Positions

Selected Publications

Academic Article

Year Title Altmetric
2018 Corrigendum to "Deficits in synaptic function occur at medial perforant path-dentate granule cell synapses prior to Schaffer collateral-CA1 pyramidal cell synapses in the novel TgF344-Alzheimer's Disease Rat Model" [Neurobiology of Disease Volume 110, February 2018, Pages 166-179].Neurobiology of Disease.  118:177-178. 2018
2018 Disinhibition of CA1 pyramidal cells by low-dose ketamine and other antagonists with rapid antidepressant efficacy.Proceedings of the National Academy of Sciences.  115:E3007-E3016. 2018
2018 Deficits in synaptic function occur at medial perforant path-dentate granule cell synapses prior to Schaffer collateral-CA1 pyramidal cell synapses in the novel TgF344-Alzheimer's Disease Rat Model.Neurobiology of Disease.  110:166-179. 2018
2018 Intravascular Ketamine Increases Theta-Burst but Not High Frequency Tetanus Induced LTP at CA3-CA1 Synapses Within Three Hours and Devoid of an Increase in Spine Density.Frontiers in Synaptic Neuroscience.  10:8. 2018
2017 Acute Increases in Protein O-GlcNAcylation Dampen Epileptiform Activity in Hippocampus.Journal of Neuroscience.  37:8207-8215. 2017
2017 O-GlcNAcylation and neurodegeneration.Brain Research Bulletin.  133:80-87. 2017
2017 Strength of cholinergic tone dictates the polarity of dopamine D2 receptor modulation of striatal cholinergic interneuron excitability in DYT1 dystonia.Experimental Neurology.  295:162-175. 2017
2017 GSK3 activity regulates rhythms in hippocampal clock gene expression and synaptic plasticity.Hippocampus.  27:890-898. 2017
2017 Vitamin A and retinoic acid combination attenuates neonatal hyperoxia-induced neurobehavioral impairment in adult mice.Neurobiology of Learning and Memory.  141:209-216. 2017
2016 17β estradiol recruits GluN2B-containing NMDARs and ERK during induction of long-term potentiation at temporoammonic-CA1 synapses.Hippocampus.  26:110-117. 2016
2014 Tau-mediated NMDA receptor impairment underlies dysfunction of a selectively vulnerable network in a mouse model of frontotemporal dementia.Journal of Neuroscience.  34:16482-16495. 2014
2014 An acetylcholinesterase inhibitor, eserine, induces long-term depression at CA3-CA1 synapses in the hippocampus of adult rats.Journal of Neurophysiology.  112:2388-2397. 2014
2014 Estradiol replacement extends the window of opportunity for hippocampal function.Neurobiology of Aging.  35:2183-2192. 2014
2014 Increased long-term potentiation at medial-perforant path-dentate granule cell synapses induced by selective inhibition of histone deacetylase 3 requires Fragile X mental retardation protein.Neurobiology of Learning and Memory.  114:193-197. 2014
2014 Simvastatin treatment enhances NMDAR-mediated synaptic transmission by upregulating the surface distribution of the GluN2B subunit.Cellular and Molecular Neurobiology.  34:693-705. 2014
2014 17β Estradiol increases resilience and improves hippocampal synaptic function in helpless ovariectomized rats.Psychoneuroendocrinology.  42:77-88. 2014
2014 Glycogen synthase kinase-3 inhibitors reverse deficits in long-term potentiation and cognition in fragile X mice.Biological Psychiatry.  75:198-206. 2014
2014 Noradrenergic sympathetic sprouting and cholinergic reinnervation maintains non-amyloidogenic processing of AβPP.Journal of Alzheimer's Disease.  38:867-879. 2014
2014 O-GlcNAcylation of AMPA receptor GluA2 is associated with a novel form of long-term depression at hippocampal synapses.Journal of Neuroscience.  34:10-21. 2014
