-938. 1994
    1993 Reliability of blood pressure readings in infancy.Irish Medical Journal : Journal of the Irish Medical Association.  86:171. 1993
    1993 Epidemiology of tumours of the central nervous system in Ireland.Irish Medical Journal : Journal of the Irish Medical Association.  86:87-88. 1993
    1993 Epstein-Barr virus in normal, pre-malignant, and malignant lesions of the uterine cervixJournal of Clinical Pathology.  46:931-935. 1993
    1993 Irish neurological association: Proceedings of 28th annual meeting, beaumont hospital, Dublin, 15th-16th may, 1992Irish Journal of Medical Science.  162:474-484. 1993
    1993 Oral cancer in Ireland, 1984-1988European journal of cancer. Part B, Oral oncology.  29:127-130. 1993
    1992 Epilepsy and employment, marital, education and social status.Irish Medical Journal : Journal of the Irish Medical Association.  85:17-19. 1992
    1989 Investigation of the possible effect of the chernobyl accident on irish mortality ratesIrish Journal of Medical Science.  158:114-116. 1989
    1989 Serum Bilirubin Levels with Antiepileptic DrugsEpilepsia.  30:597-602. 1989
    1987 A Comparative Study of the Relative Effects of Anticonvulsant Drugs and Dietary Folate on the Red Cell Folate Status of Patients with EpilepsyQJM: An International Journal of Medicine.  65:911-919. 1987
    1986 Factors associated with the biochemical changes in vitamin d and calcium metabolism in institutionalized patients with epilepsyIrish Journal of Medical Science.  155:181-189. 1986
    1986 A comparative study of the relative influence of different anticonvulsant drugs, UV exposure and diet on vitamin D and calcium metabolism in out-patients with epilepsyQJM: An International Journal of Medicine.  59:569-577. 1986
    1985 A prospective study between carbamazepine, phenytoin and sodium valproate as monotherapy in previously untreated and recently diagnosed patients with epilepsyJournal of Neurology, Neurosurgery and Psychiatry.  48:639-644. 1985
    1984 Irish neurological association - Meeting, Belfast, May 20th/21st, 1983Irish Journal of Medical Science.  153:152-157. 1984
    1983 Lack of effect of ingestion of vitamin E on lipoprotein-cholesterol fractions in healthy adultsIrish Medical Journal : Journal of the Irish Medical Association.  76:152-154. 1983
    1982 Screening for cystic fibrosisIrish Medical Journal : Journal of the Irish Medical Association.  75:480-481. 1982
    1982 Factors in the exfoliation sydromeBritish Journal of Ophthalmology.  66:432-437. 1982
    1979 Cerebral palsy - A regional study: Part IIIrish Medical Journal : Journal of the Irish Medical Association.  72:14-18. 1979
    1978 Cerebral palsy: A regional studyIrish Medical Journal : Journal of the Irish Medical Association.  71:568-572. 1978

    Research Overview

  • Mammary gland biology and neoplaisa - Mammary gland biology and neoplaisa - Although my research interests have been in the area of mammary gland biology and cancer I have been the Genomics Core director since 2005 and have primarily been focused on service to the research community. The Genomics Core provides DNA sequencing, SNP genotyping, DNA fingerprinting, microarray and Next-Generation sequencing services on a fee for service basis. The core is completely supported by chargebacks to investigators. In addition to the Core my research interests include how the mammary ductal tree progresses through the mammary fat pad in a structured and ordered way. We're beginning to focus on the Slit/Robo pathway, which is responsible for directional growth of axons in the brain. Specifically, we have cloned a GAP (GTPase Activating Protein) from hormonally induced mammary tumors, srGAP3, and are beginning to investigate it's role in epithelial cell migration through the mammary fat pad.

    Keywords - mammary gland, genomics, sequencing, GAPs,
  • Investigator On

  • Early Life Prevention of Breast Cancer with Combined Epigenetic Botanicals  awarded by National Cancer Institute/NIH/DHHS 2017 - 2021
  • Histone H4 Lysine16 Acetylation in Aging and Lung Fibrosis  awarded by National Institute on Aging/NIH/DHHS 2016 - 2021
  • Comprehensive Cancer Center Core Support Grant  awarded by National Cancer Institute/NIH/DHHS 2019 - 2021
  • Sensory Afferent Mechanisms Contributing to Diabetic Bladder Dysfunction  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2019 - 2020
  • Emerging Antiviral Resistance in Congenital Cytomegalovirus Infection  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2014 - 2019
  • UAB Center for AIDS Research  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2014 - 2019
  • UAB Center for AIDS Research - Genomics Core G  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2014 - 2019
  • Comprehensive Cancer Center Core Support Grant  awarded by National Cancer Institute/NIH/DHHS 2017 - 2019
  • Combinatorial Epigenetic-Based Prevention of Breast Cancer  awarded by National Cancer Institute/NIH/DHHS 2014 - 2019
  • Epigenetics of Early Life Exposure to Cancer Preventive Cruciferous Vegetables  awarded by AMERICAN INSTITUTE FOR CANCER RESEARCH 2015 - 2017
  • Comprehensive Cancer Center Core Support Grant  awarded by National Cancer Institute/NIH/DHHS 2016 - 2017
  • Epigenetics, Neurodevelopment, and Emotional Behavior  awarded by National Institute of Mental Health/NIH/DHHS 2015 - 2016
  • Maternal Epigenetic Dietary Effects on Early Breast Cancer Prevention  awarded by National Cancer Institute/NIH/DHHS 2013 - 2016
  • Completed - Comprehensive Genomics Shared Facility - Comprehensive Cancer Center Core Support Grant  awarded by National Cancer Institute/NIH/DHHS 2011 - 2016
  • Comprehensive Cancer Center Core Support Grant  awarded by National Cancer Institute/NIH/DHHS 2011 - 2016
  • Whole Exome and Comprehensive Kinomics Analysis of Penile Squamous Cell Carcinoma  awarded by Conquer Cancer Foundation of ASCO 2014 - 2015
  • Whole Exome Sequencing of Penile Squamous Cell Carcinoma to Improve Prognostication and Uncover Potentially Actionable Therapeutic Targets  awarded by FONDAZIONE IRCCS INSITUTO NAZIONLE DEI TUMORI 2014 - 2015
  • Dermal NF Biobank Award  awarded by Children's Tumor Foundation 2014
  • Upgrade of the UAB Stem Cell Institute HiSeq 2000  awarded by UNIVERSITY OF ALABAMA HEALTH SERVICES FOUNDATION 2013 - 2014
  • UAB Center for AIDS Research  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2009 - 2014
  • UAB Center for AIDS Research - DNA Sequencing  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2009 - 2014
  • Maternal Epigenetic Dietary Effects on Early Breast Cancer Prevention  awarded by National Cancer Institute/NIH/DHHS 2013
  • Completed - Comprehensive Cancer Center Core Support Grant - Micro Array SF  awarded by National Cancer Institute/NIH/DHHS 2011 - 2013
  • Education And Training

  • Doctor of Philosophy in Cell / Cellular and Molecular Biology, State University of New York System : College at Buffalo (Buffalo State College) 2000
  • Full Name

  • Michael Crowley