Positions

Overview

  • Mitchell Cohen, MD, a national leader in pediatric medicine and an internationally renowned specialist in children’s digestive disorders, is chair of the UAB Department of Pediatrics in the University of Alabama School of Medicine and physician-in-chief of Children’s of Alabama.

    Cohen is a former professor of pediatrics, vice-chair for clinical affairs, and director of the Division of Gastroenterology, Hepatology and Nutrition at Cincinnati Children’s Hospital Medical Center.

    The UAB Department of Pediatrics has more than 240 faculty members and trains more than 100 residents for careers in primary care and pediatric subspecialties. Children’s of Alabama, with its new Benjamin Russell Hospital for Children, had nearly 16,000 hospital discharges and >1 million outpatient visits in 2017.

    Cohen is a native of New York, N.Y., and completed medical school at Mount Sinai School of Medicine and pediatric residency training at Johns Hopkins. In 1983 he began a three-year fellowship in pediatric gastroenterology and nutrition at Children’s Hospital Medical Center in Cincinnati and joined the faculty of the University of Cincinnati College of Medicine as an instructor. He became director of the Division of Gastroenterology, Hepatology and Nutrition at Cincinnati Children’s Hospital Medical Center in 2005 and vice-chair of the Department of Pediatrics in 2009. From 2002 to 2004 he served as president of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition, and received the organization’s Shwachman Award in 2013 for lifelong scientific contributions.