2013 Estradiol-induced increase in novel object recognition requires hippocampal NR2B-containing NMDA receptors.Hippocampus.  23:108-115. 2013
2012 G9a/GLP histone lysine dimethyltransferase complex activity in the hippocampus and the entorhinal cortex is required for gene activation and silencing during memory consolidation.Journal of Neuroscience.  32:5440-5453. 2012
2012 Simvastatin-mediated enhancement of long-term potentiation is driven by farnesyl-pyrophosphate depletion and inhibition of farnesylation.Neuroscience.  202:1-9. 2012
2010 Sympathetic sprouting in visual cortex stimulated by cholinergic denervation rescues expression of two forms of long-term depression at layer 2/3 synapses.Neuroscience.  168:591-604. 2010
2010 Simvastatin enhances hippocampal long-term potentiation in C57BL/6 mice.Neuroscience.  166:435-444. 2010
2009 Estradiol and the relationship between dendritic spines, NR2B containing NMDA receptors, and the magnitude of long-term potentiation at hippocampal CA3-CA1 synapses.Psychoneuroendocrinology.  34 Suppl 1:S130-S142. 2009
2008 Layer 2/3 synapses in monocular and binocular regions of tree shrew visual cortex express mAChR-dependent long-term depression and long-term potentiation.Journal of Neurophysiology.  100:336-345. 2008
2008 Coactivation of M(1) muscarinic and alpha1 adrenergic receptors stimulates extracellular signal-regulated protein kinase and induces long-term depression at CA3-CA1 synapses in rat hippocampus.Journal of Neuroscience.  28:5350-5358. 2008
2007 Muscarinic receptor dependent long-term depression in rat visual cortex is PKC independent but requires ERK1/2 activation and protein synthesis.Journal of Neurophysiology.  98:1862-1870. 2007
2006 Coexistence of muscarinic long-term depression with electrically induced long-term potentiation and depression at CA3-CA1 synapses.Journal of Neurophysiology.  96:3114-3121. 2006
2006 Estradiol-induced increase in the magnitude of long-term potentiation is prevented by blocking NR2B-containing receptors.Journal of Neuroscience.  26:8517-8522. 2006
2006 Sympathetic sprouting drives hippocampal cholinergic reinnervation that prevents loss of a muscarinic receptor-dependent long-term depression at CA3-CA1 synapses.Journal of Neuroscience.  26:3745-3756. 2006
2006 Glycine-gated chloride channels depress synaptic transmission in rat hippocampus.Journal of Neurophysiology.  95:2366-2379. 2006
2005 Estrogen-induced increase in the magnitude of long-term potentiation occurs only when the ratio of NMDA transmission to AMPA transmission is increased.Journal of Neuroscience.  25:7780-7791. 2005
2004 Novel form of long-term synaptic depression in rat hippocampus induced by activation of alpha 1 adrenergic receptors.Journal of Neurophysiology.  91:1071-1077. 2004
2003 Immunolocalization of the acid-sensing ion channel 2a in the rat cerebellum.Histochemistry and Cell Biology.  119:437-446. 2003
2003 Strychnine-sensitive glycine receptors depress hyperexcitability in rat dentate gyrus.Journal of Neurophysiology.  89:1339-1342. 2003
2002 Pharmacological characterization of glycine-gated chloride currents recorded in rat hippocampal slices.Journal of Neurophysiology.  87:1515-1525. 2002
1994 Nicotinic receptor activation facilitates GABAergic neurotransmission in the avian lateral spiriform nucleus.Neuroscience.  59:689-698. 1994
1993 Different responses to opioids measured in terminals and somas of Edinger-Westphal neurons.Neuroscience.  57:425-432. 1993
1991 The cannabinoid receptor: biochemical and cellular properties in neuroblastoma cells.Pharmacology Biochemistry and Behavior.  40:565-569. 1991

