Positions

Selected Publications

Academic Article

Year Title Altmetric
2014 Changing the academic culture: Valuing patents and commercialization toward tenure and career advancement 2014
2014 Stromal interaction molecule 1 is essential for normal cardiac homeostasis through modulation of ER and mitochondrial function 2014
2014 O-GlcNAcylation of AMPA receptor GluA2 is associated with a novel form of long-term depression at hippocampal synapses 2014
2013 STIM1/Orai1-mediated SOCE: Current perspectives and potential roles in cardiac function and pathology 2013
2012 Modification of STIM1 by O-linked N-Acetylglucosamine (O-GlcNAc) attenuates store-operated calcium entry in neonatal cardiomyocytesJournal of Biological Chemistry.  287:39094-39106. 2012
2012 Glucose deprivation-induced increase in protein O-GlcNAcylation in cardiomyocytes is calcium-dependentJournal of Biological Chemistry.  287:34419-34431. 2012
2011 Better regulation for research universitiesIssues in science and technology.  28:13-18. 2011
2010 The role of protein O-linked β-N-acetylglucosamine in mediating cardiac stress responses 2010
2010 Increased O-linked β-N-acetylglucosamine levels on proteins improves survival, reduces inflammation and organ damage 24 hours after trauma-hemorrhage in ratsCritical Care Medicine.  38:562-571. 2010
2010 Protein O-GlcNAcylation: A critical regulator of the cellular response to stressCurrent Signal Transduction Therapy.  5:49-59. 2010
2009 Glucosamine improves cardiac function following trauma-hemorrhage by increased protein O-GlcNAcylation and attenuation of NF-κB signaling 2009
2008 Erratum: Peritransplant tolerance induction in macaques: Early events reflecting the unique synergy between immunotoxin and deoxyspergualin (Transplantation (1999) 68:11 (1660-1673))Transplantation.  86:482. 2008
2008 Erratum: Tolerability and side effects of anti-CD3-immunotoxin in preclinical testing in kidney and pancreatic islet transplant recipients (Transplantation (1999) 68:2 (215-219))Transplantation.  86:482. 2008
2008 Glucosamine protects neonatal cardiomyocytes from ischemia-reperfusion injury via increased protein O-GlcNAc and increased mitochondrial Bcl-2 2008
2008 Hexosamine biosynthesis and protein O-glycosylation: The first line of defense against stress, ischemia, and traumaShock.  29:431-440. 2008
2008 Overexpression of TRPC3 increases apoptosis but not necrosis in response to ischemia-reperfusion in adult mouse cardiomyocytes 2008
2008 Aging leads to increased levels of protein O-linked N-acetylglucosamine in heart, aorta, brain and skeletal muscle in Brown-Norway ratsBiogerontology.  9:139-151. 2008
2007 Glucosamine administration improves survival rate after severe hemorrhagic shock combined with trauma in ratsShock.  28:345-352. 2007
2007 Increased O-GlcNAc levels during reperfusion lead to improved functional recovery and reduced calpain proteolysis 2007
2007 Glucosamine cardioprotection in perfused rat hearts associated with increased O-linked N-acetylglucosamine protein modification and altered p38 activation 2007
2007 Impact of Type 2 diabetes and aging on cardiomyocyte function and O-linked N-acetylglucosamine levels in the heart 2007
2007 The protective effects of PUGNAc on cardiac function after trauma-hemorrhage are mediated via increased protein O-GlcNAc levelsShock.  27:402-408. 2007
2007 Role of protein O-linked N-acetyl-glucosamine in mediating cell function and survival in the cardiovascular systemCardioscience.  73:288-297. 2007
2007 Glucosamine protects neonatal cardiomyocytes from ischemia-reperfusion injury via increased protein-associated O-GlcNAc 2007
2007 Glutamine-induced protection of isolated rat heart from ischemia/reperfusion injury is mediated via the hexosamine biosynthesis pathway and increased protein O-GlcNAc levelsJournal of Molecular and Cellular Cardiology.  42:177-185. 2007
2006 Glucosamine administration during resuscitation improves organ function after trauma hemorrhageShock.  25:600-607. 2006
2006 Increased hexosamine biosynthesis and protein O-GlcNAc levels associated with myocardial protection against calcium paradox and ischemiaJournal of Molecular and Cellular Cardiology.  40:303-312. 2006
2006 Glucosamine inhibits angiotensin II-induced cytoplasmic Ca2+ elevation in neonatal cardiomyocytes via protein-associated O-linked N-acetylglucosamine 2006
2005 A store-operated nonselective cation channel in human lymphocytesCellular and Molecular Neurobiology.  25:625-647. 2005
2005 Protein O-GlcNAc modulates motility-associated signaling intermediates in neutrophilsJournal of Biological Chemistry.  280:14579-14585. 2005