    Cohen and his wife, Morissa Ladinsky Cohen, MD, also a pediatrician, have five children: Seth, Noah, Raphael, Andrew and Nicole
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2019 A Phase 1 dose escalating study of double mutant heat-labile toxin LTR192G/L211A (dmLT) from Enterotoxigenic Escherichia coli (ETEC) by sublingual or oral immunization 2019
    2018 Lipopolysaccharide-specific memory B cell responses to an attenuated live cholera vaccine are associated with protection against Vibrio cholerae infection 2018
    2018 Anti-O-specific polysaccharide (OSP) immune responses following vaccination with oral cholera vaccine CVD 103-HgR correlate with protection against cholera after infection with wild-type Vibrio cholerae O1 El Tor Inaba in North American volunteers 2018
    2018 Universal recommendations for the management of acute diarrhea in nonmalnourished children 2018
    2017 Risk Categorization Predicts Disability in Pain-associated Functional Gastrointestinal Disorders after 6 Months 2017
    2017 Rotavirus immunization: Global coverage and local barriers for implementation 2017
    2017 The live attenuated cholera vaccine CVD 103-HgR primes responses to the toxin-coregulated pilus antigen TcpA in subjects challenged with wild-type vibrio cholerae 2017
    2016 Update on diarrhea 2016
    2016 Comparison of recommendations in clinical practice guidelines for acute gastroenteritis in children 2016
    2016 Single-dose live oral cholera vaccine CVD 103-HgR protects against human experimental infection with vibrio cholerae O1 El Tor 2016
    2015 Current Issues in Transitioning from Pediatric to Adult-Based Care for Youth with Chronic Health Care Needs 2015
    2015 CNS, lung, and lymph node involvement in Gaucher disease type 3 after 11years of therapy: Clinical, histopathologic, and biochemical findings 2015
    2015 Concordant parent-child reports of anxiety predict impairment in youth with functional abdominal pain 2015
    2015 Safety and immunogenicity of escalating dosages of a single oral administration of peru-15 pCTB, a candidate live, attenuated vaccine against enterotoxigenic Escherichia coli and Vibrio cholerae 2015
    2014 Acid-reducing agents in infants and children: Friend or foe? 2014
    2014 Effect of guanylate cyclase-C activity on energy and glucose homeostasis 2014
    2014 Fecal microbiota transplantation for Clostridium difficile infection: Benefits and barriers 2014
    2014 Role of celiac disease screening for children with functional gastrointestinal disorders 2014
    2014 Safety and immunogenicity of a single oral dose of recombinant double mutant heat-labile toxin derived from enterotoxigenic Escherichia coli (Clinical and Vaccine Immunology (2013) 20, 11, (1764-1770)) 2014
    2013 Guanylate Cyclase C deficiency causes severe inflammation in a murine model of spontaneous colitis 2013
    2013 Safety and immunogenicity of a single oral dose of recombinant double mutant heat-labile toxin derived from enterotoxigenic Escherichia coli 2013
    2013 Guanylate cyclase C limits systemic dissemination of a murine enteric pathogen 2013
    2013 Acid suppression and the risk of clostridium difficile infection 2013
    2013 Importance of addressing anxiety in youth with functional abdominal pain: Suggested guidelines for physicians 2013
    2013 Linaclotide inhibits colonic nociceptors and relieves abdominal pain via guanylate cyclase-C and extracellular cyclic guanosine 3′,5′- monophosphate 2013
    2012 Recurrent pancreatitis in ornithine transcarbamylase deficiency 2012
    2011 STREM-1 and LBP in central venous catheter-associated bloodstream infections in pediatric intestinal failure 2011
    2011 Role for the membrane receptor guanylyl cyclase-C in attention deficiency and hyperactive behavior 2011
    2011 What have we learned about early treatment of Pseudomonas aeruginosa infection in infants and children with cystic fibrosis? 2011
    2011 Murine guanylate cyclase C regulates colonic injury and inflammation 2011
    2011 Clostridium difficile infection in hospitalized children in the United States 2011
    2011 Clostridium difficile infection and treatment in the pediatric inflammatory bowel disease population 2011
    2011 Transmembrane guanylate cyclase in intestinal pathophysiology 2011
    2011 Loss of guanylyl cyclase C (GCC) Signaling leads to dysfunctional intestinal barrier 2011
    2010 Lack of Guanylate Cyclase C results in increased mortality in mice following liver injury 2010