Principal Investigator On

  • RII Track-2 FEC: The Creation of Next Generation Tools for Neuroscience - Noninvasive Radioluminescence Approaches to Optogenetics  awarded by Clemson University 2016 - 2020
  • UAB Neuroscience Roadmap Scholars Program  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2014 - 2019
  • Impact of Estrogen Loss and Replacement on GLuN2B containing NMDAR's, Synaptic Plasticity, and Learning and Memory in Females using a Novel Transgenic Rat Model of Alzheimer's Disease  awarded by National Institute on Aging/NIH/DHHS 2016 - 2019
  • 17-Beta-Estradiol Protects Critical Hippocampal Synaptic Circuits During Asymptomatic Disease in the Novel TgF344-AD rat  awarded by National Institute on Aging/NIH/DHHS 2017 - 2019
  • Effects off NMDAR Antagonist on Hippocampal Circuits  awarded by National Institute of Mental Health/NIH/DHHS 2016 - 2018
  • Interactions of 17beta Estradiol and Ketamine on Depression-Like Behavior, Hippocampal Synaptic Function, and Cognition in Ovariectomized Rats  awarded by National Institute of Mental Health/NIH/DHHS 2016 - 2018
  • O-GlcNAcylation Dampens Hyperexcitability in Hippocampus during Acute Epileptiform Activity  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2015 - 2017
  • O-GlcNAcylation and Hippocampal Synaptic Plasticity  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2011 - 2017
  • Muscarinic Receptor Induced LTD in Rat Hippocampus  awarded by National Institute on Aging/NIH/DHHS 2011 - 2016
  • The Role of GSK3 in Synaptic and Cognitive Deficits in Fragile X Syndrome  awarded by National Institute of Mental Health/NIH/DHHS 2012 - 2014
  • Estrogen and Hippocampal Plasticity  awarded by National Institute of Mental Health/NIH/DHHS 2008 - 2014
  • O-Linked Glycosylation and Synaptic Function in Hippocampus  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2009 - 2012
  • Protective Mechanisms of Statins in Alzheimer's Disease  awarded by University of Minnesota 2010 - 2012
  • The Role of O-GlcNAcylation in Synaptic Function  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2010 - 2012
  • Sympathetic Sprouting in Human AD Hippocampus: A Potential Novel Therapeutic Target  awarded by ALZHEIMER'S OF CENTRAL ALABAMA 2010 - 2011
  • Learned Helplessness, Estrogen, and Hippocampal Synaptic Function  awarded by National Alliance for Research on Schizophrenia and Depression 2008 - 2011
  • Muscarinic Receptor Induced LTD in Rat Hippocampus  awarded by National Institute on Aging/NIH/DHHS 2004 - 2010
  • Investigator On

  • Training Program in the Neurobiology of Cognition and Cognitive Disorders  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2018 - 2023
  • BIN1, Interneuron Activity, and Network Dysfunction in Alzheimer Disease  awarded by National Institute on Aging/NIH/DHHS 2018 - 2023
  • Circadian Dysfunction and Neurodegenerative Disease  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2018 - 2023
  • UAB Training Program in Neuroscience  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2017 - 2022
  • NF-kB Methyl-Lysine Signaling in the Epigenetic Regulation of Memory  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2017 - 2020
  • Role of Alpha Synuclein in PINK1-linked Parkinson's Disease  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2018 - 2020
  • Regulation of Novel Alpha2A Adrenergic Receptor Signaling by Spinophilin  awarded by National Institute of Mental Health/NIH/DHHS 2015 - 2020
  • Molecular Etiology of Early Onset Torsion Dystonia  awarded by MASSACHUSETTS GENERAL HOSPITAL 2015 - 2020
  • Effects of NPY on Hippocampal Circuit Function  awarded by National Institute of Mental Health/NIH/DHHS 2015 - 2020
  • CRISPR/dCas9-targeted Manipulation of bdnf Transcription in Synaptic Plasticity and Contextual Learning  awarded by National Institute of Mental Health/NIH/DHHS 2016 - 2020
  • Frequency-dependent Modulation of Synaptic Transmission and Plasticity by pH  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2016 - 2019
  • UAB Center for Clinical and Translational Science (CCTS) (3 Linked Awards UL1, KL2, TL1)  awarded by National Center for Advancing Translational Sciences/NIH/DHHS 2015 - 2019
  • Mechanisms by Which Retinoids Attenuate Hyperoxia-Induced Memory Deficit in Mice  awarded by KAUL PEDIATRIC RESEARCH INSTITUTE 2016 - 2018
  • Circadian Dysfunction and GSK3 in Neurodegenerative Disease  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2013 - 2018
  • UAB Research and Education Program in Neurology, Neurosurgery, and Neuropathology  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2012 - 2017
  • Ozone, ApoE4, Aging, and Alzheimer's Disease  awarded by National Institute on Aging/NIH/DHHS 2013 - 2016
  • Training Program in the Neurobiology of Cognition and Cognitive Disorders  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2013 - 2016
  • Tau and Glutamatergic Synapses in Frontotemporal Dementia  awarded by National Institute on Aging/NIH/DHHS 2013 - 2016
  • Glucose Metabolism and Insulin Sensitivity in Depressed Patients following Early Life Stress  awarded by Brain and Behavior Research Foundation 2014 - 2016
  • GIRK Channel Modulation of SCN Excitability and Circadian Rhythms  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2014 - 2015
  • Teaching Activities