2004 Neutrophils exhibit rapid agonist-induced increases in protein-associated O-GlcNAcJournal of Biological Chemistry.  279:45759-45765. 2004
2004 Hexosamine Pathway Is Responsible for Inhibition by Diabetes of Phenylephrine-Induced InotropyDiabetes.  53:1074-1081. 2004
2004 Adult rat cardiomyocytes exhibit capacitative calcium entry 2004
2004 Ca2+ Modulation of Ca2+ Release-Activated Ca 2+ Channels Is Responsible for the Inactivation of Its Monovalent Cation CurrentBiophysical Journal.  86:805-814. 2004
2003 Regulation of Ca2+ release-activated Ca2+ channels by INAD and Ca2+ influx factor 2003
2002 Hyperglycemia inhibits capacitative calcium entry and hypertrophy in neonatal cardiomyocytesDiabetes.  51:3461-3467. 2002
2002 Calnexin is associated with and induced by overexpressed human complement protein C2Anatomical Record.  267:7-16. 2002
2002 Capacitative calcium entry contributes to nuclear factor of activated T-cells nuclear translocation and hypertrophy in cardiomyocytesJournal of Biological Chemistry.  277:14266-14273. 2002
2001 A store-operated nonselective cation channel in lymphocytes is activated directly by CA2+ influx factor and diacylglycerol 2001
2000 Calcium influx factor directly activates store-operated cation channels in vascular smooth muscle cellsJournal of Biological Chemistry.  275:26158-26163. 2000
2000 Preparation and use of a photoactivatable glucose-6-phosphate analogueBioorganic and Medicinal Chemistry Letters.  10:535-539. 2000
2000 Loss of the major isoform of phosphoglucomutase results in altered calcium homeostasis in Saccharomyces cerevisiaeJournal of Biological Chemistry.  275:5431-5440. 2000
2000 Measuring Contributions to the Research Mission of Medical SchoolsAcademic Medicine.  75:304-313. 2000
1999 The inhibition of capacitative calcium entry due to ATP depletion but not due to glucosamine is reversed by staurosporineJournal of Biological Chemistry.  274:20165-20170. 1999
1999 Efficient endocytosis of the cystic fibrosis transmembrane conductance regulator requires a tyrosine-based signalJournal of Biological Chemistry.  274:3602-3609. 1999
1999 Calcium influx factor is synthesized by yeast and mammalian cells depleted of organellar calcium stores 1999
1998 Glucose-6-phosphate and Ca2+ sequestration are mutually enhanced in microsomes from liver, brain, and heartDiabetes.  47:874-881. 1998
1997 Inhibition of capacitative Ca2+ entry by monosaccharides in J774 macrophages 1997
1996 A role for the glucose-6-phosphatase system in intracellular regulation of Ca2+ in J774 macrophages 1996
1996 Permeability to multivalent anions enhances calcuim (Ca2+) sequestration by rat cardiac microsomes 1996
1996 Down-regulation of secretion of human complement component C2 by the product of an alternatively spliced C2 messenger RNAJournal of Immunology.  156:4901-4908. 1996
1996 Regulation of intracellular calcium is closely linked to glucose metabolism in J774 macrophagesCell Calcium.  20:361-371. 1996
1995 Hyperglycemia alters cytoplasmic Ca2+ responses to capacitative Ca2+ influx in rat aortic smooth muscle cellsAmerican Journal of Physiology.  269. 1995
1995 The posttranslational modification of phosphoglucomutase is regulated by galactose induction and glucose repression in Saccharomyces cerevisiaeJournal of Bacteriology.  177:3087-3094. 1995
1994 The glycosylation of phosphoglucomutase is modulated by carbon source and heat shock in Saccharomyces cerevisiaeJournal of Biological Chemistry.  269:27143-27148. 1994
1994 Rapid endocytosis of the cystic fibrosis transmembrane conductance regulator chloride channel 1994
1994 Role of NO production in NMDA receptor-mediated neurotransmitter release in cerebral cortexScience.  263:973-977. 1994
1994 The Addition of Glucose‐1‐Phosphate to the Cytoplasmic Glycoprotein Phosphoglucomutase Is Modulated by Intracellular Calcium in PC12 Cells and Rat Cortical SynaptosomesJournal of Neurochemistry.  62:456-464. 1994
1993 Isolation and expression of a rat liver cDNA encoding phosphoglucomutaseGene.  133:261-266. 1993
1993 Glycogen contains phosphodiester groups that can be introduced by UDPglucose:glycogen glucose 1-phosphotransferaseFEBS Letters.  329:263-267. 1993
1993 Cell surface labeling of CFTR in T84 cellsAmerican Journal of Physiology.  264. 1993
1993 Phosphoglucomutase in Saccharomyces cerevisiae is a cytoplasmic glycoprotein and the acceptor for a Glc-phosphotransferaseJournal of Biological Chemistry.  268:8341-8349. 1993
1992 Gangliosides as modulators of cell functionAmerican Journal of Physiology.  262. 1992