    2010 Linaclotide is a potent and selective guanylate cyclase C agonist that elicits pharmacological effects locally in the gastrointestinal tract 2010
    2010 Guanylate cyclase C-mediated antinociceptive effects of linaclotide in rodent models of visceral pain 2010
    2010 State of Research in Pediatric Gastroenterology, Hepatology, and Nutrition: 2010 and Beyond 2010
    2009 Teaching and tomorrow: A novel recruitment program for a pediatric subspecialty 2009
    2009 Activation of guanylate cyclase C signaling pathway protects intestinal epithelial cells from acute radiation-induced apoptosis 2009
    2009 Clostridium difficile infections: Emerging epidemiology and new treatments 2009
    2009 Editorial introductions 2009
    2008 Heat-stable enterotoxin of Escherichia coli (STa) can stimulate duodenal HCO 3- secretion via a novel GC-C- and CFTR-independent pathway 2008
    2008 Presentation of the 2007 Murray Davidson Award to Michael K. Farrell, MD 2008
    2007 Molecular cloning and promoter analysis of downregulated in adenoma (DRA) 2007
    2007 An Eosinophil Hypothesis for Functional Dyspepsia 2007
    2007 How safe is intravenous sedation with midazolam and fentanyl for pediatric gastrointestinal endoscopy? Commentary 2007
    2007 Suppurative peripheral arthritis in inflammatory bowel disease 2007
    2007 Novel mechanism of cyclic AMP mediated extracellular signal regulated kinase activation in an intestinal cell line 2007
    2007 Gaucher Disease: Progressive Mesenteric and Mediastinal Lymphadenopathy Despite Enzyme Therapy 2007
    2007 State of Pediatric Gastroenterology, Hepatology, and Nutrition: 2006 and Beyond 2007
    2006 Potential of Blood Eosinophils, Eosinophil-Derived Neurotoxin, and Eotaxin-3 as Biomarkers of Eosinophilic Esophagitis 2006
    2006 The Bacteroides fragilis toxin binds to a specific intestinal epithelial cell receptor 2006
    2006 Festschrift introduction 2006
    2006 The proximal convoluted tubule is a target for the uroguanylin-regulated natriuretic response 2006
    2006 Eotaxin-3 and a uniquely conserved gene-expression profile in eosinophilic esophagitis 2006
    2006 A Randomized, Double-Blind, Placebo-Controlled Trial of Fluticasone Propionate for Pediatric Eosinophilic Esophagitis 2006
    2005 Novel effects of the prototype translocating Escherichia coli, strain C25 on intestinal epithelial structure and barrier function 2005
    2005 Lack of guanylyl cyclase C, the receptor for Escherichia coli heat-stable enterotoxin, results in reduced polyp formation and increased apoptosis in the multiple intestinal neoplasia (Min) mouse model 2005
    2005 Prevalence and outcome of allergic colitis in healthy infants with rectal bleeding: A prospective cohort study 2005
    2005 National Institutes of Health Consensus Development Conference statement on Celiac Disease, June 28-30, 2004 2005
    2005 Presentation of the Julius M. Friedenwald Medal to Ralph A. Giannella, MD. 2005
    2005 Prevalence of diarrheagenic Escherichia coli in acute childhood enteritis: A prospective controlled study 2005
    2004 Cyclic AMP activation of the extracellular signal-regulated kinases 1 and 2: Implications for intestinal cell survival through the transient inhibition of apoptosis 2004
    2004 Effect of secretagogues and pH on intestinal transport in guanylin-deficient mice 2004
    2004 Duodenogastric Intussusception: A Rare Cause of Gastric Outlet Obstruction 2004
    2003 Effect of triglyceride structure on fecal excretion of 13c-labeled triglycerides 2003
    2003 Dysprosium chloride as a nonabsorbable gastrointestinal marker for studies of stable isotope-labeled triglyceride excretion in man 2003
    2003 Uroguanylin knockout mice have increased blood pressure and impaired natriuretic response to enteral NaCl load 2003
    2003 Uroguanylin knockout mice have increased blood pressure and impaired natriuretic response to enteral NaCl load. 2003
    2002 Coordinate upregulation of guanylin and uroguanylin expression by hypertonicity in HT29-18-N2 cells 2002
    2002 Coordinate upregulation of guanylin and uroguanylin expression by hypertonicity in HT29-18-N2 cells. 2002
    2002 Targeted inactivation of the mouse guanylin gene results in altered dynamics of colonic epithelial proliferation 2002
    2002 Research agenda for pediatric gastroenterology, hepatology and nutrition: Secretion and diarrhea - Report of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition for the Children's Digestive Health and Nutrition Foundation 2002