  • GRD706 - Grants and Fellowships 101 (Fall Term 2018) 2018
  • GRD746 - Crit Dec in Mentoring & Lead (Summer Term 2018) 2018
  • GRD719 - Intro Mentoring & Leadership (Spring Term 2018) 2018
  • NBL745 - Prof Dev Course (Spring Term 2018) 2018
  • GRD706 - Grants and Fellowships 101 (Fall Term 2017) 2017
  • GRD719 - Intro Mentoring & Leadership (Fall Term 2017) 2017
  • NBL723 - Experimental Design (Fall Term 2017) 2017
  • NBL741 - Writing and Presenting (Fall Term 2017) 2017
  • NBL791 - Crit Thinking/Analytical Skill (Fall Term 2017) 2017
  • NBL741 - Writing and Presenting (Spring Term 2017) 2017
  • NBL745 - Prof Dev Course (Spring Term 2017) 2017
  • GRD706 - Grants and Fellowships 101 (Fall Term 2016) 2016
  • GRD719 - Intro Mentoring & Leadership (Fall Term 2016) 2016
  • GRD719 - Intro Mentoring & Leadership (Summer Term 2016) 2016
  • NBL723 - Experimental Design (Fall Term 2015) 2015
  • NBL791 - Crit Thinking/Analytical Skill (Fall Term 2015) 2015
  • VIS729 - Intro to Neurobio/Marine Bio (Fall Term 2015) 2015
  • VIS729 - Intro to Neurobio/Marine Bio (Fall Term 2014) 2014
  • VIS729 - Intro to Neurobio/Marine Bio (Fall Term 2013) 2013
  • VIS729 - Intro to Neurobio/Marine Bio (Fall Term 2012) 2012
  • VIS729 - Intro to Neurobio/Marine Bio (Summer Term 2012) 2012
  • PHY787 - Electronics in Physiology (Summer Term 2011) 2011
  • VIS729 - Intro to Neurobio/Marine Bio (Summer Term 2011) 2011
  • NEUR717 - Lab Rotation III (Summer Term 2010) 2010
  • NEUR782 - Student Summer Seminar Series (Summer Term 2010) 2010
  • NEUR798 - Nondissertation Research (Summer Term 2010) 2010
  • NEUR799 - Dissertation Research (Summer Term 2010) 2010
  • NEUR716 - Lab Rotation II (Spring Term 2010) 2010
  • NEUR798 - Nondissertation Research (Spring Term 2010) 2010
  • NEUR799 - Dissertation Research (Spring Term 2010) 2010
  • NEUR714 - Princ Cell Neuro Sci Module IV (Fall Term 2009) 2009
  • NEUR715 - Lab Rotation I (Fall Term 2009) 2009
  • NEUR798 - Nondissertation Research (Fall Term 2009) 2009
  • NEUR799 - Dissertation Research (Fall Term 2009) 2009
  • NEUR717 - Lab Rotation III (Summer Term 2009) 2009
  • NEUR782 - Student Summer Seminar Series (Summer Term 2009) 2009
  • NEUR798 - Nondissertation Research (Summer Term 2009) 2009
  • NEUR716 - Lab Rotation II (Spring Term 2009) 2009
  • NEUR781 - Seminar II Tpc Neurosci Res (Spring Term 2009) 2009
  • NEUR798 - Nondissertation Research (Spring Term 2009) 2009
  • NEUR714 - Princ Cell Neuro Sci Module IV (Fall Term 2008) 2008
  • NEUR715 - Lab Rotation I (Fall Term 2008) 2008
  • NEUR798 - Nondissertation Research (Fall Term 2008) 2008
  • PHY787 - Electronics in Physiology (Fall Term 2008) 2008
  • NEUR717 - Lab Rotation III (Summer Term 2008) 2008
  • NEUR782 - Student Summer Seminar Series (Summer Term 2008) 2008
  • NEUR798 - Nondissertation Research (Summer Term 2008) 2008
  • NEUR716 - Lab Rotation II (Spring Term 2008) 2008
  • NEUR781 - Seminar II Tpc Neurosci Res (Spring Term 2008) 2008
  • NEUR798 - Nondissertation Research (Spring Term 2008) 2008
  • NEUR714 - Princ Cell Neuro Sci Module IV (Fall Term 2007) 2007
  • NEUR715 - Lab Rotation I (Fall Term 2007) 2007
  • NEUR717 - Lab Rotation III (Fall Term 2007) 2007
  • NEUR798 - Nondissertation Research (Fall Term 2007) 2007
  • NEUR798 - Nondissertation Research (Fall Term 2007) 2007
  • Education And Training

  • Doctor of Philosophy in Neuropharmacology, Saint Louis University
  • Full Name

  • Lori McMahon Wakefield
  • Blazerid

  • mcmahon