1992 Identification of a membrane protein from T84 cells using antibodies made against a DIDS-binding peptideAmerican Journal of Physiology.  262. 1992
1991 β-phosphorothioate analogs of nucleotide sugars are resistant to hydrolytic degradation and utilized efficiently by glycosyltransferasesAnalytical Biochemistry.  197:40-46. 1991
1991 Receptor synthesis and routing to the plasma membraneAmerican Journal of the Medical Sciences.  302:238-243. 1991
1990 Parafusin, an exocytic-sensitive phosphoprotein, is the primary acceptor for the glucosylphosphotransferase in Paramecium tetraurelia and rat liver 1990
1990 Relative accessibility of N-acetylglucosamine in trimers of the adenovirus types 2 and 5 fiber proteinsJournal of Virology.  64:5317-5323. 1990
1990 Resolution of phosphoglucomutase and the 62-kDA acceptor for the glucosylphosphotransferaseMolecular cell biology research communications : MCBRC.  280:122-129. 1990
1989 An α-glucose-1-phosphate phosphodiesterase is present in rat liver cytosolJournal of Biological Chemistry.  264:20540-20546. 1989
1988 Cell surface expression of 4β‐galactosyltransferase accompanies rat parotid gland acinar cell transition to growthJournal of Cellular Biochemistry.  36:453-465. 1988
1988 Localization of the glucose phosphotransferase to a cytoplasmically accessible site on intracellular membranes.Journal of Biological Chemistry.  263:17792-17797. 1988
1987 Glucose-1-phosphate containing glycoproteins and interneuronal adhesionIntegrative and Comparative Biology.  27:179-187. 1987
1987 The β-phosphoro[35S]thioate analogue of UDP-Glc is efficiently utilized by the glucose phosphotransferase and is relatively resistant to hydrolytic degradation 1987
1987 Glucose-1-phosphotransferase and N-acetylglucosamine-1-phosphotransferase have distinct acceptor specificitiesJournal of Biological Chemistry.  262:4377-4381. 1987
1987 Isoproterenol-mediated parotid gland hypertrophy is inhibited by effectors of 4β-galactosyltransferaseJournal of Biological Chemistry.  262:11706-11713. 1987
1986 Glucose phosphotransferase and intracelular trafficking 1986
1984 Ontogeny of the basal lamina in the sea urchin embryoDevelopmental Biology.  103:235-245. 1984
1984 Phosphoglucose-containing glycoproteins in intracellular trafficking and neuronal recognition.Advances in Experimental Medicine and Biology.  181:161-173. 1984
1984 Three peptides recognizing mannose-6-phosphate-α1-glucose 1984
1982 A Possible Role for Ligatin and the Phosphoglycoproteins It Binds in Calcium‐Dependent Retinal Cell AdhesionJournal of Cellular Biochemistry.  18:461-468. 1982
1982 A UDP-glucose:Glycoprotein glucose-1-phosphotransferase in embryonic chicken neural retinaCell.  31:739-748. 1982
1982 Brain Ligatin: A Membrane Lectin That Binds AcetylcholinesteraseJournal of Cellular Biochemistry.  18:447-459. 1982
1982 Calcium‐Dependent and Calcium‐Independent Adhesive Mechanisms Are Present During Initial Binding Events of Neural Retina CellsJournal of Cellular Biochemistry.  18:469-478. 1982
1982 Retinal ligatin recognizes glycoproteins bearing oligosaccharides terminating in phosphodiester-linked glucoseCell.  28:813-820. 1982
1981 Distribution of anionic sites on surfaces of retinal cells: A study using cationized ferritinJournal of Structural Biology.  76:96-106. 1981
1981 Intercellular recognition: Quantitation of initial binding events 1981
1981 Ligatin from embryonic chick neural retina inhibits retinal cell adhesionDevelopmental Biology.  86:250-255. 1981
1979 Ligatin from embryonic chick neural retina 1979
1979 Separation of ectoderm and endoderm from sea urchin pluteus larvae and demonstration of germ layer-specific antigensDevelopmental Biology.  71:289-296. 1979
1978 Glycosyltransferase activities in developing chick embryos: potential roles in cell recognition and migrationBirth defects original article series.  14:317-326. 1978
1978 The potential roles for ganglioside GM2 and GM1 synthetase in retinotectal specificity.Symposia of the Society for Experimental Biology.  32:261-274. 1978
1978 Properties of a double gradient model for retinotectal specificityProgress in clinical and biological research.  VOL.23:637-645. 1978
1977 Biochemical investigations of retinotectal specificity.Progress in clinical and biological research.  15:73-79. 1977
1977 Biochemical investigations of retinotectal adhesive specificity 1977
1976 Intercellular adhesive specificity 1976
1975 A molecular approach to retinotectal specificity 1975
1975 A molecular approach to retinotectal specificity.Novartis Foundation symposium.  0:315-341. 1975
1973 Adhesive recognition and retinotectal specificity 1973