    2002 Proguanylin secretion and the role of negative-feedback inhibition in a villous epithelial cell line 2002
    2002 Proguanylin secretion and the role of negative-feedback inhibition in a villous epithelial cell line. 2002
    2002 Shiga toxin-producing E coli: Two tests are better than one 2002
    2002 Host-induced epidemic spread of the cholera bacterium 2002
    2002 Randomized, controlled human challenge study of the safety, immunogenicity, and protective efficacy of a single dose of Peru-15, a live attenuated oral cholera vaccine 2002
    2002 An estimate of the reliability of reference data on the electromagnetic properties of materials at high and microwave frequencies 2002
    2002 Implementing an evidence-based acute gastroenteritis guideline at a children's hospital. 2002
    2002 Novel genes and functional relationships in the adult mouse gastrointestinal tract identified by microarray analysis 2002
    2001 A human volunteer challenge model using frozen bacteria of the new epidemic serotype, V. cholerae O139 in Thai volunteers 2001
    2001 Strategic planning for NASPGN 2001
    2001 Increases in guanylin and uroguanylin in a mouse model of osmotic diarrhea are guanylate cyclase C-independent 2001
    2000 A duodenum-specific enhancer regulates expression along three axes in the small intestine 2000
    2000 A duodenum-specific enhancer regulates expression along three axes in the small intestine. 2000
    2000 Expression of guanylin is downregulated in mouse and human intestinal adenomas 2000
    2000 The Shwachman Award of the North American Society for Pediatric Gastroenterology and Nutrition, 1999: Presentation 2000
    2000 Erratum: The uroguanylin gene (Guca1b) is linked to guanylin (Guca2) on mouse chromosome 4 (Genomics (1997) 45:2 (348-354)) 2000
    2000 Gastrointestinal infections in children 2000
    1999 NASPGN guidelines for training in pediatric gastroenterology 1999
    1999 Randomized, double-blind, placebo-controlled, multicentered trial of the efficacy of a single dose of live oral cholera vaccine CVD 103-HgR in preventing cholera following challenge with Vibrio cholerae O1 El Tor Inaba three months after vaccination 1999
    1999 Validation and characterization of a human volunteer challenge model for cholera by using frozen bacteria of the new Vibrio cholerae epidemic serotype, O139 1999
    1999 Our new president-ralph A. Giannella, M.D 1999
    1999 Food-borne and water-borne infections and the gastroenterologist 1999
    1999 New causes and treatments for infectious diarrhea in children. 1999
    1998 Controversies in pediatric inflammatory bowel disease 1998
    1998 Validation of a volunteer model of cholera with frozen bacteria as the challenge 1998
    1998 Escherichia coli O157:H7: Assessing and minimizing the risk from farm to fork 1998
    1998 Exacerbation of autoimmune hepatitis: Another hepatotoxic effect of pemoline therapy 1998
    1998 Guanylin mRNA expression in human intestine and colorectal adenocarcinoma 1998
    1997 Hepatocyte nuclear factor-1α regulates transcription of the guanylin gene 1997
    1997 Hepatocyte nuclear factor-1α regulates transcription of the guanylin gene. 1997
    1997 The heat-stable enterotoxin-guanylin receptor is expressed in rat hepatocytes and in a rat hepatoma (H-35) cell line 1997
    1997 The uroguanylin gene (Guca1b) is linked to guanylin (Guca2) on mouse chromosome 4 1997
    1997 Uroguanylin and guanylin: Distinct but overlapping patterns of messenger RNA expression in mouse intestine 1997
    1996 Diagnosis of cytomegalovirus infection in pediatric Menetrier's disease by in situ hybridization 1996
    1996 Outpatient liver biopsy in children: A medical position statement of the North American Society for Pediatric Gastroenterology and Nutrition 1996
    1996 Escherichia coli O157:H7 infections: a frequent cause of bloody diarrhea and the hemolytic-uremic syndrome. 1996
    1996 Hnf1α regulates guanylin expression.: Fellow research award winnerl 1996
    1996 Infectious gastroenterocolitides in children: An update on emerging pathogens 1996
    1995 Evaluation and Management of the Adolescent with Infectious Diarrhea. 1995
    1995 A selective advantage for cystic fibrosis carriers 1995
    1995 Colonic inflections, including those in the immunosuppressed host 1995
    1995 Immunohistochemical localization of guanylin in the rat small intestine and colon 1995
    1995 Mapping of guanylin to murine chromosome 4 and human chromosome 1p34-p35 1995
    1995 Use of a single solution for oral rehydration and maintenance therapy of infants with diarrhea and mild to moderate dehydration 1995
    1995 Wherefore art thou guanylin? 1995
    1994 Diarrheal disease - Established pathogens, new pathogens, and progress in vaccine development 1994
    1994 Upregulation of Escherichia coli heat-stable enterotoxin receptor in regenerating rat liver. 1994
    1994 Genomic sequence of the murine guanylin gene 1994
    1994 Prevention of Travelers' Diarrhea: Ciprofloxacin versus Trimethoprim/Sulfamethoxazole in Adult Volunteers Working in Latin America and the Caribbean 1994
    1994 Upregulation of Escherichia coli heat-stable enterotoxin receptor in regenerating rat liver 1994
    1993 Guanylin mRNA is expressed in villous enterocytes of the rat small intestine and superficial epithelia of the rat colon 1993
    1993 Medicaid Coverage of Oral Rehydration Solutions 1993
    1993 Approach to the pediatric patient with diarrhea 1993
    1993 Colonization by enteroaggregative Escherichia coli in travelers with and without diarrhea 1993
    1993 Comparison of receptors for Escherichia coli heat-stable enterotoxin: Novel receptor present in IEC-6 cells 1993
    1993 Gastrointestinal infection in children 1993
    1993 Intracranial hemorrhage due to vitamin K deficiency in breast-fed infants with cholestasis 1993
    1993 Receptors for Escherichia coli heat stable enterotoxin in human intestine and in a human intestinal cell line (Caco‐2) 1993
    1993 Traveler's diarrhea 1993
    1992 Novel sites for expression of an Escherichia coli heat-stable enterotoxin receptor in the developing rat. 1992
    1992 A gradient in expression of the escherichia coli heat-stable enterotoxin receptor exists along the villus-to-crypt axis of rat small intestine 1992
    1992 Complications of percutaneous liver biopsy in children 1992
    1992 Escherichia coli enterotoxin (STa) binds to receptors, stimulates guanyl cyclase, and Impairs absorption in rat colon 1992
    1992 Hemorrhagic colitis associated with Escherichia coli O157:H7. 1992
    1992 Jejunal toxin inactivation regulates susceptibility of the immature rat to STa 1992
    1992 Novel sites for expression of an Escherichia coli heat-stable enterotoxin receptor in the developing rat 1992
    1992 The heat-stable enterotoxin receptor: a probe for ligand hunting. 1992
    1992 The jejunal secretory response to Escherichia coli heat-stable enterotoxin is prolonged in malnourished rats 1992
    1991 Discussion I 1991
    1991 Etiology and mechanisms of acute infectious diarrhea in infants in the United States 1991
    1991 Mechanisms of increased susceptibility of immature and weaned pigs to escherichia coli heat-stable enterotoxin 1991
    1990 Diagnosis and management of acute diarrhea in children 1990
    1990 Crohn disease in an infant with central nervous system thrombosis and protein-losing enteropathy 1990
    1989 Differences in jejunal and ileal response to E. coli enterotoxin: Possible mechanisms 1989
    1988 Age-related differences in receptors for Escherichia coli heat-stable enterotoxin in the small and large intestine of children 1988
    1987 T84 cell receptor binding and guanyl cyclase activation by Escherichia coli heat-stable toxin. 1987
    1987 Binding of E. coli heat-stable enterotoxin to rat intestinal brush borders and to basolateral membranes 1987
    1987 Association and dissociation of Escherichia coli heat-stable enterotoxin from rat brush border membrane receptors 1987
    1987 Small and large intestinal guanylate cyclase activity in children: Effect of age and stimulation by escherichia coli heat-stable enterotoxin 1987
    1987 T84 cell receptor binding and guanyl cyclase activation by Escherichia coli heat-stable toxin 1987
    1986 The immature rat small intestine exhibits an increased sensitivity and response to Escherichia Coli heat-stable enterotoxin 1986

    Chapter

    Year Title Altmetric
    2011 Infectious Diarrhea.  405-422. 2011
    2006 Infectious Diarrhea.  557-581. 2006

    Research Overview

  • diarrheal diseases
  • Principal Investigator On

  • Private Grant  awarded by IRONWOOD PHARMACEUTICALS, INC. 2015 - 2017
  • Education And Training

  • Johns Hopkins Hospital, Internship 1978
  • Johns Hopkins Hospital, Residency 1980
  • Cincinnati Children's Medical Center, Postdoctoral Fellowship 1986
  • Full Name

  • Mitchell Cohen