Chapter

Year Title Altmetric
2013 Phosphoglucomutase Is a Cytoplasmic Glycoprotein Implicated in the Regulated Secretory Pathway.  289-292. 2013
1984 Gene Expression and Cell-Cell Interactions in the Developing Nervous System 1984
1984 Receptor for Glycoproteins with Phosphorylated Oligosaccharides.  261-313. 1984

Education And Training

  • Doctor of Philosophy in Biophysics, Johns Hopkins University 1976
  • Awards And Honors

  • Charter Fellow, National Academy of Inventors, 2012
  • Fellow, American Association of Anatomists, 2010
  • A.J. Ladman Exemplary Service Award of the American Association of Anatomists, 2010
  • Mary Jane Kugle Award, Juvenile Diabetes Foundation International, 1999
  • National Science Foundation Presidential Young Investigator Award, 1989
  • National Science Foundation Presidential Young Investigator Award, 1988
  • National Science Foundation Presidential Young Investigator Award, 1987
  • National Science Foundation Presidential Young Investigator Award, 1986
  • Exxon Education Foundation Presidential Young Investigator Matching Funds, 1986
  • National Science Foundation Presidential Young Investigator Award, 1985
  • Exxon Education Foundation Presidential Young Investigator Matching Funds, 1985
  • National Science Foundation Presidential Young Investigator Award, 1984
  • Exxon Education Foundation Presidential Young Investigator Matching Funds, 1984
  • 1982-1985 Nanaline H. Duke Scholarship (Junior Faculty Research Award, Duke)
  • 1978 - Present Sigma Xi
  • 1977-1978 National Institutes of Health, Postdoctoral Fellowship
  • 1976-1977 Muscular Dystrophy Association, Postdoctoral Fellowship
  • 1975 Danforth Foundation Supplemental Grant for the Improvement of Undergraduate Education
  • 1972-1975 Danforth Foundation Graduate Fellowship
  • 1970-1972 National Science Foundation Graduate Fellowship
  • 1970 Cornell University Hamilton Watch Award (Outstanding Graduate in Science and Engineering)
  • 1970 First in class, Cornell University College of Engineering
  • 1969 Tau Beta Pi
  • Full Name

  • Richard Marchase